ChemicalBook > CAS DataBase List > JSH 150

JSH 150

Product Name
JSH 150
CAS No.
2247481-21-4
Chemical Name
JSH 150
Synonyms
JSH 150);JSH-150 (JSH150;CDK,inhibit,Cyclin dependent kinase,Inhibitor,JSH150,JSH-150,JSH 150;4-(((4-(5-Chloro-2-((trans-4-((2-methoxyethyl)amino)cyclohexyl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile;2H-Pyran-4-carbonitrile, 4-[[[4-[5-chloro-2-[[trans-4-[(2-methoxyethyl)amino]cyclohexyl]amino]-4-pyridinyl]-2-thiazolyl]amino]methyl]tetrahydro-;4-(((4-(5-Chloro-2-((trans-4-((2-methoxyethyl)amino)cyclohexyl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile , JSH-150
CBNumber
CB64844943
Molecular Formula
C24H33ClN6O2S
Formula Weight
505.08
MOL File
2247481-21-4.mol
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JSH 150 Property

Boiling point:
692.2±65.0 °C(Predicted)
Density 
1.29±0.1 g/cm3(Predicted)
solubility 
DMSO:100.0(Max Conc. mg/mL);197.99(Max Conc. mM)
Ethanol:100.0(Max Conc. mg/mL);197.99(Max Conc. mM)
Water:100.0(Max Conc. mg/mL);197.99(Max Conc. mM)
pka
9.13±0.40(Predicted)
form 
Solid
color 
Light yellow to yellow
InChIKey
XSDZPPRQLIZLDG-IYARVYRRSA-N
SMILES
C1OCCC(CNC2=NC(C3C(Cl)=CN=C(N[C@@H]4CC[C@@H](NCCOC)CC4)C=3)=CS2)(C#N)C1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0014379
Product name
JSH-150
Purity
98.36%
Packaging
5mg
Price
$480
Updated
2021/12/16
ChemScene
Product number
CS-0014379
Product name
JSH-150
Purity
98.36%
Packaging
10mg
Price
$800
Updated
2021/12/16
ChemScene
Product number
CS-0014379
Product name
JSH-150
Purity
98.36%
Packaging
25mg
Price
$1650
Updated
2021/12/16
ChemScene
Product number
CS-0014379
Product name
JSH-150
Purity
98.36%
Packaging
50mg
Price
$2550
Updated
2021/12/16
ChemScene
Product number
CS-0014379
Product name
JSH-150
Purity
98.36%
Packaging
100mg
Price
$3800
Updated
2021/12/16
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JSH 150 Chemical Properties,Usage,Production

Uses

JSH-150 is a highly selective and potent inhibitor of CDK9.

in vivo

Treatment of JSH-150 at all dosages, i.e., 10, 20 and 30 mg/kg/day, can almost completely suppress the tumor progression in the first two weeks and does not affect the animal’s weight indicating that there is no general cytotoxicity at these doses. After stopping the treatment of JSH-150, the tumors of the animals treated with 10 mpk drug dosage start to grow again. However, this tumor recurrence is not observed in the 20 and 30 mpk dosage groups during the following week after administration of JSH-150 is stopped and p values are quantified on the 21st day, which are 0.042, 0.0035 and 0.0028, respectively. The PK properties of JSH-150 are evaluated in different species including mice, Sprague-Dawley rats and beagle dogs through intravenous injection and oral administration. JSH-150 is absorbed rapidly in dogs and mice (Tmax=1.33 h and 2.00 h respectively) but slowly in rats (Tmax=3.33 h). JSH-150 also displays different half-lives in three different species via oral administration (T1/2=1.55 h in mice, 3.37 h in rats and 20.37 h in dogs), which indicates that it is metabolized very slowly in dogs compared with mice and rats. In addition, JSH-150 exhibits acceptable bioavailability in mice, rats and dogs (F=45.01%, 45.10% and 39.15%, respectively). The PK properties indicated that JSH-150 is suitable for oral administration[1].

IC 50

CDK9/cyclinT1: 1 nM (IC50); CDK16/Cyclin Y: 292 nM (IC50); Cdk1/cyclin B: 1.34 μM (IC50); CDK14/Cyclin Y: 1.68 μM (IC50); CDK7/Cyclin H/MNAT1: 1.72 μM (IC50); cdk2/cyclin A: 2.86 μM (IC50); Cdk5/p25: 4.64 μM (IC50)

JSH 150 Preparation Products And Raw materials

Raw materials

Preparation Products

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JSH 150 Suppliers

China 52 United States 4 Global 56
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24960
Advantage
58
Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.
Tel
+86-027-59232304 15387063101
Email
1276242629@qq.com
Country
China
ProdList
9995
Advantage
58
Hubei Chuchang Chemical Co., Ltd
Tel
18 15623560702
Email
info@chuchangbiotech.com
Country
China
ProdList
162
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4817
Advantage
55
Twochem Co.Ltd
Tel
021-021-58111628 15800915896
Fax
QQ 3285589261
Email
sales@twochem.com
Country
China
ProdList
304
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
86249
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Shanghai Rechem science Co., Ltd.
Tel
021-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2990
Advantage
58
Shanghai Linka Biotechnology Co., Ltd.
Tel
18301977208 18301977208;
Fax
qq2126935757
Email
2126935757@qq.com
Country
China
ProdList
209
Advantage
55
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400-6387771-6039 18920764717
Email
sales@heowns.com
Country
China
ProdList
24418
Advantage
60

2247481-21-4, JSH 150Related Search:


  • JSH 150)
  • JSH-150 (JSH150
  • 2H-Pyran-4-carbonitrile, 4-[[[4-[5-chloro-2-[[trans-4-[(2-methoxyethyl)amino]cyclohexyl]amino]-4-pyridinyl]-2-thiazolyl]amino]methyl]tetrahydro-
  • 4-(((4-(5-Chloro-2-((trans-4-((2-methoxyethyl)amino)cyclohexyl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile
  • CDK,inhibit,Cyclin dependent kinase,Inhibitor,JSH150,JSH-150,JSH 150
  • 4-(((4-(5-Chloro-2-((trans-4-((2-methoxyethyl)amino)cyclohexyl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile , JSH-150
  • 2247481-21-4
  • C24H33ClN6O2S
  • API