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(S)-4-(4-Aminobenzyl)-2(1H)-oxazolidinone

Product Name
(S)-4-(4-Aminobenzyl)-2(1H)-oxazolidinone
CAS No.
152305-23-2
Chemical Name
(S)-4-(4-Aminobenzyl)-2(1H)-oxazolidinone
Synonyms
(S)-4-(4-AMINOBENZYL)-1,3-OXAZOLIDIN-2-ONE;(4S)-4-[(4-aMinophenyl)Methyl]-1,3-oxazolidin-2-one;ZTR 5;Zolmitriptan USP RC G;ZolMitriptan IMpurity A;Zolmitriptan Impurity E;Zomitriptan EP impurity E;Intermediate of zolmitriptan;Zolmitriptan Related Compound G;Zolmitriptan USP Related Compound G
CBNumber
CB6487869
Molecular Formula
C10H12N2O2
Formula Weight
192.21
MOL File
152305-23-2.mol
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(S)-4-(4-Aminobenzyl)-2(1H)-oxazolidinone Property

Melting point:
107-111 °C
Boiling point:
479.7±14.0 °C(Predicted)
Density 
1.257±0.06 g/cm3(Predicted)
refractive index 
-6.0 ° (C=1, MeOH)
storage temp. 
2-8°C
solubility 
Soluble in dimethyl sulfoxide and methanol.
pka
12.67±0.40(Predicted)
form 
Solid
color 
White to Brown
CAS DataBase Reference
152305-23-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26-36/37
WGK Germany 
2
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR3701
Product name
(<I>S</I>)-4-(4-Aminobenzyl)-2(1<I>H</I>)-oxazolidinone
Purity
certified reference material, pharmaceutical secondary standard
Packaging
50MG
Price
$470
Updated
2025/07/31
Sigma-Aldrich
Product number
658405
Product name
(S)-4-(4-Aminobenzyl)-2(1H)-oxazolidinone
Purity
97%
Packaging
10g
Price
$202
Updated
2025/07/31
Sigma-Aldrich
Product number
1727086
Product name
Zolmitriptan Related Compound G
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
25mg
Price
$1420
Updated
2025/07/31
TCI Chemical
Product number
A2095
Product name
(S)-4-(4-Aminobenzyl)-2-oxazolidinone
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$17
Updated
2024/03/01
TCI Chemical
Product number
A2095
Product name
(S)-4-(4-Aminobenzyl)-2-oxazolidinone
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$49
Updated
2024/03/01
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(S)-4-(4-Aminobenzyl)-2(1H)-oxazolidinone Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powde

Uses

Zolmitriptan intermediate

Uses

(S)-4-(4-Aminobenzyl)-2-(1H)-oxazolidinone is an intermediate of zolmitriptan (sc-220415) which acts as a novel inhibitor of the cytochrome P-450 enzyme aromatase.

Uses

An intermediate of Zolmitriptan, as a novel inhibitor of the cytochrome P-450 enzyme aromatase

Synthesis

726134-79-8

105-58-8

152305-23-2

General steps: 1. (S)-2-Amino-3-(4-aminophenyl)propanol (7.6 kg), diethyl carbonate (13.5 kg) and potassium carbonate (0.633 kg) were added to a reactor and reacted at 135°C. 2. Ethanol was distilled from the reaction mixture within 2.5 hrs. 3. After completion of the reaction, the reaction mixture was cooled to room temperature, methanol (35.0 kg) was added, the salt was removed by filtration through a filter aid and washed with methanol. 4. The methanol in the filtrate was completely distilled under vacuum and isopropanol (9.5 kg) was added to the residue. 5. the product was filtered through a filter aid and washed with isopropanol to give (S)-4-(4-aminobenzyl)-1,3-azolidin-2-one. 6. The product was dried under vacuum at 50 °C to give 6.85 kg (76.7% yield, melting point 95-100 °C). 7. The product was analyzed: molecular formula C10H12N2O2, molecular weight 192.0; IR spectrum (KBr): lactone peak 1759 cm-1; 1H NMR and 13C NMR were consistent with the expected structure. Note: Step B is the preparation of (S)-4-(4-aminobenzyl)-2-oxazolidinone, the specific operation is similar to that of Step A. Dimethyl carbonate was used instead of diethyl carbonate, and the reaction temperature was 115-120 ℃, and other conditions were the same.

References

[1] Patent: WO2004/63175, 2004, A1. Location in patent: Page 9; 12; 14; 16-18

(S)-4-(4-Aminobenzyl)-2(1H)-oxazolidinone Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-4-(4-Aminobenzyl)-2(1H)-oxazolidinone Suppliers

Americas 1 Canada 1 China 232 Europe 3 Germany 4 India 37 Japan 1 South Korea 1 Switzerland 2 United Kingdom 13 United States 34 Global 329
Beihua Chemical (Shandong) Co., LTD
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0531-68653689 13127106931
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1720760574@qq.com
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China
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J & K SCIENTIFIC LTD.
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86-10-82849933
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jkinfo@jkchemical.com
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+49 3493/605464
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+49 3493/605470
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sales@intatrade.de
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Germany
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View Lastest Price from (S)-4-(4-Aminobenzyl)-2(1H)-oxazolidinone manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Zolmitriptan EP Impurity E 152305-23-2
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
0.98
Supply Ability
10g
Release date
2024-04-25
Zhuozhou Wenxi import and Export Co., Ltd
Product
(S)-4-(4-Aminobenzyl)-2(1H)-oxazolidinone 152305-23-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Career Henan Chemical Co
Product
(S)-4-(4-Aminobenzyl)-2(1H)-oxazolidinone 152305-23-2
Price
US $200.00/KG
Min. Order
100G
Purity
98%
Supply Ability
1KG,5KG,10KG
Release date
2018-07-25

