ChemicalBook > CAS DataBase List > Pseudouridimycin (PUM)
Pseudouridimycin (PUM)
- Product Name
- Pseudouridimycin (PUM)
- CAS No.
- 1566586-52-4
- Chemical Name
- Pseudouridimycin (PUM)
- Synonyms
- Pseudouridimycin;Pseudouridimycine;Pseudouridimycin (PUM);2,4(1H,3H)-Pyrimidinedione, 5-[5-[[N-(aminoiminomethyl)glycyl-N2-hydroxy-L-glutaminyl]amino]-5-deoxy-β-D-ribofuranosyl]-
- CBNumber
- CB65540600
- Molecular Formula
- C17H26N8O9
- Formula Weight
- 486.44
- MOL File
- 1566586-52-4.mol
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Pseudouridimycin (PUM) Property
- Density
- 1.91±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 7.75±0.50(Predicted)
- color
- Light yellow to yellow
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N-Bromosuccinimide Price
Adipogen Life Sciences
- Product number
- AG-CN2-0316-M001
- Product name
- Pseudouridimycin
- Purity
- ≥85%(HPLC)
- Packaging
- 1mg
- Price
- $120
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0092613
- Product name
- Pseudouridimycin
- Packaging
- 1mg
- Price
- $270
- Updated
- 2021/12/16
Adipogen Life Sciences
- Product number
- AG-CN2-0316-M005
- Product name
- Pseudouridimycin
- Purity
- ≥85%(HPLC)
- Packaging
- 5mg
- Price
- $480
- Updated
- 2021/12/16
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Pseudouridimycin (PUM) Chemical Properties,Usage,Production
Uses
Pseudouridimycine is involved in the study of bacterial RNA polyemerase transcriptiion by trapping the open clamp state. Pseudouridimycin is an antibiotic from a new class of inhibitors that acts against Gram-positive and Gram-negative bacteria.
in vivo
Pseudouridimycin (3.2-50 mg/kg; iv; 10 min after infection and again 6 h after infection) clears infection in vivo in a mouse Streptococcus pyogenes peritonitis model (ED50 = 9 mg/kg)[3].
| Animal Model: | Female ICR mice (23-25 g) intraperitoneal injection of 0.5 mL saline solution (supplemented with 1% peptone) containing 4 × 103 cfu S. pyogenes C203[3]. |
| Dosage: | 3.2 mg/kg, 8 mg/kg, 20 mg/kg, 50 mg/kg |
| Administration: | iv; 10 min after infection and again 6 h after infection |
| Result: | Showed antibacterial activity in vivo. |
Pseudouridimycin (PUM) Preparation Products And Raw materials
Raw materials
Preparation Products
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