TRAM 39
- Product Name
- TRAM 39
- CAS No.
- 197525-99-8
- Chemical Name
- TRAM 39
- Synonyms
- TRAM 39;2-Chloro-α,α-diphenylbenzeneacetonitrile;Benzeneacetonitrile, 2-chloro-α,α-diphenyl-;2-(2-chlorophenyl)-2,2-diphenylacetonitrile
- CBNumber
- CB64736703
- Molecular Formula
- C20H14ClN
- Formula Weight
- 303.79
- MOL File
- 197525-99-8.mol
TRAM 39 Property
- Boiling point:
- 425.0±40.0 °C(Predicted)
- Density
- 1.193±0.06 g/cm3(Predicted)
- storage temp.
- Store at RT
- solubility
- <15.44mg/ml in DMSO
- form
- solid
- color
- Yellow
N-Bromosuccinimide Price
- Product number
- 4952
- Product name
- TRAM39
- Purity
- ≥99%(HPLC)
- Packaging
- 5
- Price
- $82
- Updated
- 2021/12/16
- Product number
- 4952
- Product name
- TRAM39
- Purity
- ≥99%(HPLC)
- Packaging
- 25
- Price
- $346
- Updated
- 2021/12/16
- Product number
- T705103
- Product name
- TRAM39
- Packaging
- 50mg
- Price
- $375
- Updated
- 2021/12/16
- Product number
- 256954
- Product name
- TRAM 39
- Packaging
- 10mg
- Price
- $423
- Updated
- 2021/12/16
- Product number
- B7786
- Product name
- TRAM39
- Packaging
- 5mg
- Price
- $140
- Updated
- 2021/12/16
TRAM 39 Chemical Properties,Usage,Production
Uses
TRAM 39 is a TRAM 34 related compound, both of which have potent and selective inhibitory properties of the intermediate-conductance Ca2+-activated K+ channel, IKCa1. The pharmacological function of TRAM 34 and its related compounds deem them potential immunosuppressants.
Biological Activity
tram-39, 2-(2-chlorophenyl)-2, 2-diphenyl acetonitrile, is a potent, synthetic, selective inhibitor of intermediate-conductance ca2+-activated k+channels. tram-39 selectively block k-ca3 but do not inhibit other ca2+-activated k+channels.[1,3]intermediate conductance ca2-activated k channels are the product of the ikca1 genes and are important in regulating the membrane potential of colonic epithelial cells, and lymphocytes. the ikca1 gene is also important in volume regulation of red blood cells. ikca1 modulates the paneth cell alpha-defensin secretion and involve in the mucosal defense of the intestinal epithelium against ingested bacterial pathogens.[1,2]tram-39 inhibits the kca3,so as to inhibit paneth cell secretion stimulated by bacteria or bacterial lipopolysaccharide. endothelium-derived hyperpolarizing factor (edhf ) responses are brought about by the activation of endothelial skca and ikca.[1,3]a combination of tram-39 and apamin abolished endothelium-derived hyperpolarizing factor (edhf) mediated relaxation of the rat isolated mediated relaxation. the combination of tram-39 and apamin evoked a small, transient depolarization of endothelial cells.[2]
in vivo
TRAM-39 (1 μM; adds to the perfusate) fully blocks all IKCa channels in multicellular preparations[1].
storage
Store at RT
References
[1] ayabe t1, wulff h, darmoul d, etal. , modulation of mouse paneth cell alpha-defensin secretion by mikca1, a ca2+-activated, intermediate conductance potassium channel. j biol chem. 2002 feb 1;277(5):3793-800.
[2]hinton jm, langton pd. inhibition of edhf by two new combinations of k+-channel inhibitors in rat isolated mesenteric arteries. br j pharmacol. 2003 mar; 138(6):1031-5.
[3]burnham mp, johnson it, weston ah. impaired small-conductance ca2+-activated k+ channel-dependent edhf responses in type ii diabetic zdf rats. br j pharmacol. 2006 jun;148(4):434-41.