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AMG PERK 44

Product Name
AMG PERK 44
CAS No.
1883548-84-2
Chemical Name
AMG PERK 44
Synonyms
AMG PERK 44;4-(2-Amino-4-methyl-3-(2-methylquinolin-6-yl)benzoyl)-1-methyl-2,5-diphenyl-1,2-dihydro-3H-pyrazol-3-one hydrochloride;4-(2-Amino-4-methyl-3-(2-methylquinolin-6-yl)benzoyl)-1-methyl-2,5-diphenyl-1,2-dihydro-3H-pyrazol-3-one hydrochloride , AMG PERK 44
CBNumber
CB64919953
Molecular Formula
C34H29ClN4O2
Formula Weight
561.08
MOL File
1883548-84-2.mol
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AMG PERK 44 Property

storage temp. 
Store at -20°C
solubility 
DMSO: 25 mg/mL (44.56 mM)
form 
Solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
5517
Product name
AMGPERK44
Purity
≥98%(HPLC)
Packaging
50
Price
$1110
Updated
2021/12/16
TRC
Product number
A576585
Product name
AMGPERK44
Packaging
1mg
Price
$130
Updated
2021/12/16
ChemScene
Product number
CS-0033295
Product name
AMGPERK44
Purity
99.17%
Packaging
5mg
Price
$150
Updated
2021/12/16
ChemScene
Product number
CS-0033295
Product name
AMGPERK44
Purity
99.17%
Packaging
10mg
Price
$250
Updated
2021/12/16
ChemScene
Product number
CS-0033295
Product name
AMGPERK44
Purity
99.17%
Packaging
50mg
Price
$950
Updated
2021/12/16
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AMG PERK 44 Chemical Properties,Usage,Production

Uses

AMG PERK 44 is a potent and selective PERK inhibitor.

in vivo

AMG PERK 44 (orally; 3-100 mg/kg) robustly inhibits PERK autophosphorylation in this assay (ED50=3 mg/kg; ED90=60 mg/kg at the 4 hours time point), and >50% target coverage is maintained for 24 h in a time course PD assay when dosed at 100 mg/kg po[1].
AMG PERK 44 (iv; 1 mg/kg) has a CL of 1.6 L/h?kg, a Vss of 3.6 L/kg and MRT of 2.3 hours in Sprague-Dawley rats and male CD-1 mice[1].

Animal Model:Four- to six-week old naive athymic nude mice[1]
Dosage:3, 10, 30, 100 mg/kg
Administration:Orally
Result:Robustly inhibited PERK autophosphorylation in this assay (ED50=3 mg/kg; ED90=60 mg/kg at the 4 hours time point).
Animal Model:Sprague-Dawley rats and male CD-1 mice[1]
Dosage:1 mg/kg (Pharmacokinetic Analysis)
Administration:Iv
Result:Had a CL of 1.6 L/h?kg, a Vss of 3.6 L/kg and a MRT of 2.3 hours.

storage

Store at -20°C

AMG PERK 44 Preparation Products And Raw materials

Raw materials

Preparation Products

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AMG PERK 44 Suppliers

China 26 India 1 United States 6 USA 1 Global 34
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32470
Advantage
58
Zhejiang J&C Biological Technology Co.,Limited
Tel
+1-2135480471 +1-2135480471;
Email
sales@sarms4muscle.com
Country
China
ProdList
10473
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Suzhou Chenrui Biotechnology Co. LTD
Tel
17625585511
Fax
qq：1580084073
Email
1580084073@qq.com
Country
China
ProdList
969
Advantage
58
ShangHai ChuanQian Chemcial Technique Centre
Tel
15869524721
Email
3525679403@qq.com
Country
China
ProdList
4990
Advantage
58
Chunchuang (Wuhan) Technology Co., Ltd
Tel
15727060112
Email
yutianchun2007@126.com
Country
China
ProdList
9811
Advantage
58
cjbscvictory
Tel
13348960310
Email
3003867561@qq.com
Country
China
ProdList
10503
Advantage
58
Zhengzhou convergence chemical co., LTD
Tel
0371-0371-55153829 18003835034
Email
2853979819@qq.com
Country
China
ProdList
9998
Advantage
58

1883548-84-2, AMG PERK 44Related Search:


  • AMG PERK 44
  • 4-(2-Amino-4-methyl-3-(2-methylquinolin-6-yl)benzoyl)-1-methyl-2,5-diphenyl-1,2-dihydro-3H-pyrazol-3-one hydrochloride , AMG PERK 44
  • 4-(2-Amino-4-methyl-3-(2-methylquinolin-6-yl)benzoyl)-1-methyl-2,5-diphenyl-1,2-dihydro-3H-pyrazol-3-one hydrochloride
  • 1883548-84-2