PZ-1

Product Name: PZ-1
CAS No.: 1800505-64-9
Chemical Name: PZ-1
Synonyms: PZ-1;Pz-1 >=98% (HPLC);Pz-1, 10 mM in DMSO;Pz 1,Vascular endothelial growth factor receptor,inhibit,RET,Pz-1,VEGFR,Inhibitor,Pz1;N-(5-(tert-Butyl)isoxazol-3-yl)-2-(4-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)phenyl)acetamide;Benzeneacetamide, N-[5-(1,1-dimethylethyl)-3-isoxazolyl]-4-[5-(1-methyl-1H-pyrazol-4-yl)-1H-benzimidazol-1-yl]-;N-(5-(tert-Butyl)isoxazol-3-yl)-2-(4-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)phenyl)acetamide , Pz-1
CBNumber: CB64741125
Molecular Formula: C26H26N6O2
Formula Weight: 454.52
MOL File: 1800505-64-9.mol

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PZ-1 Property

Density: 1.28±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in DMSO
form: powder
pka: 12?+-.0.70(Predicted)
color: white to beige

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1693
Product name: Pz-1
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $108
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1693
Product name: Pz-1
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $386
Updated: 2022/05/15

ChemScene

Product number: CS-0035381
Product name: Pz-1
Purity: >99.0%
Packaging: 10mg
Price: $390
Updated: 2021/12/16

ChemScene

Product number: CS-0035381
Product name: Pz-1
Purity: >99.0%
Packaging: 25mg
Price: $790
Updated: 2021/12/16

ChemScene

Product number: CS-0035381
Product name: Pz-1
Purity: >99.0%
Packaging: 5mg
Price: $220
Updated: 2021/12/16

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PZ-1 Chemical Properties,Usage,Production

Biological Activity

Pz-1 is a cell-permeable, non-cytotoxic (up to 0.1 μM and 6 days; NIH/3T3 cells), and highly potent type II kinase inhibitor th at potently inhibits RET and VEGFR2 tyrosine kinase activity (IC50 <1 nM; [ATP] = 190 μM) by targeting the kinases in their inactive DFG-out conformation, displaying significant affinity (Kd <50 nM) toward only TRKB, TRKC, GKA, FYN, SRC, TAK1, MUSK from a panel of 96 other kinases. Pz-1 inhibits cellular RET mutants (C634R, C634Y, V804L, V804M, M918T) and VEGFR2 phosphorylations, and selectively inhibits the growth of RET C634Y- than HRas G12V-transformed NIH/3T3 cultures (IC50 = 0.5 vs. 34.4 nM). Likewise, Pz-1 completely abrogated tumor formation from RET C634Y-transformed NIH/3T3 cells in mice in vivo (1 mg/kg/d, p.o.), while only up to 70% tumor suppression of HRas G12V-transformed cells was achieved with 10 mg/kg daily oral dosage.

PZ-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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PZ-1 Suppliers

CHINA 15 Japan 1 United States 3 Global 19

Zhengzhou HSH Science & Technology Co., Ltd.

Tel: 0371-55932928 18937192232
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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Energy Chemical

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Zhengzhou convergence chemical co., LTD

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Shanghai Yifei Biotechnology Co. , Ltd.

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Nanjing Shizhou Biology Technology Co.,Ltd

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RD International Technology Co., Limited

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Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd.

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Absin Bioscience Inc.

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Proteintech China

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1800505-64-9, PZ-1Related Search:

PZ-1

Benzeneacetamide, N-[5-(1,1-dimethylethyl)-3-isoxazolyl]-4-[5-(1-methyl-1H-pyrazol-4-yl)-1H-benzimidazol-1-yl]-

Pz-1 >=98% (HPLC)

Pz 1,Vascular endothelial growth factor receptor,inhibit,RET,Pz-1,VEGFR,Inhibitor,Pz1

N-(5-(tert-Butyl)isoxazol-3-yl)-2-(4-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)phenyl)acetamide , Pz-1

N-(5-(tert-Butyl)isoxazol-3-yl)-2-(4-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)phenyl)acetamide

Pz-1, 10 mM in DMSO

1800505-64-9