BH3I-1
- Product Name
- BH3I-1
- CAS No.
- 300817-68-9
- Chemical Name
- BH3I-1
- Synonyms
- BHI1;BHI1;BH 3I1;BH3I 1 ;BH3I1;5-(p-Bromobenzylidine)-α-isopropyl-4-oxo-2-thioxo-3-thiozolidineacetic acid;5-(p-Bromobenzylidene)-a-isopropyl-4-oxo-2-thioxo-3-thiazolidine acetic acid;2-(5-(4-Bromobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-3-methylbutanoic acid;3-Thiazolidineacetic acid, 5-[(4-bromophenyl)methylene]-α-(1-methylethyl)-4-oxo-2-thioxo-;MDM-2/p53,BH3I 1,Inhibitor,Ubiquitin ligase,BH3I-1,E3 ligating enzyme,Ubiquitin conjugating enzyme,BH3I1,E2 conjugating enzyme,Bcl-2 Family,BHI 1,E1 activating enzyme,inhibit,BHI-1,BH 3I1,E1/E2/E3 Enzyme,Ubiquitin activating enzyme,BH-3I-1
- CBNumber
- CB6497943
- Molecular Formula
- C15H14BrNO3S2
- Formula Weight
- 400.31
- MOL File
- 300817-68-9.mol
BH3I-1 Property
- Boiling point:
- 535.2±60.0 °C(Predicted)
- Density
- 1?+-.0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- DMSO: >10 mg/mL, soluble
- form
- powder, yellow
- pka
- 3.39±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
N-Bromosuccinimide Price
- Product number
- B8809
- Product name
- BH3I-1
- Purity
- ≥97% (HPLC), powder, yellow
- Packaging
- 5mg
- Price
- $242
- Updated
- 2024/03/01
- Product number
- 18763
- Product name
- BH3I-1
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 18763
- Product name
- BH3I-1
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $183
- Updated
- 2024/03/01
- Product number
- 18763
- Product name
- BH3I-1
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $321
- Updated
- 2024/03/01
- Product number
- 18763
- Product name
- BH3I-1
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $692
- Updated
- 2024/03/01
BH3I-1 Chemical Properties,Usage,Production
Description
The family of Bcl-2 proteins plays pivotal roles in either promoting or preventing apoptosis. Bcl-2 family members contain one or more of four characteristic Bcl-2 homology (BH) domains, which are crucial for function. For example, anti-apoptotic Bcl-2 family proteins prevent death signaling by heterodimerizing with pro-death proteins at their BH3 domains. BH3I-1 is a cell permeable inhibitor that blocks the binding of BH3 peptides to Bcl-xL, inducing apoptosis. It inhibits interactions of BH3 domain-containing proteins with Bcl-xL, Bcl-2, and Bcl-W, inducing apoptosis in Bcl-2 or Bcl-W expressing cells with Ki values of 43.4 and 124 μM, respectively. BH3I-1 enhances radiation sensitivity in non-small cell lung cancer cells.
Uses
BH3I-1 is a BH3 mimetic that binds to Bcl-xL.
in vitro
the bcl-2 inhibitors bh3i-1 and it analog bh3i-2 had been applied as lead compounds to find possible bcl-2 or bcl-x(l) inhibitors by using computer-assisted screening of in-house database. the identified compounds were further studied regarding their possible application as a drug. it was found that the induction of apoptosis, which was shown as number of hypodiploid cells, was increased by adding bh3i-1 and it analog bh3i-2 to bjab bcl-xl and bjab neo/mock cells. in addition, the effects of the pro-apoptotic proteins bax and bak on the induction of apoptosis via bh3i-1 and it analog bh3i-2 were investigated with a variety of knockout cell lines, and resulted showed that the presence or absence of bak or bax has no significant influence on the amount of apoptotic events induced by bh3i-1 and it analog bh3i-2 [1].
IC 50
293.95 μm
References
[1] füllbeck m,gebhardt n,hossbach j,daniel pt,preissner r. computer-assisted identification of small-molecule bcl-2 modulators. comput biol chem.2009 dec;33(6):451-6.
BH3I-1 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from BH3I-1 manufacturers
- Product
- BH3I-1 300817-68-9
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 20kg
- Release date
- 2019-12-23