DO-34 (DO34)

Product Name: DO-34 (DO34)
CAS No.: 1848233-58-8
Chemical Name: DO-34 (DO34)
Synonyms: DO-34 (DO34);1-Piperazinecarboxylic acid, 3-(phenylmethyl)-4-[[4-[4-(trifluoromethoxy)phenyl]-1H-1,2,3-triazol-1-yl]carbonyl]-, 1,1-dimethylethyl ester;DO34 3-(Phenylmethyl)-4-[[4-[4-(trifluoromethoxy)phenyl]-1H- 1,2,3-triazol-1-yl]carbonyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester
CBNumber: CB64844721
Molecular Formula: C26H28F3N5O4
Formula Weight: 531.53
MOL File: 1848233-58-8.mol

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DO-34 (DO34) Property

Boiling point:: 611.4±65.0 °C(Predicted)
Density: 1.32±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : ≥ 100 mg/mL (188.14 mM)
form: Solid
pka: -0.68±0.70(Predicted)
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

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DO-34 (DO34) Chemical Properties,Usage,Production

Biological Activity

DO34 is a brain-penetrant, selective and highly potent diacylglycerol lipase inhibitor (recom human DAGLα/β pIC50 = 8.2/8.1 by SAG hydrolysis; mouse brain DAGLα/β pIC50 = 9.1-9.3/8.6 by ABPP ReDiMe) with detectable off-target activity toward only ABHD6 & PLA2G7 among all mouse brain serine hydrolases and little affinity toward cannabinoid receptors CB1/2. DO34 blocks depolarization-induced suppression of excitation (DSE IC50 = 0.18 μM) and inhibition (100% DSI blockage at 1 μM) in mouse cerebellar and hippocampal slices ex vivo, and attenuate LPS-induced neuroinflammatory responses by lowering brain 2-AG & PGE2 level in mice in vivo (50 mg/kg, i.p).

DO-34 (DO34) Preparation Products And Raw materials

Raw materials

Preparation Products

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DO-34 (DO34) Suppliers

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1848233-58-8, DO-34 (DO34)Related Search:

DO-34 (DO34)

1-Piperazinecarboxylic acid, 3-(phenylmethyl)-4-[[4-[4-(trifluoromethoxy)phenyl]-1H-1,2,3-triazol-1-yl]carbonyl]-, 1,1-dimethylethyl ester

DO34 3-(Phenylmethyl)-4-[[4-[4-(trifluoromethoxy)phenyl]-1H- 1,2,3-triazol-1-yl]carbonyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester

1848233-58-8

C26H28F3N5O4