RS 102895

ChemicalBook > CAS DataBase List > RS 102895

Product Name: RS 102895
CAS No.: 300815-41-2
Chemical Name: RS 102895
Synonyms: 1'-(4-(trifluoromethyl)phenethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one;RS 102895 HYDROCHLORIDE;CC chemokine receptor,CCR,Inhibitor,RS102895,inhibit,RS-102895,RS 102895;1'-(4-(trifluoromethyl)phenethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one;1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-spiro[4h-3,1-benzoxazine-4,4'-peperidin]-2(1h)-one;Spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one, 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-;1'-(4-(TrifluoroMethyl)phenethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one hydrochloride;1'-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1H-3,1-benzoxazine-4,4'-piperidine]-2-one,hydrochloride;1'-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1H-3,1-benzoxazine-4,4'-piperidine]-2-one,hydrochloride;1'-[2-[4-(TRIFLUOROMETHYL)PHENYL]ETHYL]-SPIRO[4H-3,1-BENZOXAZINE-4,4'-PIPERIDIN]-2(1H)-ONE HYDROCHLORIDE
CBNumber: CB6504368
Molecular Formula: C21H21F3N2O2
Formula Weight: 390.4
MOL File: 300815-41-2.mol

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RS 102895 Property

Boiling point:: 446.1±45.0 °C(Predicted)
Density: 1.33±0.1 g/cm3 (20 ºC 760 Torr)
storage temp.: Desiccate at RT
solubility: DMSO: 18 mg/mL, clear, colorless
form: powder
pka: 13.46±0.20(Predicted)
color: white

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Safety

Safety Statements: 22-24/25
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: R1903
Product name: RS 102895 hydrochloride
Purity: ≥98% (HPLC), powder
Packaging: 5mg
Price: $241
Updated: 2024/03/01

Tocris

Product number: 2089
Product name: RS 102895 hydrochloride
Purity: ≥99%(HPLC)
Packaging: 10
Price: $162
Updated: 2021/12/16

Tocris

Product number: 2089
Product name: RS 102895 hydrochloride
Purity: ≥99%(HPLC)
Packaging: 50
Price: $682
Updated: 2021/12/16

Usbiological

Product number: 256510
Product name: RS 102895 hydrochloride
Packaging: 10mg
Price: $403
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0008334
Product name: RS 102895 HYDROCHLORIDE
Purity: 95.00%
Packaging: 10MG
Price: $345.45
Updated: 2021/12/16

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RS 102895 Chemical Properties,Usage,Production

Uses

RS 102895 is a CCR2-selective chemokine receptor inhibitor.

Biological Activity

CCR2-selective chemokine receptor antagonist (IC 50 values are 0.36 and 17.8 μ M for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Blocks MCP-1-stimulated calcium influx and chemotaxis with IC 50 values of 32 nM and 1.7 μ M respectively. Also inhibits α 1A , α 1D and 5-HT 1A receptors.

RS 102895 Preparation Products And Raw materials

Raw materials

Preparation Products

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RS 102895 Suppliers

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300815-41-2, RS 102895Related Search:

2,3-Dichloro-5-(trifluoromethyl)pyridine 2-fluoro-6-(trifluoroMethyl)benzene-1-sulfonyl chloride Inter-trifluoromethyl iodobenzene 4-(2-AMINOPHENYL)-1-PHENETHYLPIPERIDINE 4-(O-AMINO-PHENYL) PIPERIDINE HYDROCHLORIDE RS 102895 1-Phenethyl-4-phenyl-4-piperidinol SPIRO[4H-3,1-BENZOXAZINE-4,4'-PIPERIDIN]-2(1H)-ONE

1'-(4-(TrifluoroMethyl)phenethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one hydrochloride

1'-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1H-3,1-benzoxazine-4,4'-piperidine]-2-one,hydrochloride

RS 102895 HYDROCHLORIDE

1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-spiro[4h-3,1-benzoxazine-4,4'-peperidin]-2(1h)-one

1'-[2-[4-(TRIFLUOROMETHYL)PHENYL]ETHYL]-SPIRO[4H-3,1-BENZOXAZINE-4,4'-PIPERIDIN]-2(1H)-ONE HYDROCHLORIDE

Spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one, 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-

1'-(4-(trifluoromethyl)phenethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one

CC chemokine receptor,CCR,Inhibitor,RS102895,inhibit,RS-102895,RS 102895

1'-(4-(trifluoromethyl)phenethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one

1'-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1H-3,1-benzoxazine-4,4'-piperidine]-2-one,hydrochloride

300815-41-2

C21H21F3N2O2HCl

RS 102895 CCR2-selective chemokine receptor antagonist.

Cytokine signaling