YDL223C

Product Name: YDL223C
CAS No.: 489408-02-8
Chemical Name: YDL223C
Synonyms: YDL223C;HBT1, 10 mM in DMSO;HBT1 Synonyms:YDL223C;2-(2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide;1H-Pyrazole-1-acetamide, N-[3-(aminocarbonyl)-4,5,6,7-tetrahydrobenzo[b]thien-2-yl]-5-methyl-3-(trifluoromethyl)-;HBT 1,Ionotropic glutamate receptors,HBT-1,BDNF,LBD,inhibit,glutamate,AMPA,primary neurons,S518,HBT1,iGluR,AMPA-R,Inhibitor
CBNumber: CB65494048
Molecular Formula: C16H17F3N4O2S
Formula Weight: 386.39
MOL File: 489408-02-8.mol

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YDL223C Property

Boiling point:: 531.9±50.0 °C(Predicted)
Density: 1.58±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: 2mg/mL, clear
form: Solid
pka: 11.28±0.20(Predicted)
color: White to off-white
InChI: 1S/C16H17F3N4O2S/c1-8-6-11(16(17,18)19)22-23(8)7-12(24)21-15-13(14(20)25)9-4-2-3-5-10(9)26-15/h6H,2-5,7H2,1H3,(H2,20,25)(H,21,24)
InChIKey: PHLXSNIEQIKENK-UHFFFAOYSA-N
SMILES: O=C(N)C1=C(NC(CN2C(C)=CC(C(F)(F)F)=N2)=O)SC3=C1CCCC3

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Ambeed

Product number: A1465554
Product name: 2-(2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide
Purity: 98%
Packaging: 100mg
Price: $16
Updated: 2021/12/16

Ambeed

Product number: A1465554
Product name: 2-(2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide
Purity: 98%
Packaging: 250mg
Price: $23
Updated: 2021/12/16

Ambeed

Product number: A1465554
Product name: 2-(2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide
Purity: 98%
Packaging: 1g
Price: $59
Updated: 2021/12/16

Ambeed

Product number: A1465554
Product name: 2-(2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide
Purity: 98%
Packaging: 5g
Price: $202
Updated: 2021/12/16

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YDL223C Chemical Properties,Usage,Production

Description

Shmoo tip protein, substrate of Hub1p ubiquitin-like protein; mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis; HBT1 has a paralog, YNL195C, that arose from the whole genome duplication.

Uses

HBT1 is a potent α-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor (AMPA-R) potentiator. HBT1 bonds with S518 in the ligand-binding domain (LBD) of AMPA-R in a glutamate-dependent manner. HBT1 did not show remarkable bell-shaped response in brain-derived neurotrophic factor (BDNF) production in primary neurons[1].

Biochem/physiol Actions

HBT1(YDL223C) is an AMPA-R [alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor] potentiator that induces production of brain-derived neurotrophic factor (BDNF) and exhibits little agonistic effect in primary neurons. HBT1 binds to ligand-binding domain of AMPA-R in glutamate dependent manner.

References

[1] Akiyoshi Kunugi, et al. HBT1, a Novel AMPA Receptor Potentiator with Lower Agonistic Effect, Avoided Bell-Shaped Response in In Vitro BDNF Production. J Pharmacol Exp Ther. 2018 Mar;364(3):377-389. DOI:10.1124/jpet.117.245050

YDL223C Preparation Products And Raw materials

Raw materials

Preparation Products

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YDL223C Suppliers

China 55 United States 2 Global 57

Shandong Fengtai Biotechnology Co., Ltd.

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View Lastest Price from YDL223C manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: YDL223C 489408-02-8
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-06-21

Shenzhen Nexcon Pharmatechs Ltd.

Product: YDL223C 489408-02-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 2000
Release date: 2025-06-06

Shaanxi Xianhe Biotech Co., Ltd

Product: YDL223C 489408-02-8
Price: US $0.00/KG
Min. Order: 1KG
Purity: 0.99
Supply Ability: 1000KG
Release date: 2025-04-29

489408-02-8, YDL223CRelated Search:

YDL223C

1H-Pyrazole-1-acetamide, N-[3-(aminocarbonyl)-4,5,6,7-tetrahydrobenzo[b]thien-2-yl]-5-methyl-3-(trifluoromethyl)-

2-(2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide

HBT1 Synonyms:YDL223C

HBT 1,Ionotropic glutamate receptors,HBT-1,BDNF,LBD,inhibit,glutamate,AMPA,primary neurons,S518,HBT1,iGluR,AMPA-R,Inhibitor

HBT1, 10 mM in DMSO

489408-02-8

HBT1