ChemicalBook > CAS DataBase List > NL 1

NL 1

Product Name
NL 1
CAS No.
188532-26-5
Chemical Name
NL 1
Synonyms
NL 1;KIAA1070;NL-1, 10 mM in DMSO;5-(3,5-Di-tert-butyl-4-hydroxybenzyl)thiazolidine-2,4-dione;2,4-Thiazolidinedione, 5-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methyl]-;Inhibitor,viability,Mitochondrial Metabolism,leukemia,NL-1,CISD1,NL1,antileukemic,MitoNEET,lymphoblastic,inhibit,B-Cell,Autophagy,acute,anti-cancer,NL 1
CBNumber
CB65417106
Molecular Formula
C18H25NO3S
Formula Weight
335.46
MOL File
188532-26-5.mol
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NL 1 Property

Boiling point:
446.5±40.0 °C(Predicted)
Density 
1.167±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
DMSO: 250 mg/mL (745.25 mM)
pka
6.34±0.50(Predicted)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0110109
Product name
NL-1
Purity
99.11%
Packaging
10mg
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
BN170883
Product name
NL 1
Packaging
10mg
Price
$75
Updated
2021/12/16
ChemScene
Product number
CS-0110109
Product name
NL-1
Purity
99.11%
Packaging
50mg
Price
$260
Updated
2021/12/16
Biosynth Carbosynth
Product number
BN170883
Product name
NL 1
Packaging
50mg
Price
$262.5
Updated
2021/12/16
AK Scientific
Product number
3334CR
Product name
5-[(3,5-Ditert-butyl-4-hydroxyphenyl)methyl]-1,3-thiazolidine-2,4-dione
Packaging
50mg
Price
$404
Updated
2021/12/16
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NL 1 Chemical Properties,Usage,Production

Uses

NL-1 is a mitoNEET inhibitor with antileukemic effect. NL-1 inhibits REH and REH/Ara-C cells growth with IC50s of 47.35 μM and 56.26 μM, respectively. NL-1-mediated death in leukemic cells requires the activation of the autophagic pathway[1].

in vivo

NL-1 (10 mg/kg; intraperitoneal injection; daily; for 5 days; female NSG mice) treatment shows antileukemic activity in an in vivo mouse ALL model[1].

Animal Model:10 female NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) mice (6-8 month old) injected with TOM-1 ALL cells[1]
Dosage:10 mg/kg
Administration:Intraperitoneal injection; daily; for 5 days
Result:Showed antileukemic activity in an in vivo mouse ALL model.

References

[1] Geldenhuys WJ, et al. The MitoNEET Ligand NL-1 Mediates Antileukemic Activity in Drug-Resistant B-Cell Acute Lymphoblastic Leukemia. J Pharmacol Exp Ther. 2019 Jul;370(1):25-34. DOI:10.1124/jpet.118.255984

NL 1 Preparation Products And Raw materials

Raw materials

Preparation Products

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NL 1 Suppliers

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188532-26-5, NL 1Related Search:


  • NL 1
  • 2,4-Thiazolidinedione, 5-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methyl]-
  • 5-(3,5-Di-tert-butyl-4-hydroxybenzyl)thiazolidine-2,4-dione
  • Inhibitor,viability,Mitochondrial Metabolism,leukemia,NL-1,CISD1,NL1,antileukemic,MitoNEET,lymphoblastic,inhibit,B-Cell,Autophagy,acute,anti-cancer,NL 1
  • NL-1, 10 mM in DMSO
  • KIAA1070
  • 188532-26-5