CYCLOTRAXIN B

Product Name: CYCLOTRAXIN B
CAS No.: 1203586-72-4
Chemical Name: CYCLOTRAXIN B
Synonyms: CYCLOTRAXIN B;Cyclotraxin-B trifluoroacetate salt;L-Cysteine, L-cysteinyl-L-asparaginyl-L-prolyl-L-methionylglycyl-L-tyrosyl-L-threonyl-L-lysyl-L-α-glutamylglycyl-, cyclic (1→11)-disulfide
CBNumber: CB64731894
Molecular Formula: C48H73N13O17S3
Formula Weight: 1200.37
MOL File: 1203586-72-4.mol

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CYCLOTRAXIN B Property

Boiling point:: 1734.8±65.0 °C(Predicted)
Density: 1.48±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: Sparingly soluble: 1-10 mg/mlPBS (pH 7.2): Soluble: = 10 mg/ml
form: Powder
pka: 2.95±0.70(Predicted)
color: White to off-white
Water Solubility: Soluble to 2 mg/ml in water
Sequence: Cys-Asn-Pro-Met-Gly-Tyr-Thr-Lys-Glu-Gly-Cys (Disulfide bridge:Cys1-Cys11)
InChIKey: JLBMMJHZUYBFGX-ZHTCEXBHSA-N

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1769
Product name: Cyclotraxin-B trifluoroacetate salt
Purity: ≥95% (HPLC)
Packaging: 1 mg
Price: $232
Updated: 2026/04/30

Cayman Chemical

Product number: 42991
Product name: Cyclotraxin B
Purity: ≥98%
Packaging: 1mg
Price: $197
Updated: 2026/04/30

Cayman Chemical

Product number: 42991
Product name: Cyclotraxin B
Purity: ≥98%
Packaging: 5mg
Price: $394
Updated: 2026/04/30

Cayman Chemical

Product number: 42991
Product name: Cyclotraxin B
Purity: ≥98%
Packaging: 10mg
Price: $690
Updated: 2026/04/30

Cayman Chemical

Product number: 42991
Product name: Cyclotraxin B
Purity: ≥98%
Packaging: 25mg
Price: $1478
Updated: 2026/04/30

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CYCLOTRAXIN B Chemical Properties,Usage,Production

Description

Antagonist of TrkB receptors; inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM). Allosterically alters TrkB receptor conformation but does not alter BDNF binding. Prevents BDNF-induced cold allodynia in mice. Also shown to exhibit putative anxiolytic properties in mice.

Uses

Cyclotraxin B is a BBB-penetrable and selective TrkB inhibitor. Cyclotraxin B inhibits BDNF-induced TrkB activity in a non-competitive manner, with an IC50 of 0.30 nM. Cyclotraxin B has analgesic and anxiolytic effects[1][2][3].

in vivo

Cyclotraxin B (intravenous injection; 2×200 μg; two times; with a 90-minute interval) has anxiolytic effects in mice^[1].
Cyclotraxin B (intraperitoneal injection; 2×20 mg/kg; two times; with a 90-minute interval) can prevent and reverse cold allodynia induced by BDNF or infraorbital nerve ligation in mice^[2].

Animal Model:	Adult Swiss mice (20-25 g)^[1]
Dosage:	2×200 μg (Cyclotraxin B was in the fusion form with the HIV tat protein)
Administration:	Intravenous injection; two times with a 90-minute interval
Result:	Dramatically decreased the total level of TrkB phosphorylation in the mouse brain. Does not possess any antidepressant-like properties when injected acutely. Significantly increased the time mice spent in the central area during the open field test. Significantly increased the number of entries and the time spent in open arms by mice during the elevated-plus maze.

IC 50

TrkB

storage

Store at -20°C

References

[1] Maxime Cazorla, et al. Cyclotraxin-B, the first highly potent and selective TrkB inhibitor, has anxiolytic properties in mice. PLoS One. 2010 Mar 19;5(3):e9777. DOI:10.1371/journal.pone.0009777
[2] Luis Constandil, et al. Cyclotraxin-B, a new TrkB antagonist, and glial blockade by propentofylline, equally prevent and reverse cold allodynia induced by BDNF or partial infraorbital nerve constriction in mice. J Pain. 2012 Jun;13(6):579-89. DOI:10.1016/j.jpain.2012.03.008
[3] Michel M M Verheij, et al. Systemic Delivery of a Brain-Penetrant TrkB Antagonist Reduces Cocaine Self-Administration and Normalizes TrkB Signaling in the Nucleus Accumbens and Prefrontal Cortex. J Neurosci. 2016 Aug 3;36(31):8149-59. DOI:10.1523/JNEUROSCI.2711-14.2016
[4] NATASHA M SOSANYA. Involvement of brain-derived neurotrophic factor (BDNF) in chronic intermittent stress-induced enhanced mechanical allodynia in a rat model of burn pain.[J]. BMC Neuroscience, 2019, 20 1: 17. DOI: 10.1186/s12868-019-0500-1

CYCLOTRAXIN B Preparation Products And Raw materials

Raw materials

Preparation Products

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CYCLOTRAXIN B Suppliers

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1203586-72-4, CYCLOTRAXIN BRelated Search:

CYCLOTRAXIN B

L-Cysteine, L-cysteinyl-L-asparaginyl-L-prolyl-L-methionylglycyl-L-tyrosyl-L-threonyl-L-lysyl-L-α-glutamylglycyl-, cyclic (1→11)-disulfide

Cyclotraxin-B trifluoroacetate salt

1203586-72-4

C48H73N13O17S3