Raphin1 acetate
- Product Name
- Raphin1 acetate
- CAS No.
- 2242616-04-0
- Chemical Name
- Raphin1 acetate
- Synonyms
- Raphin1 acetate;Raphin1 acetate ，S0744;Raphin1 acetate, 10 mM in DMSO;(E)-2-(2,3-Dichlorobenzylidene)hydrazine-1-carboximidamide acetate;Raphin1,Phosphatase,Raphin-1 acetate,Raphin-1,Raphin1 acetate,Raphin 1,inhibit,Inhibitor
- CBNumber
- CB65821466
- Molecular Formula
- C10H12Cl2N4O2
- Formula Weight
- 291.13
- MOL File
- 2242616-04-0.mol
Raphin1 acetate Property
- storage temp.
- Store at -20°C
- solubility
- DMSO: 41.67 mg/mL (143.13 mM)
- form
- Solid
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- CS-0103214
- Product name
- Raphin1(acetate)
- Purity
- 99.22%
- Packaging
- 5mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- Axon2983
- Product name
- Raphin1acetate
- Purity
- 99%
- Packaging
- 10mg
- Price
- $121
- Updated
- 2021/12/16
- Product number
- CS-0103214
- Product name
- Raphin1(acetate)
- Purity
- 99.22%
- Packaging
- 10mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- CS-0103214
- Product name
- Raphin1(acetate)
- Purity
- 99.22%
- Packaging
- 25mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- CS-0103214
- Product name
- Raphin1(acetate)
- Purity
- 99.22%
- Packaging
- 50mg
- Price
- $435
- Updated
- 2021/12/16
Raphin1 acetate Chemical Properties,Usage,Production
Uses
Raphin1 acetate is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B). Raphin1 acetate binds strongly to the R15B-PP1c holophosphatase (Kd=33 nM), and shows ~30-fold selective in binding R15B-PP1c over R15A-PP1c. Raphin1 acetate crosses the blood-brain barrier, and reduces organismal and molecular deficits in a mouse model of a protein misfolding disease[1].
in vivo
Raphin1 acetate improves weight of HD82Q mice treated from 4 to ～10 weeks of age with 2 mg/kg of Raphin1 once a day by oral gavage. Raphin1 acetate also decreases SDS-insoluble huntingtin assemblies and nuclear inclusions in the cortex of HD82Q mice[1].
References
[1] Krzyzosiak A, et al. Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B. Cell. 2018 Aug 23;174(5):1216-1228.e19. DOI:10.1016/j.cell.2018.06.030
Raphin1 acetate Preparation Products And Raw materials
Raw materials
Preparation Products
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