6-FLUORO-4-HYDROXYCOUMARIN

Product Name: 6-FLUORO-4-HYDROXYCOUMARIN
CAS No.: 1994-13-4
Chemical Name: 6-FLUORO-4-HYDROXYCOUMARIN
Synonyms: 6-Fluro-4-hydroxycoumarin;6-FLUORO-4-HYDROXYCOUMARIN;6-Fluoro-4-hydroxycoumarine;6- Fluoro- 4- hydroxy coumarain;6-FLUORO-4-HYDROXY-2H-CHROMEN-2-ONE;6-Fluoro-4-hydroxy-2H-1-Benzopyran-2-one;2H-1-Benzopyran-2-one, 6-fluoro-4-hydroxy-;JRH-01309, 6-Fluoro-4-hydroxy-2H-chromen-2-one, 97%
CBNumber: CB6481281
Molecular Formula: C9H5FO3
Formula Weight: 180.13
MOL File: 1994-13-4.mol

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6-FLUORO-4-HYDROXYCOUMARIN Property

Melting point:: 248-251 °C(lit.)
Boiling point:: 354.0±42.0 °C(Predicted)
Density: 1.549±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
pka: 4.50±1.00(Predicted)
color: White to Light yellow

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Safety

Hazard Codes: Xi
WGK Germany: 3
Hazard Note: Irritant
HS Code: 2932209090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: F0906
Product name: 6-Fluoro-4-hydroxycoumarin
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $38
Updated: 2025/07/31

TRC

Product number: B434805
Product name: 6-fluoro-4-hydroxychromen-2-one
Packaging: 100mg
Price: $55
Updated: 2021/12/16

TRC

Product number: B434805
Product name: 6-fluoro-4-hydroxychromen-2-one
Packaging: 250mg
Price: $110
Updated: 2021/12/16

TRC

Product number: B434805
Product name: 6-fluoro-4-hydroxychromen-2-one
Packaging: 500mg
Price: $170
Updated: 2021/12/16

Apolloscientific

Product number: PC6507
Product name: 6-Fluoro-4-hydroxycoumarin
Packaging: 1g
Price: $105
Updated: 2021/12/16

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6-FLUORO-4-HYDROXYCOUMARIN Chemical Properties,Usage,Production

Synthesis

394-32-1

105-58-8

1994-13-4

5-Fluoro-2-hydroxyacetophenone (1.54 g, 10 mmol) and diethyl carbonate (2.42 mL, 20 mmol) were dissolved in anhydrous tetrahydrofuran (30 mL) in a dry flask. The above solution was added dropwise to a rapidly stirred solution of potassium tert-butanolate tetrahydrofuran (1.0 M, 30 mL) through a cannula. The reaction was stirred overnight (10 hours) at room temperature and under positive pressure protection with nitrogen. Upon completion of the reaction, the crude product was concentrated under reduced pressure and partitioned between methyl tert-butyl ether and water. The layers were separated and the organic phase was discarded. The aqueous phase was adjusted to pH 5 with hydrochloric acid and subsequently extracted three times with an equal volume of dichloromethane. The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford 6-fluoro-4-hydroxy-2H-benzopyran-2-one (1.4 g, 78% yield). Mass spectrum (ESI negative ion mode) m/e: 179.16 ([M-H]-).

References

[1] Journal of Medicinal Chemistry, 2009, vol. 52, # 22, p. 7142 - 7156
[2] Patent: WO2009/100250, 2009, A1. Location in patent: Page/Page column 57
[3] Organic and Biomolecular Chemistry, 2018, vol. 16, # 15, p. 2634 - 2638
[4] Patent: EP354693, 1990, A1
[5] Advanced Synthesis and Catalysis, 2013, vol. 355, # 13, p. 2550 - 2557

6-FLUORO-4-HYDROXYCOUMARIN Preparation Products And Raw materials

Raw materials

Preparation Products

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6-FLUORO-4-HYDROXYCOUMARIN Suppliers

Americas 1 China 65 Europe 1 Germany 2 India 19 Japan 1 Switzerland 1 United Kingdom 6 United States 13 Global 109

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View Lastest Price from 6-FLUORO-4-HYDROXYCOUMARIN manufacturers

Career Henan Chemical Co

Product: 6-FLUORO-4-HYDROXYCOUMARIN 1994-13-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98% HPLC
Supply Ability: 10 tons/month
Release date: 2020-01-09

1994-13-4, 6-FLUORO-4-HYDROXYCOUMARINRelated Search:

Hydrogen fluoride Menadione Coryfolin 5,5-Dimethylhydantoin Meldrum's Acid Coumarin 6 5-Fluoro-2-Methoxybenzyl alcohol 6-FLUORO-4-HYDROXYCOUMARIN 4-ETHOXY-6-FLUOROCOUMARIN 6-FLUORO-4-HYDROXY-3-NITROCOUMARIN 6-FLUORO-4-HYDROXY-2-OXO-2H-CHROMENE-3-CARBALDEHYDE

JRH-01309, 6-Fluoro-4-hydroxy-2H-chromen-2-one, 97%

6-Fluoro-4-hydroxy-2H-1-Benzopyran-2-one

6-FLUORO-4-HYDROXY-2H-CHROMEN-2-ONE

6-FLUORO-4-HYDROXYCOUMARIN

2H-1-Benzopyran-2-one, 6-fluoro-4-hydroxy-

6-Fluoro-4-hydroxycoumarine

6- Fluoro- 4- hydroxy coumarain

6-Fluro-4-hydroxycoumarin

1994-13-4

C9H5FO3

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Coumarins

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API intermediates