ChemicalBook > CAS DataBase List > BRD3308 (BRD 3308)

BRD3308 (BRD 3308)

Product Name: BRD3308 (BRD 3308)
CAS No.: 1550053-02-5
Chemical Name: BRD3308 (BRD 3308)
Synonyms: BRD3308;BRD3308 (BRD 3308);BRD3308 >=98% (HPLC);BRD3308, 10 mM in DMSO;4-Acetamido-N-(2-amino-4-fluorophenyl)benzamide;4-(Acetylamino)-N-(2-amino-4-fluorophenyl)benzamide;Benzamide, 4-(acetylamino)-N-(2-amino-4-fluorophenyl)-;β-cells,glucolipotoxicity,inflammatory,BRD-3308,Human immunodeficiency virus,BRD3308,Histone deacetylases,HDAC3,diabetes,HDAC,HIV-1,Inhibitor,Apoptosis,latency,BRD 3308,cytokines,hyperglycaemia,HIV,inhibit,insulin
CBNumber: CB64844594
Molecular Formula: C15H14FN3O2
Formula Weight: 287.29
MOL File: 1550053-02-5.mol

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BRD3308 (BRD 3308) Property

Boiling point:: 449.9±45.0 °C(Predicted)
Density: 1.382±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO:57.0(Max Conc. mg/mL);198.41(Max Conc. mM)
form: A solid
pka: 12.13±0.70(Predicted)
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1639
Product name: BRD3308
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $154
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1639
Product name: BRD3308
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $308
Updated: 2025/07/31

Biosynth Carbosynth

Product number: BB168411
Product name: BRD 3308
Packaging: 10mg
Price: $95
Updated: 2021/12/16

ChemScene

Product number: CS-0015975
Product name: BRD3308
Purity: 95.94%
Packaging: 10mg
Price: $160
Updated: 2021/12/16

AK Scientific

Product number: 4572DW
Product name: CID72734382
Packaging: 10mg
Price: $178
Updated: 2021/12/16

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BRD3308 (BRD 3308) Chemical Properties,Usage,Production

Uses

BRD3308 is a highly selective HDAC3 inhibitor with an IC50 of 54 nM. BRD3308 is 23-fold selectivity for HDAC3 over HDAC1 (IC50 of 1.26 μM) or HDAC2 (IC50 of 1.34 μM). BRD3308 suppresses pancreatic β-cell apoptosis induced by inflammatory cytokines or glucolipotoxic stress, and increases functional insulin release. BRD3308 activates HIV-1 transcription and disrupts HIV-1 latency[1][2][3].

Biological Activity

BRD3308 is a highly selective inhibitor of histone deacetylase 3 (HDAC3) with an IC50 value of 65 nM for HDAC3 vs. IC50 values of 1.08 μM and 1.15 μM for HDAC1 and HDAC2, respectively. BRD3308 protected pancreatic β cells, suppressing inflammatory cytokine-induced apoptosis and increasing insulin release without the toxicity associated with HDAC1 and HDAC2 inhibitors. In a r at model of type 2 diabetes, BRD3308 reduced hyperglycemia and increased insulin secretion without affecting weight gain. In another study, BRD3308 was found to activate HIV-1 transcription, disrupting HIV-1 latency.', 'BRD3308 promotes outgrowth of HIV-1 (human immunodeficiency virus 1) from inactive infected patient cells. It helps to increase β-cell proliferation.

in vivo

BRD3308 (5 mg/kg; intraperitoneal injection; every second day; male Zucker Diabetic Fatty rats) treatment reduces hyperglycaemia and increases insulin secretion in a rat model of type 2 diabetes. At the end of the hyperglycaemic clamp, circulating insulin levels are significantly higher in BRD3308-treated rats. Pancreatic insulin staining and contents are also significantly higher. BRD3308 preserves the functional β-cell mass against glucolipotoxicity in vivo^[2].

Animal Model:	Male Zucker Diabetic Fatty (Obese) rats (6-week-old)^[2]
Dosage:	5 mg/kg
Administration:	Intraperitoneal injection; every second day
Result:	Reduced hyperglycaemia and increased insulin secretion in a rat model of type 2 diabetes.

IC 50

HDAC3: 54 nM (IC₅₀); HDAC3: 29 nM (Ki); HDAC1: 1260 nM (IC₅₀); HDAC1: 5100 nM (Ki); HDAC2: 1340 nM (IC₅₀); HDAC2: 6300 nM (Ki); HIV-1

References

[1] Barton KM, et al. Selective HDAC inhibition for the disruption of latent HIV-1 infection. PLoS One. 2014 Aug 19;9(8):e102684. DOI:10.1371/journal.pone.0102684
[2] Lundh M, et al. Histone deacetylase 3 inhibition improves glycaemia and insulin secretion in obese diabetic rats. Diabetes Obes Metab. 2015 Jul;17(7):703-7. DOI:10.1111/dom.12470
[3] Wagner FF, et al. An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection. ACS Chem Biol. 2016 Feb 19;11(2):363-74. DOI:10.1021/acschembio.5b00640

BRD3308 (BRD 3308) Preparation Products And Raw materials

Raw materials

Preparation Products

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1550053-02-5, BRD3308 (BRD 3308)Related Search:

BRD3308 (BRD 3308)

4-(Acetylamino)-N-(2-amino-4-fluorophenyl)benzamide

BRD3308

Benzamide, 4-(acetylamino)-N-(2-amino-4-fluorophenyl)-

BRD3308 >=98% (HPLC)

4-Acetamido-N-(2-amino-4-fluorophenyl)benzamide

β-cells,glucolipotoxicity,inflammatory,BRD-3308,Human immunodeficiency virus,BRD3308,Histone deacetylases,HDAC3,diabetes,HDAC,HIV-1,Inhibitor,Apoptosis,latency,BRD 3308,cytokines,hyperglycaemia,HIV,inhibit,insulin

BRD3308, 10 mM in DMSO

1550053-02-5

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