L-Glutamic acid γ-(4-nitroanilide)

Product Name: L-Glutamic acid γ-(4-nitroanilide)
CAS No.: 7300-59-6
Chemical Name: L-Glutamic acid γ-(4-nitroanilide)
Synonyms: UTAMYL;GLU-PNA;Glu-4NA;ST5307107;110893-27-1;G1135_SIGMA;-p-NITROANIL;H-GLU(PNA)-OH;GPNA/H-Glu-PNA;EINECS 230-748-5
CBNumber: CB6496764
Molecular Formula: C11H13N3O5
Formula Weight: 267.24
MOL File: 7300-59-6.mol

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L-Glutamic acid γ-(4-nitroanilide) Property

Melting point:: 185-188°C
alpha: [α]D20 +36～+39°(c=2,dil.HCl)
Boiling point:: 590.6±50.0 °C(Predicted)
Density: 1.463
refractive index: 32 ° (C=2, 0.5mol/L HCl)
storage temp.: 2-8°C
solubility: Aqueous Acid (Slightly)
form: Solid
pka: 2.21±0.10(Predicted)
color: White to Pale Yellow
BRN: 2818758
InChI: InChI=1S/C11H13N3O5/c12-10(15)6-5-9(11(16)17)13-7-1-3-8(4-2-7)14(18)19/h1-4,9,13H,5-6H2,(H2,12,15)(H,16,17)/t9-/m0/s1
InChIKey: IMTMBDXEKMXETQ-VIFPVBQESA-N
SMILES: C(O)(=O)[C@H](CCC(N)=O)NC1=CC=C([N+]([O-])=O)C=C1
CAS DataBase Reference: 7300-59-6(CAS DataBase Reference)
EPA Substance Registry System: L-Glutamine, N-(4-nitrophenyl)- (7300-59-6)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
TSCA: Yes
HS Code: 29242990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: G1135
Product name: L-Glutamic acid γ-(4-nitroanilide)
Purity: γ-glutamyl transpeptidase substrate
Packaging: 1g
Price: $107
Updated: 2024/03/01

Sigma-Aldrich

Product number: G1135
Product name: L-Glutamic acid γ-(4-nitroanilide)
Purity: γ-glutamyl transpeptidase substrate
Packaging: 5g
Price: $426
Updated: 2024/03/01

TCI Chemical

Product number: G0065
Product name: L-gamma-Glutamyl-p-nitroanilide Monohydrate
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $122
Updated: 2024/03/01

TCI Chemical

Product number: G0065
Product name: L-gamma-Glutamyl-p-nitroanilide Monohydrate
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $412
Updated: 2024/03/01

Alfa Aesar

Product number: A14442
Product name: gamma-L-Glutamyl-4-nitroanilide, 98+%
Packaging: 1g
Price: $46.5
Updated: 2021/12/16

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L-Glutamic acid γ-(4-nitroanilide) Chemical Properties,Usage,Production

Description

L-Glutamic acid γ-(4-nitroanilide) is a substrate for γ-glutamyltransferase (GGT). It is an important enzyme that is widely used in biocatalysis and clinical diagnostics.

Chemical Properties

cream coloured to light yellow powder

Uses

Substrate for gamma-glutamyl transpeptidase

Preparation

To a microwave vial containing a solution of Boc-L-glutamic acid tert-butyl ester (0.165 mmol, 1.0 equiv) and HATU (0.165 mmol, 1.0 equiv) in DMF (1.65 mL) was added the amine followed by DIPEA (57.5 μL, 2.0 equiv). The vial was sealed and heated under microwave irradiation for 30 min at 120 °C. Upon completion, the reaction was partitioned between water and CH2Cl2, extracted 3× with CH2Cl2, dried over anhydrous Na2SO4, and concentrated under vacuum. Compounds were purified via reverse phase chromatography (5-95% acetonitrile/water) to afford the N-Boc-glutamylanilide-tert-butyl esters. The compounds were transferred to vials followed by the addition of 2.0 mL of 4.0 M HCl in dioxane. The reaction stirred at 40 °C for 4 h. The reactions were concentrated under vacuum to afford L-Glutamic acid γ-(4-nitroanilide).

