BENZENE ACETIC ACID, 4-[(2-CARBOXYPHENYL)METHOXY]
- Product Name
- BENZENE ACETIC ACID, 4-[(2-CARBOXYPHENYL)METHOXY]
- CAS No.
- 55453-89-9
- Chemical Name
- BENZENE ACETIC ACID, 4-[(2-CARBOXYPHENYL)METHOXY]
- Synonyms
- Olatadine 16;2-((4-(Carboxymethyl);4-[(2-CARBOXYPHENYL)METHOXY];Acetic 2-(phenoxymethyl)benzoic anhydride;2-[(4-Carboxymethylphenoxy)methyl]benzoic acid;4-[(2-carboxyphenyl)Methoxy]benzeneacetic acid;BENZENE ACETIC ACID, 4-[(2-CARBOXYPHENYL)METHOXY];Olopatadine impurity 4/2-[[4-(Carboxymethyl)phenoxy]methyl]benzoic Acid
- CBNumber
- CB6511759
- Molecular Formula
- C16H14O5
- Formula Weight
- 286.28
- MOL File
- 55453-89-9.mol
BENZENE ACETIC ACID, 4-[(2-CARBOXYPHENYL)METHOXY] Property
- Melting point:
- 181-183 °C(Solv: ethanol (64-17-5); water (7732-18-5))
- Boiling point:
- 516.6±35.0 °C(Predicted)
- Density
- 1.337±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 3.82±0.36(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C16H14O5/c17-15(18)9-11-5-7-13(8-6-11)21-10-12-3-1-2-4-14(12)16(19)20/h1-8H,9-10H2,(H,17,18)(H,19,20)
- InChIKey
- BCYWXPITXHFIQM-UHFFFAOYSA-N
- SMILES
- C1(CC(O)=O)=CC=C(OCC2=CC=CC=C2C(O)=O)C=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 8095AB
- Product name
- 2-((4-(Carboxymethyl)phenoxy)methyl)benzoicacid
- Packaging
- 1g
- Price
- $20
- Updated
- 2021/12/16
- Product number
- FC151867
- Product name
- 2-[(4-Carboxymethylphenoxy)methyl]benzoicacid
- Packaging
- 2mg
- Price
- $59
- Updated
- 2021/12/16
- Product number
- FC151867
- Product name
- 2-[(4-Carboxymethylphenoxy)methyl]benzoicacid
- Packaging
- 5mg
- Price
- $117
- Updated
- 2021/12/16
- Product number
- FC151867
- Product name
- 2-[(4-Carboxymethylphenoxy)methyl]benzoicacid
- Packaging
- 10mg
- Price
- $203
- Updated
- 2021/12/16
- Product number
- FC151867
- Product name
- 2-[(4-Carboxymethylphenoxy)methyl]benzoicacid
- Packaging
- 25mg
- Price
- $405
- Updated
- 2021/12/16
BENZENE ACETIC ACID, 4-[(2-CARBOXYPHENYL)METHOXY] Chemical Properties,Usage,Production
Synthesis
1009378-92-0
55453-89-9
The general procedure for the synthesis of 2-[(4-carboxymethylphenoxy)methyl]benzoic acid using the compound (CAS:1009378-92-0) as starting material was as follows: intermediate I (3.2 kg, 10.2 mol) and TEBA (34 g) were dissolved in ethanol and potassium hydroxide (1.2 kg, 21.4 mol) was added with stirring. The reaction mixture was heated to reflux for 3 hours. After completion of the reaction, the ethanol was removed by evaporation. Water (20 L) was added to the residue to dissolve it, followed by acidification with concentrated hydrochloric acid to pH 1-2, when a large amount of light yellow solid precipitated. The solid was collected by filtration and the filter cake was washed with water to neutral and dried to give Intermediate II (2.42 kg) as a light yellow solid in 83.1% yield.
References
[1] Patent: CN104262318, 2016, B. Location in patent: Paragraph 0053; 0054
[2] Patent: EP2058294, 2009, A1. Location in patent: Page/Page column 8-9
[3] Patent: EP2072507, 2009, A1. Location in patent: Page/Page column 10
BENZENE ACETIC ACID, 4-[(2-CARBOXYPHENYL)METHOXY] Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from BENZENE ACETIC ACID, 4-[(2-CARBOXYPHENYL)METHOXY] manufacturers
- Product
- BENZENE ACETIC ACID, 4-[(2-CARBOXYPHENYL)METHOXY] 55453-89-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.001kg
- Purity
- 99.99%
- Supply Ability
- 2000000kg
- Release date
- 2025-06-16
- Product
- BENZENE ACETIC ACID, 4-[(2-CARBOXYPHENYL)METHOXY] 55453-89-9
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-12-11
- Product
- BENZENE ACETIC ACID, 4-[(2-CARBOXYPHENYL)METHOXY] 55453-89-9
- Price
- US $2.00/kg
- Min. Order
- 10kg
- Purity
- ask
- Supply Ability
- ask
- Release date
- 2018-12-17