METHYL 5-CARBOXY-N-PHENYL-2-1H-PYRIDONE

Product Name: METHYL 5-CARBOXY-N-PHENYL-2-1H-PYRIDONE
CAS No.: 77837-09-3
Chemical Name: METHYL 5-CARBOXY-N-PHENYL-2-1H-PYRIDONE
Synonyms: irfenidone 5-Carboxylate Methyl Ester;1,6-Dihydro-6-oxo-1-phenyl-nicotinic Acid Methyl Ester;Methyl 6-Oxo-1-phenyl-1,6-dihydropyridine-3-carboxylate;Methyl 1,6-dihydro-6-oxo-1-phenyl-3-pyridinecarboxylate;Methyl 1,6-dihydro-6-oxo-1-phenylpyridine-3-carboxylate;6-Oxo-1-phenyl-1,6-dihydro-pyridine-3-carboxylic acid methyl ester;3-Pyridinecarboxylicacid, 1,6-dihydro-6-oxo-1-phenyl-, methyl ester
CBNumber: CB6506766
Molecular Formula: C13H11NO3
Formula Weight: 229.23
MOL File: 77837-09-3.mol

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METHYL 5-CARBOXY-N-PHENYL-2-1H-PYRIDONE Property

Melting point:: 160-162 °C
Boiling point:: 370.0±42.0 °C(Predicted)
Density: 1.270±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: -1.40±0.63(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: M294451
Product name: Methyl5-Carboxy-N-phenyl-2-1H-pyridone
Packaging: 10mg
Price: $120
Updated: 2021/12/16

AK Scientific

Product number: 4304AJ
Product name: Methyl5-carboxy-N-phenyl-2-1H-pyridone
Packaging: 100mg
Price: $284
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 11868
Product name: Methyl5-Carboxy-N-phenyl-2-1H-pyridone
Packaging: 50mg
Price: $1720
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0014534
Product name: METHYL 5-CARBOXY-N-PHENYL-2-1H-PYRIDONE
Purity: 95.00%
Packaging: 10MG
Price: $704.55
Updated: 2021/12/16

Alichem

Product number: 77837093
Product name: Methyl6-oxo-1-phenyl-1,6-dihydropyridine-3-carboxylate
Packaging: 1g
Price: $710.7
Updated: 2021/12/16

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METHYL 5-CARBOXY-N-PHENYL-2-1H-PYRIDONE Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

A metabolite of Pirfenidone, a new drug to treat patients with kidney disease who have diabetes.

Synthesis

66171-50-4

98-80-6

77837-09-3

Methyl 6-hydroxynicotinate (6.0 g, 39.22 mmol) and phenylboronic acid (5.74 g, 47.06 mmol) were added copper(II) acetate monohydrate (11.76 g, 58.82 mmol), pyridine (6.32 mL, 78.43 mmol), and molecular sieves (4, 6.0 g) in dichloromethane (100 mL). The reaction mixture was stirred at ambient temperature for 12 h and then filtered. After standard post-extraction treatment the crude product was obtained and purified by silica gel column chromatography (100-200 mesh, eluent chloroform solution containing 1-2% methanol) to afford methyl 6-oxo-1-phenyl-1,6-dihydro-pyridine-3-carboxylate as a brown solid (5.0 g, 56% yield). The product has a melting point of 100-105°C. 1H NMR (400 MHz, CDCl3) δ 3.86 (s, 3H), 6.63 (d, J = 9.5 Hz, 1H), 7.36-7.55 (m, 5H), 7.91 (dd, J = 2.5, 9.9 Hz, 1H), 8.23 (d, J = 2.5 Hz, 1H); IR (KBr ) ν 3058, 2924, 2854, 1721, 1675, 1540, 1446, 1313, 1271, 1103 cm-1; MS 230 (M + 1).

References

[1] Patent: US2008/319026, 2008, A1. Location in patent: Page/Page column 22
[2] Patent: WO2012/122165, 2012, A2. Location in patent: Page/Page column 63

METHYL 5-CARBOXY-N-PHENYL-2-1H-PYRIDONE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYL 5-CARBOXY-N-PHENYL-2-1H-PYRIDONE Suppliers

Canada 1 China 27 Germany 1 India 2 United States 4 Global 35

J & K SCIENTIFIC LTD.

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BePharm Ltd

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Amadis Chemical Company Limited

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Aikon International Limited

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77837-09-3, METHYL 5-CARBOXY-N-PHENYL-2-1H-PYRIDONERelated Search:

5-CARBOXY-N-PHENYL-2-1H-PYRIDONE 1-O-(5-CARBOXY-N-PHENYL-2-1H-PYRIDONE)-D-GLUCURONIC ACID METHYL 5-CARBOXY-N-PHENYL-2-1H-PYRIDONE AURORA KA-3429 Methyl 1-(4-fluorophenyl)-6-oxo-1,6-dihydropyridine-3-carboxylate AURORA KA-5535

3-Pyridinecarboxylicacid, 1,6-dihydro-6-oxo-1-phenyl-, methyl ester

1,6-Dihydro-6-oxo-1-phenyl-nicotinic Acid Methyl Ester

Methyl 6-Oxo-1-phenyl-1,6-dihydropyridine-3-carboxylate

6-Oxo-1-phenyl-1,6-dihydro-pyridine-3-carboxylic acid methyl ester

irfenidone 5-Carboxylate Methyl Ester

Methyl 1,6-dihydro-6-oxo-1-phenylpyridine-3-carboxylate

Methyl 1,6-dihydro-6-oxo-1-phenyl-3-pyridinecarboxylate

77837-09-3

Aromatics Compounds

Aromatics

Metabolites

Metabolites & Impurities