GCN2iB

Product Name: GCN2iB
CAS No.: 2183470-12-2
Chemical Name: GCN2iB
Synonyms: GCN2iB;GCN2iB HCl salt;GCN2iB, 10 mM in DMSO;inhibit,GCN-2iB,Inhibitor,GCN2iB,Eukaryotic Initiation Factor (eIF),Autophagy;N-(3-((2-Aminopyrimidin-5-yl)ethynyl)-2,4-difluorophenyl)-5-chloro-2-methoxypyridine-3-sulfonamide;N-[3-[2-(2-Amino-5-pyrimidinyl)ethynyl]-2,4-difluorophenyl]-5-chloro-2-methoxy-3-pyridinesulfonamide;3-Pyridinesulfonamide, N-[3-[2-(2-amino-5-pyrimidinyl)ethynyl]-2,4-difluorophenyl]-5-chloro-2-methoxy-;N-(3-((2-Aminopyrimidin-5-yl)ethynyl)-2,4-difluorophenyl)-5-chloro-2-methoxypyridine-3-sulfonamide , GCN2iB
CBNumber: CB64797061
Molecular Formula: C18H12ClF2N5O3S
Formula Weight: 451.83
MOL File: 2183470-12-2.mol

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GCN2iB Property

Boiling point:: 662.6±65.0 °C(Predicted)
Density: 1.63±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 16.67 mg/mL (36.89 mM);Water : < 0.1 mg/mL (insoluble)
pka: 4.80±0.50(Predicted)
form: Solid
color: Off-white to light yellow
InChI: InChI=1S/C18H12ClF2N5O3S/c1-29-17-15(6-11(19)9-23-17)30(27,28)26-14-5-4-13(20)12(16(14)21)3-2-10-7-24-18(22)25-8-10/h4-9,26H,1H3,(H2,22,24,25)
InChIKey: JGHVXJKGYJYWOP-UHFFFAOYSA-N
SMILES: C1(OC)=NC=C(Cl)C=C1S(NC1=CC=C(F)C(C#CC2=CN=C(N)N=C2)=C1F)(=O)=O

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: A629106
Product name: N-[3-[2-(2-Amino-5-pyrimidinyl)ethynyl]-2,4-difluorophenyl]-5-chloro-2-methoxy-3-pyridinesulfonamide
Packaging: 25mg
Price: $1540
Updated: 2021/12/16

ChemScene

Product number: CS-0058993
Product name: GCN2iB
Purity: 99.81%
Packaging: 100mg
Price: $2100
Updated: 2021/12/16

ChemScene

Product number: CS-0058993
Product name: GCN2iB
Purity: 99.81%
Packaging: 5mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0058993
Product name: GCN2iB
Purity: 99.81%
Packaging: 10mg
Price: $450
Updated: 2021/12/16

ChemScene

Product number: CS-0058993
Product name: GCN2iB
Purity: 99.81%
Packaging: 25mg
Price: $900
Updated: 2021/12/16

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GCN2iB Chemical Properties,Usage,Production

Uses

N-[3-[2-(2-Amino-5-pyrimidinyl)ethynyl]-2,4-difluorophenyl]-5-chloro-2-methoxy-3-pyridinesulfonamide is an intermediate used in the preparation of heterocyclic compounds as GCN2 inhibitors.

in vivo

In the antitumor activity study of the CCRF-CEM xenografts, ASNase or GCN2iB alone does not significantly affect tumor growth. Notably, a combination of ASNase and GCN2iB elicit potent antitumor activity (P=0.0002) with synergistic effects. In MV-4-11 and SU.86.86 xenografts, robust antitumor activity of the combination of GCN2iB and ASNase is observed with synergistic effect, respectively. ASNase/GCN2iB-treated tumors do not show significant growth even after drug cessation. The combination of ASNase and GCN2iB yield survival advantage compared with the vehicle treated control with synergistic effect^[1].

IC 50

eIF2

GCN2iB Preparation Products And Raw materials

Raw materials

Preparation Products

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GCN2iB Suppliers

China 44 United States 4 Global 48

WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

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2183470-12-2, GCN2iBRelated Search:

GCN2iB

GCN2iB HCl salt

N-[3-[2-(2-Amino-5-pyrimidinyl)ethynyl]-2,4-difluorophenyl]-5-chloro-2-methoxy-3-pyridinesulfonamide

3-Pyridinesulfonamide, N-[3-[2-(2-amino-5-pyrimidinyl)ethynyl]-2,4-difluorophenyl]-5-chloro-2-methoxy-

inhibit,GCN-2iB,Inhibitor,GCN2iB,Eukaryotic Initiation Factor (eIF),Autophagy

N-(3-((2-Aminopyrimidin-5-yl)ethynyl)-2,4-difluorophenyl)-5-chloro-2-methoxypyridine-3-sulfonamide

N-(3-((2-Aminopyrimidin-5-yl)ethynyl)-2,4-difluorophenyl)-5-chloro-2-methoxypyridine-3-sulfonamide , GCN2iB

GCN2iB, 10 mM in DMSO

2183470-12-2

C18H12ClF2N5O3S