NDI-091143

Product Name: NDI-091143
CAS No.: 2375840-87-0
Chemical Name: NDI-091143
Synonyms: NDI-091143;NDI-091143, 10 mM in DMSO;NDI-091143;NDI091143;NDI 091143;NDI 091143,ACLY,inhibit,ATP Citrate Lyase,NDI-091143,NDI091143,Inhibitor;Methyl 3-chloro-5-(N-(4,6-difluoro-[1,1'-biphenyl]-3-yl)sulfamoyl)-4-hydroxybenzoate;Methyl 3-chloro-5-[[(4,6-difluoro[1,1'-biphenyl]-3-yl)amino]sulfonyl]-4-hydroxybenzoate;Methyl 3-chloro-5-(N-(4,6-difluoro-[1,1'-biphenyl]-3-yl)sulfamoyl)-4-hydroxybenzoate , NDI-091143;Benzoic acid, 3-chloro-5-[[(4,6-difluoro[1,1'-biphenyl]-3-yl)amino]sulfonyl]-4-hydroxy-, methyl ester
CBNumber: CB65559121
Molecular Formula: C20H14ClF2NO5S
Formula Weight: 453.84
MOL File: 2375840-87-0.mol

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NDI-091143 Property

storage temp.: -10 to -25°C
solubility: DMSO:91.0(Max Conc. mg/mL);200.5(Max Conc. mM)
form: A solid
color: White to off-white
InChI: 1S/C20H14ClF2NO5S/c1-29-20(26)12-7-14(21)19(25)18(8-12)30(27,28)24-17-9-13(15(22)10-16(17)23)11-5-3-2-4-6-11/h2-10,24-25H,1H3
InChIKey: YSTSHUWHIDBZAK-UHFFFAOYSA-N
SMILES: Fc1c(cc(c(c1)F)c3ccccc3)N[S](=O)(=O)c2c(c(cc(c2)C(=O)OC)Cl)O

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0093141
Product name: NDI-091143
Purity: 99.72%
Packaging: 5mg
Price: $70
Updated: 2021/12/16

ChemScene

Product number: CS-0093141
Product name: NDI-091143
Purity: 99.72%
Packaging: 10mg
Price: $120
Updated: 2021/12/16

ChemScene

Product number: CS-0093141
Product name: NDI-091143
Purity: 99.72%
Packaging: 25mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0093141
Product name: NDI-091143
Purity: 99.72%
Packaging: 50mg
Price: $450
Updated: 2021/12/16

ChemScene

Product number: CS-0093141
Product name: NDI-091143
Purity: 99.72%
Packaging: 100mg
Price: $750
Updated: 2021/12/16

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NDI-091143 Chemical Properties,Usage,Production

Uses

NDI-091143 is a potent and high-affinity human ATP-citrate lyase (ACLY) inhibitor with an IC50 of 2.1 nM (ADP-Glo assay), a Ki of 7.0 nM and a Kd of 2.2 nM. NDI-091143 inhibits ACLY catalysis allosterically, by stabilizing large conformational changes in the citrate domain that indirectly block the binding and recognition of citrate[1].

Biological Activity

NDI-091143 is a highly potent, allosteric ATP-citrate lyase inhibitor (human ACLY IC50 = 4.8 nM by coupled enzyme assay with 85 μM citrate; IC50 = 2.1 nM by ADP-Glo assay) th at indirectly disrupts citrate binding (Ki = 7 nM) by targeting an adjacent hydrophobic site (kon = 1.02 x 10^6/M/s, koff = 0.0019/s).

References

[1] Wei J, et al. An allosteric mechanism for potent inhibition of human ATP-citrate lyase. Nature. 2019 Apr;568(7753):566-570. DOI:10.1038/s41586-019-1094-6

NDI-091143 Preparation Products And Raw materials

Raw materials

Preparation Products

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NDI-091143 Suppliers

China 76 United States 5 Global 81

Beijing Ouhe Technology Co., Ltd

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WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

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Shanghaizehan biopharma technology co., Ltd.

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2375840-87-0, NDI-091143Related Search:

NDI-091143

NDI-091143;NDI091143;NDI 091143

Benzoic acid, 3-chloro-5-[[(4,6-difluoro[1,1'-biphenyl]-3-yl)amino]sulfonyl]-4-hydroxy-, methyl ester

NDI 091143,ACLY,inhibit,ATP Citrate Lyase,NDI-091143,NDI091143,Inhibitor

Methyl 3-chloro-5-(N-(4,6-difluoro-[1,1'-biphenyl]-3-yl)sulfamoyl)-4-hydroxybenzoate

Methyl 3-chloro-5-(N-(4,6-difluoro-[1,1'-biphenyl]-3-yl)sulfamoyl)-4-hydroxybenzoate , NDI-091143

NDI-091143, 10 mM in DMSO

Methyl 3-chloro-5-[[(4,6-difluoro[1,1'-biphenyl]-3-yl)amino]sulfonyl]-4-hydroxybenzoate

2375840-87-0

C20H14ClF2NO5S