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OLPRINONE HYDROCHLORIDE

Product Name
OLPRINONE HYDROCHLORIDE
CAS No.
119615-63-3
Chemical Name
OLPRINONE HYDROCHLORIDE
Synonyms
e1020;Coretec;OLPRINONE HCL;xo-,monohydrochloride,monohydrate;Olprinone hydrochloride - Loprinone hydrochloride;3-pyridinecarbonitrile,1,2-dihydro-5-(imidazo(1,2-a)pyridin-6-yl)-6-methyl-2-o;1,2-Dihydro-5-imidazo[1,2-α]pyridin-6-yl-6-methyl-2-oxo-3-pyridinecarbonitrile Hydrochloride;3-Pyridinecarbonitrile,1,2-dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-,monohydrochloride;Loprinone hydrochloride, 1,2-Dihydro-5-(imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-3-pyridinecarbonitrile hydrochloride
CBNumber
CB6504070
Molecular Formula
C14H11ClN4O
Formula Weight
286.72
MOL File
119615-63-3.mol
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OLPRINONE HYDROCHLORIDE Property

Melting point:
>3000C
storage temp. 
2-8°C
solubility 
DMSO: ≤4 mg/mL
form 
solid
color 
beige
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
2
RTECS 
US4201450
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
O7389
Product name
Olprinone hydrochloride
Purity
≥98% (HPLC), solid
Packaging
10mg
Price
$214
Updated
2022/05/15
Sigma-Aldrich
Product number
O7389
Product name
Olprinone hydrochloride
Purity
≥98% (HPLC), solid
Packaging
50mg
Price
$818
Updated
2022/05/15
Cayman Chemical
Product number
28396
Product name
Olprinone (hydrochloride)
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
28396
Product name
Olprinone (hydrochloride)
Packaging
25mg
Price
$456
Updated
2024/03/01
Cayman Chemical
Product number
28396
Product name
Olprinone (hydrochloride)
Packaging
5mg
Price
$122
Updated
2024/03/01
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OLPRINONE HYDROCHLORIDE Chemical Properties,Usage,Production

Description

Coatec was launched in Japan for acute cardiac insufficiency in cases resistant to other treatments. There are three related synthetic routes, 5-6 steps each, to loprinone all converging on 1-(imidazo[1,2a]pyridyl-6-yl)-Zpropanone as an advanced intermediate. It is a potent and selective inhibitor of PDE Ⅲ and a long lasting, orally active, positive inotropic agent. The PDE Ⅲ inhibition caused increased levels of CAMP which leads to the positive inotropic effect that was not altered by β or H2-preceptor antagonists. It was 100 times less potent at PDE I and PDE Ⅱ with no Na-K-ATPase activity. Improved hemodynamic parameters with slight changes in heart rate and blood pressure were seen in vivo. It is not mutagenic and its primary metabolite was less active.

Chemical Properties

Off-White Crystalline Powder

Originator

Eisai (Japan)

Uses

Inotropic agent which inhibits cAMP phosphodiesterase. Cardiotonic.

Definition

ChEBI: Olprinone hydrochloride is an organic molecular entity.

brand name

Coatec

OLPRINONE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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OLPRINONE HYDROCHLORIDE Suppliers

Canada 1 China 42 Europe 1 Switzerland 1 The Netherlands 1 United Kingdom 1 United States 10 Global 57
J & K SCIENTIFIC LTD.
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LETOPHARM LIMITED
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View Lastest Price from OLPRINONE HYDROCHLORIDE manufacturers

Career Henan Chemical Co
Product
OLPRINONE HYDROCHLORIDE 119615-63-3
Price
US $7.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-18

119615-63-3, OLPRINONE HYDROCHLORIDERelated Search:

Mepivacaine hydrochloride Benidipine hydrochloride Olprinone

  • Olprinone hydrochloride - Loprinone hydrochloride
  • 3-pyridinecarbonitrile,1,2-dihydro-5-(imidazo(1,2-a)pyridin-6-yl)-6-methyl-2-o
  • e1020
  • xo-,monohydrochloride,monohydrate
  • OLPRINONE HCL
  • 1,2-Dihydro-5-imidazo[1,2-α]pyridin-6-yl-6-methyl-2-oxo-3-pyridinecarbonitrile Hydrochloride
  • Coretec
  • Loprinone hydrochloride, 1,2-Dihydro-5-(imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-3-pyridinecarbonitrile hydrochloride
  • 3-Pyridinecarbonitrile,1,2-dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-,monohydrochloride
  • 119615-63-3
  • C14H10N4OHCl
  • Heterocyclic Compounds
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals