2-CHLORO-5-HYDROXYBENZALDEHYDE
- Product Name
- 2-CHLORO-5-HYDROXYBENZALDEHYDE
- CAS No.
- 7310-94-3
- Chemical Name
- 2-CHLORO-5-HYDROXYBENZALDEHYDE
- Synonyms
- 2-CHLORO-5-HYDROXYBENZALDEHYDE;Benzaldehyde, 2-chloro-5-hydroxy-
- CBNumber
- CB6487162
- Molecular Formula
- C7H5ClO2
- Formula Weight
- 156.57
- MOL File
- Mol file
2-CHLORO-5-HYDROXYBENZALDEHYDE Property
- Melting point:
- 110.5-111.5 °C
- Boiling point:
- 272.4±20.0 °C(Predicted)
- Density
- 1.404±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- crystalline powder
- pka
- 8.80±0.18(Predicted)
- color
- Faint yellow/faint orange
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
N-Bromosuccinimide Price
- Product number
- C368225
- Product name
- 2-Chloro-5-hydroxybenzaldehyde
- Packaging
- 1g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- 2615-5-26
- Product name
- 2-Chloro-5-hydroxybenzaldehyde
- Packaging
- 1g
- Price
- $61
- Updated
- 2021/12/16
- Product number
- FC67157
- Product name
- 2-Chloro-5-hydroxybenzaldehyde
- Packaging
- 5G
- Price
- $87.5
- Updated
- 2021/12/16
- Product number
- FC67157
- Product name
- 2-Chloro-5-hydroxybenzaldehyde
- Packaging
- 10g
- Price
- $165
- Updated
- 2021/12/16
- Product number
- X2716
- Product name
- 2-Chloro-5-hydroxybenzaldehyde
- Packaging
- 5g
- Price
- $168
- Updated
- 2021/12/16
2-CHLORO-5-HYDROXYBENZALDEHYDE Chemical Properties,Usage,Production
Uses
2-Chloro-5-hydroxybenzaldehyde is used as a reagent in the synthesis of p38 inhibitors which are used for the treatment of chronic obstructive pulmonary disease. It is also used in the preparation of halogenated analogs of L-meta-tyrosine which is a biodegradable herbicide. 2-Chloro-5-hydroxybenzaldehyde may also be used as a starting material in the synthesis of chlorinated phenylephrine.
Synthesis
100-83-4
7310-94-3
56962-12-0
3-Hydroxybenzaldehyde (1 g, 10 mmol) was used as starting material and dissolved in acetonitrile (50 mL). To this solution, p-toluenesulfonic acid was added in batches at room temperature and after stirring for 5 minutes, N-chlorosuccinimide (NCS, 1.33 g, 10 mmol) was added. The reaction mixture was continued to be stirred at room temperature for 2 hours. Upon completion of the reaction, the reaction was quenched with aqueous sodium thiosulfate, followed by dilution with ethyl acetate and saturated saline. The organic layer was separated, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography with the eluent of petroleum ether/ethyl acetate (10:1 to 5:1) to afford 2-chloro-5-hydroxybenzaldehyde (Intermediate 28a, 340 mg, 21.7% yield) and 4-chloro-3-hydroxybenzaldehyde (Intermediate 28b, 310 mg, 19.7% yield) as yellow solids, respectively.The 1H NMR (CDCl3) data of 2-chloro-5-hydroxybenzaldehyde: δ10.43 (s, 1H), 7.54-7.56 (d, 1H), 7.30-7.37 (m, 2H). 1H-NMR (CDCl3) data of 4-chloro-3-hydroxybenzaldehyde: δ10.43 (s, 1H), 7.40 (d, 1H), 7.33 (d, 1H), 7.06- 7.09 (dd, 1H).
References
[1] Patent: WO2014/143799, 2014, A2. Location in patent: Page/Page column 391
[2] Patent: US2014/275528, 2014, A1. Location in patent: Paragraph 0322; 0323
2-CHLORO-5-HYDROXYBENZALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
2-CHLORO-5-HYDROXYBENZALDEHYDE Suppliers
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 010-59484199 18611897322
- sales@eternalchem.com
- Country
- China
- ProdList
- 4383
- Advantage
- 60
- Tel
- +86057186818502 13588463833
- Fax
- Pls mail us for more information!
- info@sagechem.com
- Country
- China
- ProdList
- 10266
- Advantage
- 58
- Tel
- 021-58170097
- info@topbiochem.com
- Country
- China
- ProdList
- 9514
- Advantage
- 58
- Tel
- 021-60343070
- Fax
- 021-35122006
- Country
- China
- ProdList
- 12740
- Advantage
- 55
- Tel
- +86-021-50935922
- Fax
- +86-021-33847795
- Country
- China
- ProdList
- 7865
- Advantage
- 55
- Tel
- +86-28-85122536 85324413
- Fax
- +86-28-85326443
- market@astatech.cn
- Country
- China
- ProdList
- 8026
- Advantage
- 55
- Tel
- 15121041756
- xingui2022@126.com
- Country
- China
- ProdList
- 9980
- Advantage
- 58
- Tel
- 0571-87396432
- Fax
- 0571-87396431
- sales@jhechem.com
- Country
- China
- ProdList
- 14912
- Advantage
- 59
- Tel
- 021-61478794
- Fax
- 021-61478794
- sales@hcshhai.com
- Country
- China
- ProdList
- 9793
- Advantage
- 50
View Lastest Price from 2-CHLORO-5-HYDROXYBENZALDEHYDE manufacturers
- Product
- 2-CHLORO-5-HYDROXYBENZALDEHYDE 7310-94-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-03