5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM
- Product Name
- 5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM
- CAS No.
- 148892-91-5
- Chemical Name
- 5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM
- Synonyms
- UQABYHGXWYXDTK-QXQKWMGSSA-N;Guanosine 5′-[β,γ-imido]triphosphate;5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM;Guanylyl Imidodiphosphate (trisodium);5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM;Guanylyl Imidodiphosphate Trisodium Salt;β:γ-imidoguanosine 5'-triphosphate trisodium salt;GUANOSINE-5-[(B GAMMA)-IMIDO]TRIPHOSPHATE SODIU...;guanosine 5'-[β,γ-imido]triphosphate trisodium salt;5′-Guanylyl-imidodiphosphate trisodium salt hydrate
- CBNumber
- CB6497387
- Molecular Formula
- C10H18N6NaO13P3
- Formula Weight
- 546.19
- MOL File
- 148892-91-5.mol
5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM Property
- storage temp.
- -70°C
- solubility
- H2O: 50 mg/mL
- form
- powder
- color
- white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- G0635
- Product name
- Guanosine 5′-[β,γ-imido]triphosphate trisodium salt hydrate
- Purity
- ≥85% (HPLC), powder
- Packaging
- 5mg
- Price
- $178
- Updated
- 2024/03/01
- Product number
- G0635
- Product name
- Guanosine 5′-[β,γ-imido]triphosphate trisodium salt hydrate
- Purity
- ≥85% (HPLC), powder
- Packaging
- 25mg
- Price
- $624
- Updated
- 2024/03/01
- Product number
- 16880
- Product name
- Guanylyl Imidodiphosphate
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $35
- Updated
- 2021/12/16
- Product number
- 16880
- Product name
- Guanylyl Imidodiphosphate
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $105
- Updated
- 2021/12/16
- Product number
- G0635
- Product name
- Guanosine 5′-[β,γ-imido]triphosphate trisodium salt hydrate
- Purity
- ≥85% (HPLC), powder
- Packaging
- 100mg
- Price
- $2000
- Updated
- 2024/03/01
5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM Chemical Properties,Usage,Production
Uses
Non-hydrolyzable analog of GTP; the preferred GTP analog to activate ADP-ribosylation factor.
Uses
Guanosine 5′-[β,γ-imido]triphosphate trisodium salt hydrate has been used: to study K-RAS interactions with the membrane, for the crystallization of Mycobacterium tuberculosis FtsZ, as a translation initiation inhibitor for the analysis of the 48S pre-initiation complex.
General Description
Guanosine 5′-[β,γ-imido]triphosphate (GMP-PNP, Gpp(NH)p) is a non-hydrolyzable analog of GTP that binds and irreversibly activates G proteins. Gpp(NH)p is used in a variety of applications that involve GTP binding, including GTP-activation, GTP-inhibition, GTP transport, GTP hydrolysis, and GTP structure stabilization. Since a cycle of GTP binding, hydrolysis, and release is required for the initiation of protein translocation across the endoplasmic reticulum, guanosine 5′-[β,γ-imido]triphosphate is often used in studies of protein synthesis. Gpp(NH)p is used to activate ADP-ribosylation factors and to modulate G proteins involved in cell signaling, protein synthesis and other metabolic processes.
Biochem/physiol Actions
Guanosine 5′-[?,γ-imido]triphosphate binds and irreversibly activates G proteins. Since a cycle of GTP binding, hydrolysis, and release is required for the initiation of protein translocation across the endoplasmic reticulum, this non-hydrolyzable GTP analog is often used in studies of protein synthesis.
5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM Preparation Products And Raw materials
Raw materials
Preparation Products
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