ChemicalBook > CAS DataBase List > Z-PRO-PRO-ALDEHYDE-DIMETHYL ACETAL
Z-PRO-PRO-ALDEHYDE-DIMETHYL ACETAL
- Product Name
- Z-PRO-PRO-ALDEHYDE-DIMETHYL ACETAL
- CAS No.
- 170116-63-9
- Chemical Name
- Z-PRO-PRO-ALDEHYDE-DIMETHYL ACETAL
- Synonyms
- Z-PRO-PRO-ALDEHYDE-DIMETHYL ACETAL;1-Pyrrolidinecarboxylic acid, 2-[[(2S)-2-(dimethoxymethyl)-1-pyrrolidinyl]carbonyl]-, phenylmethyl ester, (2S)-
- CBNumber
- CB6480325
- Molecular Formula
- C20H28N2O5
- Formula Weight
- 376.45
- MOL File
- Mol file
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Z-PRO-PRO-ALDEHYDE-DIMETHYL ACETAL Property
- Boiling point:
- 522.5±50.0 °C(Predicted)
- Density
- 1.214±0.06 g/cm3(Predicted)
- storage temp.
- -15°C
- pka
- -1.00±0.40(Predicted)
- Sequence
- Pro-{Pro-Aldehyde-dimethyl acetal}
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N-Bromosuccinimide Price
American Custom Chemicals Corporation
- Product number
- PEP0004938
- Product name
- Z-PRO-PRO-ALDEHYDE-DIMETHYL ACETAL
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.34
- Updated
- 2021/12/16
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Z-PRO-PRO-ALDEHYDE-DIMETHYL ACETAL Chemical Properties,Usage,Production
Uses
Z-Pro-Pro-aldehyde-dimethyl acetal is a potent inhibitor of prolyl endopeptidase (PREP), a cytoplasmic serine endoprotease (IC50= 12 nM). Z-Pro-Pro-aldehyde-dimethyl acetal plays an important role in cognitive dysfunction in aging and neurodegenerative diseases including Alzheimer's disease[1][2].
IC 50
PREP: 12 nM (IC50)
References
[1] Robin S B Williams, et al. A common mechanism of action for three mood-stabilizing drugs. Nature. 2002 May 16;417(6886):292-5. DOI:10.1038/417292a
[2] Andis Klegeris, et al. Prolyl endopeptidase is revealed following SILAC analysis to be a novel mediator of human microglial?and?THP‐1 cell neurotoxicity. Glia. 2008 Apr 15;56(6):675-85. DOI:10.1002/glia.20645
Z-PRO-PRO-ALDEHYDE-DIMETHYL ACETAL Preparation Products And Raw materials
Raw materials
Preparation Products
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Z-PRO-PRO-ALDEHYDE-DIMETHYL ACETAL Suppliers
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- 1-631-485-4226; 16314854226
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