152305-23-2, (S)-4-(4-Aminobenzyl)-2(1H)-oxazolidinoneRelated Search:

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  • (4S)-4-[(4-AMINOPHENYL)METHYL]-2-OXAZOLIDINONE
  • (S)-4-(4'-AMINOBENZYL)-1,3-OXAZOLIDIN-2-ONE
  • (S)-4-(4-AMINOBENZYL)-1,3-OXAZOLIDIN-2-ONE
  • (S)-4-(4-AMINOBENZYL)-2(1H)-OXAZOLIDINONE
  • (S)-4-(4'-AMINOBENZYL)-2-OXAZOLIDINONE
  • (S)-4-(4-AMINOBENZYL)-2-OXAZOLIDINONE
  • (S)-4-(4-AMINO-BENZYL)-OXAZOLIDIN-2-ONE
  • (S)-4-(4-AMINO-BENZYL)-OXAZOLIDINE-2-ONE
  • Zolmitriptan Related Compound G
  • (S)-4-(4-Aminobenzyl)-2(1H)-oxazolidinone Cas 152305-23-2
  • (S)-4-(4-AMINOBENZYL)-2-OXAZOLIDINONE DIHCL
  • (S)-4-(4-AMINOBENZYL)-2(1H)-OXAZOLIDINO&
  • (S)-4-(4-AMINOBENZYL)-1,3-OXOZOLIDIN-2-ONE
  • (S)-4-(4-AMINOBENZYL)-1,3-OXAZOLIDIN-2-ONE(FOR ZOLMITRIPTAN)
  • (S)-4-[(4-Aminophenyl)-methyl]-oxazo-lidin-2(1H)-one
  • (S)-4-(4-Aminobenzyl)-1,3-oxazolidine-2-one
  • 4S)-4-(4-Aminobenzyl)-1,3-oxazolidin-2-one
  • ZTR 5
  • 2-Oxazolidinone, 4-[(4-aminophenyl)methyl]-, (4S)-
  • (s)-4-(4-Aminobenzyl)-1,3-oxazolidin-2-one ,≥99%
  • (S)-4-[(4-Amino Phenyl)-Methyl]-Oxazo-lidin-2(1H)-One&nbsp
  • (4S)-4-[(4-aMinophenyl)Methyl]-1,3-oxazolidin-2-one
  • ZolMitriptan IMpurity A
  • (S)-4-(4-AMinobenzyl)-1,3-oxazoladine-2-one
  • (S)-4-(4-Aminobenzyl)-2(1H)-oxazolidinone (4S)-4-[(4-Aminophenyl)methyl]-2-oxazolidinone
  • Zolmitriptan USP RC G
  • (S)-4-(4-Aminobenzyl)-2-oxazolidinone,99%e.e.
  • (S)-4-(4- Amido Phenyl)-1,3-Oxazolidin-2-One
  • Zolmitriptan USP Related Compound G
  • (S)-4-(4-Aminobenzyl)-2-oxazolidinone &gt
  • Zolmitriptan EP Impurity E (Zolmitriptan USP Related Compound G)
  • Zolmitriptan Impurity 9(Zolmitriptan USP RC G)
  • Zolmitriptan EP Impurity E/ Zolmitriptan Related Compound G
  • (S)-4-(4-Aminobenzyl)-1,3-oxazolidine-2-oneQ: What is (S)-4-(4-Aminobenzyl)-1,3-oxazolidine-2-one Q: What is the CAS Number of (S)-4-(4-Aminobenzyl)-1,3-oxazolidine-2-one Q: What is the storage condition of (S)-4-(4-Aminobenzyl)-1,3-oxazolidine-2-one Q: What are the applications of (S)-4-(4-Aminobenzyl)-1,3-oxazolidine-2-one
  • Zolmitriptan Related Compound G ((S)-4-(4-Aminobenzyl)oxazolidin-2-one) (1727086)
  • Zolmitriptan Impurity E
  • Zomitriptan EP impurity E
  • (S)-4-(4-Aminobenzyl)-2-oxazolidinone, ≥ 98.0%
  • (4S)-(4-AMINOBENZYL)-2-OXAZOLIDIN-2-ONE
  • (S)-4-(4- aminobenzyl)-1, 3-oxazoliden-2-one
  • (<i>S</i>)-4-(4-Aminobenzyl)-2(1<i>H</i>)-oxazolidinone
  • Intermediate of zolmitriptan
  • Zolmitriptan Imp.E (EP): (4S)-4-[(4-aminophenyl)methyl]-1,3-oxazolidin-2-one
  • Zolmitriptan Impurity 9(Zolmitriptan USP RC G)(Zolmitriptan EP Impurity E)
  • 152305-23-2
  • Asymmetric Synthesis
  • Chiral Auxiliaries
  • Oxazolidinone Derivatives
  • INTERMEDIATESOFZOLMITRIPTAN
  • chiral
  • Chiral Reagents
  • Asymmetric Synthesis
  • Chiral Building Blocks
  • Glycidyl Compounds, etc. (Chiral)
  • Synthetic Organic Chemistry
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • API's