5,15-DIPHENYL-21H,23H-PORPHINE

ChemicalBook > CAS DataBase List > 5,15-DIPHENYL-21H,23H-PORPHINE

5,15-DIPHENYL-21H,23H-PORPHINE

Uses

Product Name: 5,15-DIPHENYL-21H,23H-PORPHINE
CAS No.: 22112-89-6
Chemical Name: 5,15-DIPHENYL-21H,23H-PORPHINE
Synonyms: 5,15-DPP;5,15-DIPHENYLPORPHINE;5,15-Diphenylporphyrin;5,15-Diphenylporphyrin>5, 15-BIS-(PHENYL)PORPHYRINS;5,15-DIPHENYL-21H,23H-PORPHINE;Stat3 Inhibitor VIII, 5,15-DPP;21H,23H-Porphine, 5,15-diphenyl-;5,15-Bis-(phenyl)-21H,23H-porphyrins;5,15-diphenyl-21,23-dihydroporphyrin
CBNumber: CB6487713
Molecular Formula: C32H22N4
Formula Weight: 462.54
MOL File: 22112-89-6.mol

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5,15-DIPHENYL-21H,23H-PORPHINE Property

Melting point:: >200℃
Boiling point:: 912.3±65.0 °C(Predicted)
Density: 1.285±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: ≤2mg/ml in dimethyl formamide
form: Deep blue to deep purple solid
color: Red to Dark blue to Black

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Safety

WGK Germany: 3
HS Code: 2933.99.8290
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D4071
Product name: 5, 15-DPP
Packaging: 10mg
Price: $87.5
Updated: 2024/03/01

Sigma-Aldrich

Product number: 573109
Product name: STAT3 Inhibitor VIII, 5,15-DPP
Packaging: 25mg
Price: $140
Updated: 2023/01/07

TCI Chemical

Product number: D2860
Product name: 5,15-Diphenylporphyrin
Purity: >90.0%(HPLC)
Packaging: 100mg
Price: $333
Updated: 2024/03/01

Cayman Chemical

Product number: 16090
Product name: 5, 15-DPP
Purity: ≥95%
Packaging: 10mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 16090
Product name: 5, 15-DPP
Purity: ≥95%
Packaging: 25mg
Price: $109
Updated: 2024/03/01

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5,15-DIPHENYL-21H,23H-PORPHINE Chemical Properties,Usage,Production

Uses

5,15-Diphenylporphyrin (cas# 22112-89-6) is a useful research chemical.

Biological Activity

5,15-diphenylporphyrin (5,15-dpp) is a selective stat3-sh2 antagonist [1].stat3 is constitutively activated in many human cancers. stat3 functions as a critical mediator of oncogenic signaling through transcriptional activation of genes encoding apoptosis inhibitors, cell-cycle regulators and inducers of angiogenesis [2]. aberrant stat3 activity has been associated with transforming mechanisms induced by oncogenic tyrosine kinases [1].

in vitro

5,15-dpp directly bound to stat3 and antagonized the function of stat3-sh2. 5,15-dpp selectively antagonized stat3-sh2 with an ic50 of 0.28 μm over the other sh2-containing proteins stat1 and grb2[1]. the estimated kd values for the 5,15-dpp binding to stat3 was 880 nm. treatment with 5,15-dpp suppressed the dna binding activity of stat3 in a concentration-dependent manner. 5,15-dpp poorly inhibited stat1 with an ic50 of 10 μm and showed no effect grb2 [1].

References

[1] uehara y, mochizuki m, matsuno k, et al. novel high-throughput screening system for identifying stat3–sh2 antagonists[j]. biochemical and biophysical research communications, 2009, 380(3): 627-631.
[2] jing n, tweardy d j. targeting stat3 in cancer therapy[j]. anti-cancer drugs, 2005, 16(6): 601-607.

5,15-DIPHENYL-21H,23H-PORPHINE Preparation Products And Raw materials

Raw materials

Preparation Products

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22112-89-6, 5,15-DIPHENYL-21H,23H-PORPHINERelated Search:

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5,15-Diphenylporphyrin

STAT3 Inhibitor VIII, 5,15-DPP - CAS 22112-89-6 - Calbiochem

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22112-89-6

C32H22N4

Porphyrins

Biochemistry

Porphyrins