DS-6051b

Product Name: DS-6051b
CAS No.: 1505515-69-4
Chemical Name: DS-6051b
Synonyms: AB-106;Taletrectinib;Taltinib adipate;Taretinib adipate;Taletrectinib AB-106;Taletrectinib adipate;Ropivacaine Impurity 54;Taletrectinib (DS-6051b);Taletrectinib, 10 mM in DMSO;3-(4-((R)-2-Aminopropoxy)phenyl)-N-((R)-1-(3-fluorophenyl)ethyl)imidazo[1,2-b]pyridazin-6-amine adipate
CBNumber: CB65589988
Molecular Formula: C29H34FN5O5
Formula Weight: 551.62
MOL File: 1505515-69-4.mol

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DS-6051b Property

storage temp.: Store at -20°C
solubility: DMSO : 50 mg/mL (90.64 mM; Need ultrasonic)
form: Solid
color: White to off-white
InChIKey: DORJQZDOULKINH-VAOSCPPKNA-N
SMILES: C(CC(=O)O)CCC(=O)O.N(C1C=CC2=NC=C(C3C=CC(OC[C@H](N)C)=CC=3)N2N=1)[C@@H](C1C=CC=C(F)C=1)C |&1:24,31,r|

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0120270
Product name: Taletrectinib
Purity: 99.96%
Packaging: 5mg
Price: $280
Updated: 2021/12/16

ChemScene

Product number: CS-0120270
Product name: Taletrectinib
Purity: 99.96%
Packaging: 10mg
Price: $480
Updated: 2021/12/16

ChemScene

Product number: CS-0120270
Product name: Taletrectinib
Purity: 99.96%
Packaging: 50mg
Price: $1500
Updated: 2021/12/16

ChemScene

Product number: CS-0120270
Product name: Taletrectinib
Purity: 99.96%
Packaging: 100mg
Price: $2200
Updated: 2021/12/16

DC Chemicals

Product number: DC26199
Product name: DS-6051b
Packaging: 250mg
Price: $1700
Updated: 2021/12/16

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DS-6051b Chemical Properties,Usage,Production

Uses

Taletrectinib (DS-6051b) is a potent, orally active, and next-generation selective ROS1/NTRK inhibitor. Taletrectinib potently inhibits recombinant ROS1, NTRK1, NTRK2, and NTRK3 with IC50s of 0.207, 0.622, 2.28, and 0.98 nM, respectively. Taletrectinib also inhibits ROS1 G2032R and other Crizotinib-resistant ROS1 mutants[1][2].

in vivo

Taletrectinib (DS-6051b) (25-200 mg/kg; p.o.; once daily for 18 days) shows antitumor activity^[1].
Taletrectinib (6.25-200 mg/kg; p.o.; once daily for 8 days) inhibits NTRK-rearranged cancer in Balb-c nu/nu mice bearing KM12 cells^[1].
Taletrectinib (3-100 mg/kg; p.o.; once daily for 4 days) shows rapid tumor regression in the wild-type (WT) and the G2032R-mutant Ba/F3-bearing mice without severe body weight loss^[1].

Animal Model:	Balb-c nu/nu mice (bearing U-118 MG cells)^[1]
Dosage:	25, 50, 100, and 200?mg/kg
Administration:	P.o.; once daily for 18 days
Result:	Effectively inhibited tumor growth at ≥25?mg/kg without significant body weight loss.

References

[1] Katayama R, et al. The new-generation selective ROS1/NTRK inhibitor DS-6051b overcomes crizotinib resistant ROS1-G2032R mutation in preclinical models. Nat Commun. 2019;10(1):3604. Published 2019 Aug 9. DOI:10.1038/s41467-019-11496-z
[2] Fujiwara Y, et al. Safety and pharmacokinetics of DS-6051b in Japanese patients with non-small cell lung cancer harboring ROS1 fusions: a phase I study. Oncotarget. 2018;9(34):23729-23737. Published 2018 May 4. DOI:10.18632/oncotarget.25263

DS-6051b Preparation Products And Raw materials

Raw materials

Preparation Products

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DS-6051b Suppliers

CHINA 80 India 1 United States 2 Global 83

Jinan Chuanbei Biotechnology Co., Ltd

Tel: 18654547380; 15269175648
Fax: 0531-67802093
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ChengDu TongChuangYuan Pharmaceutical Co.Ltd

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Beijing Solarbio Science & Tecnology Co., Ltd.

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View Lastest Price from DS-6051b manufacturers

HangZhou RunYan Pharma Technology Co.,LTD.

Product: AB-106;Taletrectinib 1505515-69-4
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 99% HPLC
Supply Ability: 10000
Release date: 2024-09-20

1505515-69-4, DS-6051bRelated Search:

Taletrectinib adipate

Taletrectinib

Taletrectinib (DS-6051b)

AB-106

Taletrectinib AB-106

mutations,inhibit,ROS Kinase,antitumor,AB106,Taletrectinib,glioblastoma,Inhibitor,colorectal,AB 106,cancer,NSCLC,rearrangement

3-(4-((R)-2-Aminopropoxy)phenyl)-N-((R)-1-(3-fluorophenyl)ethyl)imidazo[1,2-b]pyridazin-6-amine adipate

Taretinib adipate

Ropivacaine Impurity 54

Taletrectinib, 10 mM in DMSO

Taltinib adipate

1505515-69-4

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