Fmoc-Val-Ala-pAB-PNP
Uses In vitro Storage- Product Name
- Fmoc-Val-Ala-pAB-PNP
- CAS No.
- 1394238-92-6
- Chemical Name
- Fmoc-Val-Ala-pAB-PNP
- Synonyms
- (9H-Fluoren-9-yl)methyl ((S)-3-methyl-1-(((S)-1-((4-((((4-nitrophenoxy)carbonyl)oxy)methyl)phenyl)amino)-1-oxopropan-2-yl)amino)-1-oxobutan-2-yl)carbamate;Fmoc-Val-Ala-pAB-PNP;Fmoc-Val-Ala-pAB-PNP USP/EP/BP;4-[(S)-2-[(S)-2-(Fmoc-amino)-3-methylbutanamido]propanamido]benzyl (4-Nitrophenyl) Carbonate;L-Alaninamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valyl-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-;[4-[[(2S)-2-[[(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methylbutanoyl]amino]propanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate
- CBNumber
- CB64843825
- Molecular Formula
- C37H36N4O9
- Formula Weight
- 680.7
- MOL File
- 1394238-92-6.mol
Fmoc-Val-Ala-pAB-PNP Property
- Boiling point:
- 931.4±65.0 °C(Predicted)
- Density
- 1.322±0.06 g/cm3(Predicted)
- storage temp.
- Storage temp. 2-8°C
- form
- Solid
- pka
- 10.63±0.46(Predicted)
- color
- White to light yellow
- InChIKey
- QJUKCRRILOLECU-WYOOIXGGSA-N
- SMILES
- C(N)(=O)[C@H](C)N(C(=O)[C@H](C(C)C)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O)C1=CC=C(COC(OC2=CC=C([N+]([O-])=O)C=C2)=O)C=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- ADC1070
- Product name
- Fmoc-Val-Ala-PAB-PNP
- Packaging
- 100mg
- Price
- $168.75
- Updated
- 2021/12/16
- Product number
- ADC1070
- Product name
- Fmoc-Val-Ala-PAB-PNP
- Packaging
- 250mg
- Price
- $337.5
- Updated
- 2021/12/16
- Product number
- ADC1070
- Product name
- Fmoc-Val-Ala-PAB-PNP
- Packaging
- 1g
- Price
- $1012.5
- Updated
- 2021/12/16
- Product number
- A1353604
- Product name
- (9H-Fluoren-9-yl)methyl((S)-3-methyl-1-(((S)-1-((4-((((4-nitrophenoxy)carbonyl)oxy)methyl)phenyl)amino)-1-oxopropan-2-yl)amino)-1-oxobutan-2-yl)carbamate
- Purity
- 97%
- Packaging
- 100mg
- Price
- $218
- Updated
- 2021/12/16
- Product number
- A1353604
- Product name
- (9H-Fluoren-9-yl)methyl((S)-3-methyl-1-(((S)-1-((4-((((4-nitrophenoxy)carbonyl)oxy)methyl)phenyl)amino)-1-oxopropan-2-yl)amino)-1-oxobutan-2-yl)carbamate
- Purity
- 97%
- Packaging
- 250mg
- Price
- $375
- Updated
- 2021/12/16
Fmoc-Val-Ala-pAB-PNP Chemical Properties,Usage,Production
Uses
Fmoc-Val-Ala-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
In vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Description
Fmoc-Val-Ala-PAB-PNP can be used to design cleavable ADC linkers. The Val-Ala, as shown in the ACD Zynlonta, is effectively cleaved by lysosomal proteolytic enzymes while being highly stable in human plasma. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations.
Uses
Fmoc-Val-Ala-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
IC 50
Protease Cleavable Linker; Cleavable Linker
References
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268
Fmoc-Val-Ala-pAB-PNP Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Fmoc-Val-Ala-pAB-PNP manufacturers
- Product
- Fmoc-Val-Ala-PAB-PNP 1394238-92-6
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- >99.00%
- Supply Ability
- 1g
- Release date
- 2024-03-29