VZ185

Product Name: VZ185
CAS No.: 2306193-61-1
Chemical Name: VZ185
Synonyms: VZ185;(2S,4R)-N-(2-((5-(4-(2,6-Dimethoxy-4-(2-methyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)benzyl)piperazin-1-yl)pentyl)oxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide;(2S,4R)-N-[(2-{[5-(4-{[2,6-dimethoxy-4-(2-methyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)phenyl]methyl}piperazin-1-yl)pentyl]oxy}-4-(4-methyl-1,3-thiazol-5-yl)phenyl)methyl]-1-[(2S)-2-[(1-fluorocyclopropyl)formamido]-3,3-dimethylbutanoyl]-4-hydroxypyrrolidine-2-carboxamide
CBNumber: CB65821299
Molecular Formula: C53H67FN8O8S
Formula Weight: 995.21
MOL File: 2306193-61-1.mol

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VZ185 Property

Boiling point:: 1116.1±65.0 °C(Predicted)
Density: 1.34±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 200 mg/mL (200.96 mM; Need ultrasonic)
pka: 13.79±0.20(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 6936
Product name: VZ185
Purity: ≥98%(HPLC)
Packaging: 5
Price: $259
Updated: 2021/12/16

ChemScene

Product number: CS-0082100
Product name: VZ185
Purity: >97.0%
Packaging: 1mg
Price: $393
Updated: 2021/12/16

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VZ185 Chemical Properties,Usage,Production

Biological Activity

VZ185 is a potent and selective bromodomain proteins BRD7 and BRD9 degrader th at targets BRD7/9 for von Hippel-Lindau (VHL) ubiquitin ligase complex-mediated degradation. VZ185 effectively induces cellular BRD7/9 degradation (by 90% BRD7 & 86% BRD9 in 4 h in HeLa cells, by 84% BRD7 in 2 h in RI-1 cells; BRD7/9 IC50 = 4.5/1.76 nM in 8 h in RI-1 cells) and exerts potent cytotoxicity in BRD9-dependent cancer cultures (IC50 = 3.389 nM/EOL-1 & 39.81 nM/A-204 post 7-day treatment).

storage

Store at -20°C

VZ185 Preparation Products And Raw materials

Raw materials

Preparation Products

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VZ185 Suppliers

China 20 United States 3 Global 23

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32159
Advantage: 58

Aladdin Scientific

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Email: tp@aladdinsci.com
Country: United States
ProdList: 52924
Advantage: 58

MedChemExpress

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Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

2306193-61-1, VZ185Related Search:

VZ185

(2S,4R)-N-(2-((5-(4-(2,6-Dimethoxy-4-(2-methyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)benzyl)piperazin-1-yl)pentyl)oxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide

(2S,4R)-N-[(2-{[5-(4-{[2,6-dimethoxy-4-(2-methyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)phenyl]methyl}piperazin-1-yl)pentyl]oxy}-4-(4-methyl-1,3-thiazol-5-yl)phenyl)methyl]-1-[(2S)-2-[(1-fluorocyclopropyl)formamido]-3,3-dimethylbutanoyl]-4-hydroxypyrrolidine-2-carboxamide

2306193-61-1