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Z-PRO-PRO-ALDEHYDE-DIMETHYL ACETAL

Product Name
Z-PRO-PRO-ALDEHYDE-DIMETHYL ACETAL
CAS No.
170116-63-9
Chemical Name
Z-PRO-PRO-ALDEHYDE-DIMETHYL ACETAL
Synonyms
Z-PRO-PRO-ALDEHYDE-DIMETHYL ACETAL;1-Pyrrolidinecarboxylic acid, 2-[[(2S)-2-(dimethoxymethyl)-1-pyrrolidinyl]carbonyl]-, phenylmethyl ester, (2S)-
CBNumber
CB6480325
Molecular Formula
C20H28N2O5
Formula Weight
376.45
MOL File
Mol file
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Z-PRO-PRO-ALDEHYDE-DIMETHYL ACETAL Property

Boiling point:
522.5±50.0 °C(Predicted)
Density 
1.214±0.06 g/cm3(Predicted)
storage temp. 
-15°C
pka
-1.00±0.40(Predicted)
Sequence
Pro-{Pro-Aldehyde-dimethyl acetal}
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
PEP0004938
Product name
Z-PRO-PRO-ALDEHYDE-DIMETHYL ACETAL
Purity
95.00%
Packaging
5MG
Price
$502.34
Updated
2021/12/16
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Z-PRO-PRO-ALDEHYDE-DIMETHYL ACETAL Chemical Properties,Usage,Production

Uses

Z-Pro-Pro-aldehyde-dimethyl acetal is a potent inhibitor of prolyl endopeptidase (PREP), a cytoplasmic serine endoprotease (IC50= 12 nM). Z-Pro-Pro-aldehyde-dimethyl acetal plays an important role in cognitive dysfunction in aging and neurodegenerative diseases including Alzheimer's disease[1][2].

IC 50

PREP: 12 nM (IC50)

References

[1] Robin S B Williams, et al. A common mechanism of action for three mood-stabilizing drugs. Nature. 2002 May 16;417(6886):292-5. DOI:10.1038/417292a
[2] Andis Klegeris, et al. Prolyl endopeptidase is revealed following SILAC analysis to be a novel mediator of human microglial?and?THP‐1 cell neurotoxicity. Glia. 2008 Apr 15;56(6):675-85. DOI:10.1002/glia.20645

Z-PRO-PRO-ALDEHYDE-DIMETHYL ACETAL Preparation Products And Raw materials

Raw materials

Preparation Products

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Z-PRO-PRO-ALDEHYDE-DIMETHYL ACETAL Suppliers

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GL Biochem (Shanghai) Ltd
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170116-63-9, Z-PRO-PRO-ALDEHYDE-DIMETHYL ACETALRelated Search:

Z-D-GLA(OTBU)2-OH

  • Z-PRO-PRO-ALDEHYDE-DIMETHYL ACETAL
  • 1-Pyrrolidinecarboxylic acid, 2-[[(2S)-2-(dimethoxymethyl)-1-pyrrolidinyl]carbonyl]-, phenylmethyl ester, (2S)-
  • 170116-63-9