ChemicalBook > CAS DataBase List > MA-0204

MA-0204

Product Name: MA-0204
CAS No.: 2095128-17-7
Chemical Name: MA-0204
Synonyms: CS-2841;MA-0204;MA-0204, 10 mM in DMSO;MA0204,inhibit,MA 0204,Peroxisome proliferator-activated receptors,MA-0204,PPAR,Inhibitor;(R)-3-methyl-6-(2-((5-methyl-2-(4-(trifluoromethoxy)phenyl)-1H-imidazol-1-yl)methyl)phenoxy)hexanoic acid;(3R)-3-methyl-6-[2-({5-methyl-2-[4-(trifluoromethoxy)phenyl]-1H-imidazol-1-yl}methyl)phenoxy]hexanoic acid;Hexanoic acid, 3-methyl-6-[2-[[5-methyl-2-[4-(trifluoromethoxy)phenyl]-1H-imidazol-1-yl]methyl]phenoxy]-, (3R)-
CBNumber: CB64744843
Molecular Formula: C25H27F3N2O4
Formula Weight: 476.49
MOL File: 2095128-17-7.mol

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MA-0204 Property

Boiling point:: 611.9±65.0 °C(Predicted)
Density: 1.23±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Solid
pka: 4.76±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biorbyt Ltd

Product number: orb573177
Product name: MA-0204
Purity: >98%
Packaging: 100mg
Price: $1431.4
Updated: 2021/12/16

ChemScene

Product number: CS-0064227
Product name: MA-0204
Purity: 99.71%
Packaging: 25mg
Price: $1500
Updated: 2021/12/16

ChemScene

Product number: CS-0064227
Product name: MA-0204
Purity: 99.71%
Packaging: 50mg
Price: $2100
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573177
Product name: MA-0204
Purity: >98%
Packaging: 250mg
Price: $2395.3
Updated: 2021/12/16

ChemScene

Product number: CS-0064227
Product name: MA-0204
Purity: 99.71%
Packaging: 100mg
Price: $3100
Updated: 2021/12/16

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MA-0204 Chemical Properties,Usage,Production

Uses

MA-0204 is a potent, highly selective and orally available peroxisome proliferator activated receptor δ (PPARδ) modulator with EC50s of 0.4 nM, 7.9 nM and 10 nM for human, mouse and rat PPARδ, respectively. Potential treatment for Duchene Muscular Dystrophy (DMD)[1].

in vivo

PPARδ (30, 100 mg/kg) increases target gene transcription in the muscle^[1].

IC 50

PPARδ: 0.4 nM (EC₅₀, in human); PPARδ: 7.9 nM (EC₅₀, in mouse); PPARδ: 10 nM (EC₅₀, in rat)

References

[1] Lagu B, et al. Selective PPARδ Modulators Improve Mitochondrial Function: Potential Treatment for Duchenne Muscular Dystrophy (DMD). ACS Med Chem Lett. 2018 Jul 31;9(9):935-940. DOI:10.1021/acsmedchemlett.8b00287

MA-0204 Preparation Products And Raw materials

Raw materials

Preparation Products

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MA-0204 Suppliers

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2095128-17-7, MA-0204Related Search:

MA-0204

CS-2841

Hexanoic acid, 3-methyl-6-[2-[[5-methyl-2-[4-(trifluoromethoxy)phenyl]-1H-imidazol-1-yl]methyl]phenoxy]-, (3R)-

MA0204,inhibit,MA 0204,Peroxisome proliferator-activated receptors,MA-0204,PPAR,Inhibitor

(R)-3-methyl-6-(2-((5-methyl-2-(4-(trifluoromethoxy)phenyl)-1H-imidazol-1-yl)methyl)phenoxy)hexanoic acid

(3R)-3-methyl-6-[2-({5-methyl-2-[4-(trifluoromethoxy)phenyl]-1H-imidazol-1-yl}methyl)phenoxy]hexanoic acid

MA-0204, 10 mM in DMSO

2095128-17-7