ChemicalBook > CAS DataBase List > 5-((5-(2-(3-aminopropoxy)-4-fluoro-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile

5-((5-(2-(3-aminopropoxy)-4-fluoro-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile

Product Name
5-((5-(2-(3-aminopropoxy)-4-fluoro-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile
CAS No.
2120398-39-0
Chemical Name
5-((5-(2-(3-aminopropoxy)-4-fluoro-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile
Synonyms
Chk1-IN-5;Chk-1-IN-5,Chk1IN5,Chk1 IN 5;5-((5-(2-(3-aminopropoxy)-4-fluoro-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile;2-Pyrazinecarbonitrile, 5-[[5-[2-(3-aminopropoxy)-4-fluoro-6-methoxyphenyl]-1H-pyrazol-3-yl]amino]-
CBNumber
CB64841609
Molecular Formula
C18H18FN7O2
Formula Weight
383.38
MOL File
2120398-39-0.mol
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5-((5-(2-(3-aminopropoxy)-4-fluoro-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile Property

storage temp. 
Store at -20°C
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0134825
Product name
Chk1-IN-5
Packaging
250mg
Price
$360
Updated
2021/12/16
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5-((5-(2-(3-aminopropoxy)-4-fluoro-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile Chemical Properties,Usage,Production

Uses

Chk1-IN-5 is a potent checkpoint kinase 1 (Chk1) inhibitor. Chk1-IN-5 inhibits Chk1 phosphorylation and inhibits tumor growth in colon cancer xenograft model[1].

in vivo

Chk1-IN-5 (compound 3; 40 mg/kg; IV; twice a week for 21 days) inhibits tumor growth in Baib/c nude mice with HT-29 colon cancer cells[1].
Chk1-IN-5 (10 mg/kg; via tail vein intravenous injection) displays a longer half-life (T1/2=3.8 hours) and higher exposure (CL=2.3 L/hr?kg; Vss=6.4 L/kg; AUC=4531 ng/ml?h)[1].

Animal Model:Baib/c nude mice with HT-29 colon cancer cells[1]
Dosage:40 mg/kg
Administration:IV; twice a week for 21 days
Result:Inhibited tumor growth.
Animal Model:Male SD rats (280-350 g)[1]
Dosage:10 mg/kg
Administration:Via tail vein intravenous injection
Result:Displayed a longer half-life (T1/2=3.8 hours) and higher exposure (CL=2.3 L/hr?kg; Vss=6.4 L/kg; AUC=4531 ng/ml?h).

IC 50

Chk1

References

[1] Xiong Cai, et al. 3,5-disubstituted pyrazoles useful as checkpoint kinase 1 (chk1) inhibitors, and their preparations and applications. WO2017132928A1.

5-((5-(2-(3-aminopropoxy)-4-fluoro-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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5-((5-(2-(3-aminopropoxy)-4-fluoro-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile Suppliers

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2120398-39-0, 5-((5-(2-(3-aminopropoxy)-4-fluoro-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrileRelated Search:


  • 5-((5-(2-(3-aminopropoxy)-4-fluoro-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile
  • 2-Pyrazinecarbonitrile, 5-[[5-[2-(3-aminopropoxy)-4-fluoro-6-methoxyphenyl]-1H-pyrazol-3-yl]amino]-
  • Chk1-IN-5
  • Chk-1-IN-5,Chk1IN5,Chk1 IN 5
  • 2120398-39-0
  • C18H18FN7O2