3,4,5-Trifluorophenylboronic acid

ChemicalBook > CAS DataBase List > 3,4,5-Trifluorophenylboronic acid

3,4,5-Trifluorophenylboronic acid

Uses

Product Name: 3,4,5-Trifluorophenylboronic acid
CAS No.: 143418-49-9
Chemical Name: 3,4,5-Trifluorophenylboronic acid
Synonyms: AKOS BRN-0138;3,4,5-Trifluoropheny;3,4,5-trifluoroborate;5-Trifluorophenylboronic acid;3,4,5-three fluorophenyl borate;3,4,5-Trifluophenylboronic acid;3,4,5-TRIFLUOROPHENYLBORONIC ACID;3,4,5-TRIFLUOROBENZENEBORONIC ACID;3,4,5-Trifluorophenylboronic Aicd;3,4,5-Trifluorobenzeneboronicacid97%
CBNumber: CB6481302
Molecular Formula: C6H4BF3O2
Formula Weight: 175.9
MOL File: 143418-49-9.mol

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3,4,5-Trifluorophenylboronic acid Property

Melting point:: 290-295 °C (lit.)
Boiling point:: 263.6±50.0 °C(Predicted)
Density: 1,087g/cm
refractive index: 1,423-1,425
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: 18.43g/l
form: Powder
pka: 6.54±0.11(Predicted)
color: Tan
BRN: 7371914
InChIKey: UHDDEIOYXFXNNJ-UHFFFAOYSA-N
CAS DataBase Reference: 143418-49-9(CAS DataBase Reference)

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Safety

Hazard Codes: N-Xn,Xi
Risk Statements: 51/53-36-22-36/37/38
Safety Statements: 61-26-37/39-36
RIDADR: 3077
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29163990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 524700
Product name: 3,4,5-Trifluorophenylboronic acid
Purity: ≥95%
Packaging: 1g
Price: $29.1
Updated: 2023/06/20

Sigma-Aldrich

Product number: 524700
Product name: 3,4,5-Trifluorophenylboronic acid
Purity: ≥95%
Packaging: 5g
Price: $134
Updated: 2023/06/20

Alfa Aesar

Product number: L18519
Product name: 3,4,5-Trifluorobenzeneboronic acid, 97%
Packaging: 250mg
Price: $56
Updated: 2023/06/20

Alfa Aesar

Product number: L18519
Product name: 3,4,5-Trifluorobenzeneboronic acid, 97%
Packaging: 1g
Price: $181
Updated: 2023/06/20

ChemScene

Product number: CS-D1006
Product name: 3,4,5-Trifluorophenylboronic acid
Purity: 99.51%
Packaging: 500g
Price: $333
Updated: 2021/12/16

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3,4,5-Trifluorophenylboronic acid Chemical Properties,Usage,Production

Uses

Reactant involved in:
• Preparation of phenylboronic catechol esters and determination of Lewis acidity
• Synthesis of benzopyranone derivatives as GABAA receptor modulators
• Synthesis of multisubstituted olefins and conjugate dienes
• Suzuki cross-coupling reactions
• Preparation of fluorinated aromatic poly(ether-amide)s

Description

3,4,5-Trifluorophenylboronic acid is an arylboronic acid compound used in organic synthesis and as a reaction reagent. It can be used as a catalyst to catalyse the direct amidation of amino acid derivatives and the direct polycondensation of carboxylic acids and amines; it can also be used in the formation of new 1:1 co-crystals with urea C6H4BF3O2-CH4N2O components.

Chemical Properties

Tan powder

Uses

suzuki reaction

Uses

Reactant involved in:

Preparation of phenylboronic catechol esters and determination of Lewis acidity
Synthesis of benzopyranone derivatives as GABAA receptor modulators
Synthesis of multisubstituted olefins and conjugate dienes
Suzuki cross-coupling reactions
Preparation of fluorinated aromatic poly(ether-amide)s

