ORY-1001(trans)

Product Name: ORY-1001(trans)
CAS No.: 1431303-72-8
Chemical Name: ORY-1001(trans)
Synonyms: Ladademstat;ORY-1001(trans);ORY1001 HCl salt;ORY-1001(Ladademstat);ORY-1001 dihydrochloride;Iadademstat dihydrochloride;Iadademstat dihydrochloride, 10 mM in DMSO;(1r,4R)-N1-((1R,2S)-2-phenylcyclopropyl)cyclohexane-1,4-diamine;trans-N1-((1R,2S)-2-Phenylcyclopropyl)cyclohexane-1,4-diamine dihydrochloride;RO 7051790,RG 6016,Iadademstat dihydrochloride,Histone Demethylase,Iadademstat,RO7051790,inhibit,RG6016,Inhibitor,ORY1001,RO-7051790,ORY 1001,ORY-1001,RG-6016
CBNumber: CB64796675
Molecular Formula: C15H23ClN2
Formula Weight: 266.81
MOL File: 1431303-72-8.mol

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ORY-1001(trans) Property

storage temp.: Store at -20°C
solubility: Water: 57.75 mg/mL (190.42 mM and warming); DMSO: 0.69 mg/mL (2.28 mM and warming)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0044434
Product name: ORY-1001(trans)
Purity: 98.30%
Packaging: 5mg
Price: $110
Updated: 2021/12/16

ChemScene

Product number: CS-0044434
Product name: ORY-1001(trans)
Purity: 98.30%
Packaging: 10mg
Price: $180
Updated: 2021/12/16

ChemScene

Product number: CS-0044434
Product name: ORY-1001(trans)
Purity: 98.30%
Packaging: 50mg
Price: $700
Updated: 2021/12/16

ChemScene

Product number: CS-0044434
Product name: ORY-1001(trans)
Purity: 98.30%
Packaging: 100mg
Price: $1200
Updated: 2021/12/16

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ORY-1001(trans) Chemical Properties,Usage,Production

Uses

Iadademstat (ORY-1001) dihydrochloride is a selective irreversible lysine (K)-specific demethylase 1A (KDM1A/LSD1) inhibitor.

in vivo

Iadademstat reduces AML tumor growth in mice and rat xenografts and increases survival time in a disseminated model of T-ALL^[1].

References

[1] Maes T, et al. KDM1 histone lysine demethylases as targets for treatments of oncological and neurodegenerative disease. Epigenomics. 2015;7(4):609-26. doi: 10.2217/epi.15.9. DOI:10.2217/epi.15.9
[2] Tamara Maes, et al. ORY-1001, a Potent and Selective Covalent KDM1A Inhibitor, for the Treatment of Acute Leukemia. Cancer Cell. 2018 Mar 12;33(3):495-511.e12. DOI:10.1016/j.ccell.2018.02.002

ORY-1001(trans) Preparation Products And Raw materials

Raw materials

Preparation Products

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ORY-1001(trans) Suppliers

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1431303-72-8, ORY-1001(trans)Related Search:

ORY-1001(trans)

trans-N1-((1R,2S)-2-Phenylcyclopropyl)cyclohexane-1,4-diamine dihydrochloride

Ladademstat

ORY-1001 dihydrochloride

Iadademstat dihydrochloride

RO 7051790,RG 6016,Iadademstat dihydrochloride,Histone Demethylase,Iadademstat,RO7051790,inhibit,RG6016,Inhibitor,ORY1001,RO-7051790,ORY 1001,ORY-1001,RG-6016

(1r,4R)-N1-((1R,2S)-2-phenylcyclopropyl)cyclohexane-1,4-diamine

ORY-1001(Ladademstat)

ORY1001 HCl salt

Iadademstat dihydrochloride, 10 mM in DMSO

1431303-72-8