ChemicalBook > CAS DataBase List > DO-34
(DO34)
DO-34 (DO34)
- Product Name
- DO-34 (DO34)
- CAS No.
- 1848233-58-8
- Chemical Name
- DO-34 (DO34)
- Synonyms
- DO-34 (DO34);1-Piperazinecarboxylic acid, 3-(phenylmethyl)-4-[[4-[4-(trifluoromethoxy)phenyl]-1H-1,2,3-triazol-1-yl]carbonyl]-, 1,1-dimethylethyl ester;DO34 3-(Phenylmethyl)-4-[[4-[4-(trifluoromethoxy)phenyl]-1H- 1,2,3-triazol-1-yl]carbonyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester
- CBNumber
- CB64844721
- Molecular Formula
- C26H28F3N5O4
- Formula Weight
- 531.53
- MOL File
- 1848233-58-8.mol
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DO-34 (DO34) Property
- Boiling point:
- 611.4±65.0 °C(Predicted)
- Density
- 1.32±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 100 mg/mL (188.14 mM)
- form
- Solid
- pka
- -0.68±0.70(Predicted)
- color
- Off-white to light yellow
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DO-34 (DO34) Chemical Properties,Usage,Production
Biological Activity
DO34 is a brain-penetrant, selective and highly potent diacylglycerol lipase inhibitor (recom human DAGLα/β pIC50 = 8.2/8.1 by SAG hydrolysis; mouse brain DAGLα/β pIC50 = 9.1-9.3/8.6 by ABPP ReDiMe) with detectable off-target activity toward only ABHD6 & PLA2G7 among all mouse brain serine hydrolases and little affinity toward cannabinoid receptors CB1/2. DO34 blocks depolarization-induced suppression of excitation (DSE IC50 = 0.18 μM) and inhibition (100% DSI blockage at 1 μM) in mouse cerebellar and hippocampal slices ex vivo, and attenuate LPS-induced neuroinflammatory responses by lowering brain 2-AG & PGE2 level in mice in vivo (50 mg/kg, i.p).
DO-34 (DO34) Preparation Products And Raw materials
Raw materials
Preparation Products
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DO-34 (DO34) Suppliers
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- +1-781-999-5354 +1-00000000000
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- Country
- United States
- ProdList
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