MS023 dihydrochloride

Product Name: MS023 dihydrochloride
CAS No.: 1992047-64-9
Chemical Name: MS023 dihydrochloride
Synonyms: MS023 HCL;MS-023 2HCl;MS023 dihydrochloride;MS023 dihydrochloride, 10 mM in DMSO;N1-[4-(4-Isopropoxy-phenyl)-1H-pyrrol-3-ylmethyl]-N1-methyl-ethane-1,2-diamine dihydrochloride
CBNumber: CB65419791
Molecular Formula: C17H26ClN3O
Formula Weight: 323.87
MOL File: 1992047-64-9.mol

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MS023 dihydrochloride Property

storage temp.: Store at -20°C
solubility: DMSO: ≥ 150 mg/mL (416.30 mM)
form: Solid
color: Gray to gray purple
InChI: InChI=1S/C17H25N3O.ClH/c1-13(2)21-16-6-4-14(5-7-16)17-11-19-10-15(17)12-20(3)9-8-18;/h4-7,10-11,13,19H,8-9,12,18H2,1-3H3;1H
InChIKey: IEZPALXFXHDDHI-UHFFFAOYSA-N
SMILES: C(C1=CNC=C1C1C=CC(OC(C)C)=CC=1)N(C)CCN.Cl

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 5713
Product name: MS023dihydrochloride
Purity: ≥98%(HPLC)
Packaging: 50
Price: $1092
Updated: 2021/12/16

ChemScene

Product number: CS-0033319
Product name: MS023(dihydrochloride)
Purity: 99.49%
Packaging: 2mg
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-0033319
Product name: MS023(dihydrochloride)
Purity: 99.49%
Packaging: 5mg
Price: $100
Updated: 2021/12/16

ChemScene

Product number: CS-0033319
Product name: MS023(dihydrochloride)
Purity: 99.49%
Packaging: 10mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-0033319
Product name: MS023(dihydrochloride)
Purity: 99.49%
Packaging: 25mg
Price: $310
Updated: 2021/12/16

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MS023 dihydrochloride Chemical Properties,Usage,Production

Uses

MS023 dihydrochloride is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC50s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively[1].

in vivo

Administration of MS023 (160 mg/kg, i.p) in combination with PKC412 (100 mg/kg, i.g.) blocks MLL-r acute lymphoblastic leukemia (ALL) propagation by inhibiting maintenance of functional MLL-r ALL-initiating cells^[2].

Animal Model:	NOD-scid IL2Rgnull (NSG) mice bearing primary MLL-r ALL cells^[2]
Dosage:	160 mg/kg
Administration:	Intraperitoneal injection; PKC412 (100 mg/kg, i.g.), MS023 (160 mg/kg, i.p), or a combination for 4 weeks
Result:	Combinatorial treatment extended survival of leukemic mice relative to single treatments.

IC 50

PRMT1; PRMT3; PRMT6; PRMT8

storage

Store at -20°C

References

[1] Eram MS, et al. A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases. ACS Chem Biol. 2016 Mar 18;11(3):772-81. DOI:10.1021/acschembio.5b00839
[2] Yinghui Zhu, et al. Targeting PRMT1-mediated FLT3 methylation disrupts maintenance of MLL-rearranged acute lymphoblastic leukemia. Blood. 2019 Oct 10;134(15):1257-1268. DOI:10.1182/blood.2019002457

MS023 dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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MS023 dihydrochloride Suppliers

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1992047-64-9, MS023 dihydrochlorideRelated Search:

MS023 dihydrochloride

N1-[4-(4-Isopropoxy-phenyl)-1H-pyrrol-3-ylmethyl]-N1-methyl-ethane-1,2-diamine dihydrochloride

MS-023 2HCl

MS023 dihydrochloride, 10 mM in DMSO

MS023 HCL

1992047-64-9