Uses

Intermediates of Liquid Crystals

Synthesis

Add 42mmol (10.08g) of magnesium chips into a 1000mL four-necked flask, add 2 pieces of iodine, and then add 200mL of anhydrous 2-methyltetrahydrofuran, heat the temperature to 50°C, and then slowly let it cool down to 40°C. And then drip 4-5mL of 3,4,5-trifluorobromobenzene 84.4g (0.4mol) and 50mL 2-methyltetrahydrofuran mixed solution, trigger the Grignard reaction, the temperature will rise rapidly after the reaction is initiated, use The temperature is lowered to 10-15°C in an ice-water bath, and a mixture (1) composed of 3,4,5-trifluorobromobenzene 84.4g (0.4mol) and 50mL 2-methyltetrahydrofuran (1), trimethyl borate is added dropwise. A mixture of 44 grams (0.42 mol) of ester and 50 mL of 2-methyltetrahydrofuran (2).The speed of the mixed solution (1) and the mixed solution (2) is kept the same, the dropping speed is controlled, and the dropping temperature is kept at 10-15°C . After the dropping is completed, the reaction is continued at room temperature for 8 hours.After the reaction is over, the reaction solution is slowly poured into dilute hydrochloric acid, and after the addition is complete, stir for 0.5-1.5h, separate the liquids, and then extract the aqueous phase twice, combine the organic phases, dry with anhydrous sodium sulfate, spin dry, and Recrystallization of ethyl chloride gave 3,4,5-Trifluorophenylboronic acid with a yield of 78% and a content of 99.6%.

3,4,5-Trifluorophenylboronic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3,4,5-Trifluorophenylboronic acid manufacturers

Henan Fengda Chemical Co., Ltd

Product: 3,4,5-Trifluorophenylboronic acid 143418-49-9
Price: US $8.00-0.80/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-01-22

Shaanxi Dideu Medichem Co. Ltd

Product: 3,4,5-Trifluorophenylboronic acid 143418-49-9
Price: US $10.00-1000.00/g
Min. Order: 5mg
Purity: 99.0% HPLC
Supply Ability: 2000tons
Release date: 2021-03-09

Hebei Yanxi Chemical Co., Ltd.

Product: 3,4,5-Trifluorophenylboronic acid 143418-49-9
Price: US $10.00-5.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-10-10

143418-49-9, 3,4,5-Trifluorophenylboronic acidRelated Search:

Trimethyl borate 2,3,4,5,6-PENTAFLUOROBENZENEBORONIC ACID Triisopropyl borate Phenylboronic acid 4-Fluorobenzeneboronic acid Tributyl borate 3,5-Difluorophenylboronic acid 2,3,4,5-TETRAFLUOROBENZENEBORONIC ACID 2,3,6-Trifluorophenylboronic acid 2,3,4-Trifluorophenylboronic Acid (contains varying amounts of Anhydride),4-TRIFLUOROPHENYLBORONIC ACID,2,3,4-TRIFLUOROPHENYLBORONIC ACID 2,3,6-TRIFLUOROPHENYLBORONIC ACID 2,4,6-TRIFLUOROPHENYLBORONIC ACID 5-Bromo-2,3,4-Trifluorophenylboronic acid 2,4,5-TRIFLUOROPHENYLBORONIC ACID 6-Bromo-2,3,4-Trifluorophenylboronic acid 2,4,5-TRIFLUOROPHENYLBORONIC ACID,2,3,5-TRIFLUOROPHENYLBORONIC ACID 2,4,5-Trifluorophenylboronic acid Boric acid

AKOS BRN-0138

3,4,5-TRIFLUOROPHENYLBORONIC ACID

3,4,5-TRIFLUOROBENZENEBORONIC ACID

3,4,5-Trifluophenylboronic acid

3,4,5-Trifluorobenzeneboronic acid 97%

3,4,5-Trifluorobenzeneboronicacid97%

3,4,5-TRIFLUOROPHENYLBORONIC ACID MIN 96% HPLC

3,4,5-Trifluorophenylboronic Aicd

Boronic acid, B-(3,4,5-trifluorophenyl)-

3,4,5-Trifluorophenylboronic acid ,97%

3,4,5-TRIFLUOROPHENYLBORONIC ACID, 95+%

3,4,5-Trifluoropheny

3,4,5-three fluorophenyl borate

5-Trifluorophenylboronic acid

3,4,5-Trifluorophenylboronic acid (contains varying aMounts of Anhydride)

dihydroxy(3,4,5-trifluorophenyl)borane

3,4,5-TRIFLUOROPHENYLBORONIC ACID FOR SY

3,4,5-TRIFLUOROPHENYL BORONIC ACID;BORONIC ACID, B-(3,4,5-TRIFLUOROPHENYL)-;

3,4,5-trifluoroborate

143418-49-9

143418-49-8

443418-49-9

418-49-9

Boronic Acids and Derivatives

Boronic Acids

Aryl

Organometallic Reagents

BORONIC ACID

Piperidines

Boronic Acids

Boronic Acids and Derivatives

Aryl

Fluorinated

Organoborons

Substituted Boronic Acids

Fluorin-contained phenyl boronic acid series

Boronic Acid

blocks

BoronicAcids

Boronic Acid series

Fluoro-Aromatics