ChemicalBook > CAS DataBase List > AMG PERK 44

AMG PERK 44

Product Name
AMG PERK 44
CAS No.
1883548-84-2
Chemical Name
AMG PERK 44
Synonyms
AMG PERK 44;4-(2-Amino-4-methyl-3-(2-methylquinolin-6-yl)benzoyl)-1-methyl-2,5-diphenyl-1,2-dihydro-3H-pyrazol-3-one hydrochloride;4-(2-Amino-4-methyl-3-(2-methylquinolin-6-yl)benzoyl)-1-methyl-2,5-diphenyl-1,2-dihydro-3H-pyrazol-3-one hydrochloride , AMG PERK 44
CBNumber
CB64919953
Molecular Formula
C34H29ClN4O2
Formula Weight
561.08
MOL File
1883548-84-2.mol
More
Less

AMG PERK 44 Property

storage temp. 
Store at -20°C
solubility 
DMSO: 25 mg/mL (44.56 mM)
form 
Solid
color 
Light yellow to yellow
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Tocris
Product number
5517
Product name
AMGPERK44
Purity
≥98%(HPLC)
Packaging
50
Price
$1110
Updated
2021/12/16
TRC
Product number
A576585
Product name
AMGPERK44
Packaging
1mg
Price
$130
Updated
2021/12/16
ChemScene
Product number
CS-0033295
Product name
AMGPERK44
Purity
99.17%
Packaging
5mg
Price
$150
Updated
2021/12/16
ChemScene
Product number
CS-0033295
Product name
AMGPERK44
Purity
99.17%
Packaging
10mg
Price
$250
Updated
2021/12/16
ChemScene
Product number
CS-0033295
Product name
AMGPERK44
Purity
99.17%
Packaging
50mg
Price
$950
Updated
2021/12/16
More
Less

AMG PERK 44 Chemical Properties,Usage,Production

Uses

AMG PERK 44 is a potent and selective PERK inhibitor.

in vivo

AMG PERK 44 (orally; 3-100 mg/kg) robustly inhibits PERK autophosphorylation in this assay (ED50=3 mg/kg; ED90=60 mg/kg at the 4 hours time point), and >50% target coverage is maintained for 24 h in a time course PD assay when dosed at 100 mg/kg po[1].
AMG PERK 44 (iv; 1 mg/kg) has a CL of 1.6 L/hkg, a Vss of 3.6 L/kg and MRT of 2.3 hours in Sprague-Dawley rats and male CD-1 mice[1].

Animal Model:Four- to six-week old naive athymic nude mice[1]
Dosage:3, 10, 30, 100 mg/kg
Administration:Orally
Result:Robustly inhibited PERK autophosphorylation in this assay (ED50=3 mg/kg; ED90=60 mg/kg at the 4 hours time point).
Animal Model:Sprague-Dawley rats and male CD-1 mice[1]
Dosage:1 mg/kg (Pharmacokinetic Analysis)
Administration:Iv
Result:Had a CL of 1.6 L/hkg, a Vss of 3.6 L/kg and a MRT of 2.3 hours.

storage

Store at -20°C

AMG PERK 44 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

AMG PERK 44 Suppliers

China 28 India 1 United States 6 USA 1 Global 36
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9025
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32469
Advantage
58
Zhejiang J&C Biological Technology Co.,Limited
Tel
+1-2135480471 +1-2135480471;
Email
sales@sarms4muscle.com
Country
China
ProdList
10473
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Suzhou Chenrui Biotechnology Co. LTD
Tel
17625585511
Fax
qq：1580084073
Email
1580084073@qq.com
Country
China
ProdList
999
Advantage
58
ShangHai ChuanQian Chemcial Technique Centre
Tel
15869524721
Email
3525679403@qq.com
Country
China
ProdList
4998
Advantage
58
Chunchuang (Wuhan) Technology Co., Ltd
Tel
15727060112
Email
yutianchun2007@126.com
Country
China
ProdList
9835
Advantage
58
cjbscvictory
Tel
13348960310 13348960310;
Email
3003867561@qq.com
Country
China
ProdList
10503
Advantage
58

1883548-84-2, AMG PERK 44Related Search:


  • AMG PERK 44
  • 4-(2-Amino-4-methyl-3-(2-methylquinolin-6-yl)benzoyl)-1-methyl-2,5-diphenyl-1,2-dihydro-3H-pyrazol-3-one hydrochloride , AMG PERK 44
  • 4-(2-Amino-4-methyl-3-(2-methylquinolin-6-yl)benzoyl)-1-methyl-2,5-diphenyl-1,2-dihydro-3H-pyrazol-3-one hydrochloride
  • 1883548-84-2