Solubility in water

Soluble in water, formic acid (50 mg/ml), and 0.5mol/l hydrochloric acid. Chloroform: Slightly soluble. DMF: Slightly soluble. DMSO: Slightly soluble. Ethanol: Slightly soluble. Methanol: Slightly soluble. PBS (pH 7.2): Slightly soluble

L-Glutamic acid γ-(4-nitroanilide) Preparation Products And Raw materials

Raw materials

Preparation Products

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L-Glutamic acid γ-(4-nitroanilide) Suppliers

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7300-59-6, L-Glutamic acid γ-(4-nitroanilide)Related Search:

L-Glutamine GAMMA-L-GLUTAMYL-P-NITROANILIDE HYDRATE,GAMMA-L-GLUTAMYL P-NITROANILIDE, MONOHYDRATE DL-Glutamine L-Ornithine L-GLUTAMIC ACID GAMMA-(3-CARBOXY-4-NITROANILIDE) AMMONIUM SALT N-(4-Nitrophenyl)propionamide L-Glutamic acid γ-(4-nitroanilide) N-(4-Aminophenyl)propanamide 4-Nitroaniline H-GLU-PNA GAMMA-L-GLUTAMYL-4-NITROANILIDE HYDROCHLORIDE N-(4-AMINOPHENYL)PENTANAMIDE N-(4-AMINOPHENYL)BUTANAMIDE GAMMA-L-GLUTAMYL-P-NITROANILIDE HYDROCHLORIDE DL-GLUTAMIC ACID GAMMA-ANILIDE H-GLU(ANILIDE)-OH

L-gamma-Glutamyl-p-nitroanilide&nbsp

<small>L</small>-&gamma

-Glutamyl-<i>p</i>-nitroanilide Monohydrate

gamma-glutamine-4-nitroanilide

L-GLUTAMIC ACID 5-(4-NITROANILIDE)

L-GAMMA-GLUTAMYL-P-NITROANILIDE

GLUTAMIC ACID(PNA)-OH

H-GLU(PNA)-OH

GAMMA-L-GLU-P-NITROANILIDE

GAMMA-L-GLUTAMYL-4-NITROANILIDE

GAMMA-L-GLUTAMYL-P-NITROANILIDE

GLU-PNA

L-Glutamic acid 5-(4-nitroanilide) monohydrate

L-γ-Glutamyl-p-nitroanilide monohydrate≥ 98% (HPLC)

L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE)*F REE BASE

gamma-L-Glutamyl-4-nitroanilide, 98.5%

L-Glutamine, N-(4-nitrophenyl)-

l-glutamic acid γ-(4-nitroanilide)

N-(4-nitrophenyl)-L-glutamine

g-L-Glutamyl-4-nitroanilide

^y-L-Glutamyl-4-nitroanilide, 98+%

L-gamma-Glutamyl-p-nitroanilide monohydrate,98%

gamma-L-Glutamyl-4-nitroanilide, 98+%

GaMMa - L - glutaMine paranitroaniline a hydrate

L-gaMMa- glutaMyl - on - nitroaniline

L-Glutamyl-4-nitroanilide N-(4-Nitrophenyl)-L-glutamine

(2S)-2-amino-5-[(4-nitrophenyl)amino]-5-oxopentanoic acid

(2S)-2-amino-5-[(4-nitrophenyl)amino]-5-oxo-pentanoic acid

(2S)-2-amino-5-keto-5-[(4-nitrophenyl)amino]valeric acid

(2S)-2-azaniumyl-5-[(4-nitrophenyl)amino]-5-oxopentanoate

L-γ-GlutaMyl-p-nitroanilide Monohydrate

(S)-2-AMino-5-((4-nitrophenyl)aMino)-5-oxopentanoic acid

L-GlutaMy-4-nitroanilide MoMhydrate

110893-27-1

EINECS 230-748-5

G1135_SIGMA

L-2-Amino-4'-nitroglutaranilic acid

L-Glutamic acid gamma-(4-nitroanilide)

N~5~-(4-nitrophenyl)glutamine

ST5307107

GPNA/H-Glu-PNA

nomega-(4-nitrophenyl)-l-glutamine

L-Y-GLUTAMIC ACID-P-NITROANILIDE MONOHYDRATE

γ-L-Glutamyl-4-nitroanilide, 98+%

gamma-glutamyl-p-nitroanilide

L-γ-Glutamyl-p-nitroanilide, L-Glutamic acid 5-(4-nitroanilide)

Glu-4NA

L-Gulutamic acid γ-p-nitroanilide

γ-Glutamyl-p-nitroanilide

GPNA, L-γ-Glutamyl-p-nitroanilide

L-Gulutamic Acid

L-γ-Glutamyl-p-nitroanilideMonohydrate&gt

-p-NITROANIL

UTAMYL

γ-L-GLUTAMYL-p-NITROANILIDE

Nω-(4-Nitrophenyl)-L-glutamine Monohydrate

γ-L-Glutamyl-Pnitroanilide monohydrate

L-Glutamic acid gamma-(4-nitroanilide) gamma-glutamyl transpeptidase substrate