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(R)-CR8 (trihydrochloride)

Product Name
(R)-CR8 (trihydrochloride)
CAS No.
1786438-30-9
Chemical Name
(R)-CR8 (trihydrochloride)
Synonyms
(R)?-?CR8 triHCl;(R)-Isomer trihydrochloride;(R)?-?CR8 (trihydrochloride);CR8, (R)-Isomer trihydrochloride;(R)-CR8 trihydrochloride, 10 mM in DMSO;(R) CR8 trihydrochloride,(R)-CR-8 trihydrochloride,(R)CR8 trihydrochloride;(R)-2-((9-Isopropyl-6-((4-(pyridin-2-yl)benzyl)amino)-9H-purin-2-yl)amino)butan-1-ol trihydrochloride
CBNumber
CB65848911
Molecular Formula
C24H30ClN7O
Formula Weight
468
MOL File
1786438-30-9.mol
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(R)-CR8 (trihydrochloride) Property

storage temp. 
Store at -20°C
solubility 
DMSO: 62.5 mg/mL (115.54 mM)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0107260
Product name
(R)-CR8trihydrochloride
Purity
99.02%
Packaging
5mg
Price
$150
Updated
2021/12/16
ChemScene
Product number
CS-0107260
Product name
(R)-CR8trihydrochloride
Purity
99.02%
Packaging
10mg
Price
$250
Updated
2021/12/16
ChemScene
Product number
CS-0107260
Product name
(R)-CR8trihydrochloride
Purity
99.02%
Packaging
50mg
Price
$1090
Updated
2021/12/16
ChemScene
Product number
CS-0107260
Product name
(R)-CR8trihydrochloride
Purity
99.02%
Packaging
100mg
Price
$1900
Updated
2021/12/16
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(R)-CR8 (trihydrochloride) Chemical Properties,Usage,Production

Uses

(R)-CR8 (CR8) trihydrochloride, a second-generation analog of Roscovitine, is a potent CDK1/2/5/7/9 inhibitor. (R)-CR8 trihydrochloride inhibits CDK1/cyclin B (IC50=0.09 μM), CDK2/cyclin A (0.072 μM), CDK2/cyclin E (0.041 μM), CDK5/p25 (0.11 μM), CDK7/cyclin H (1.1 μM), CDK9/cyclin T (0.18 μM) and CK1δ/ε (0.4 μM). (R)-CR8 trihydrochloride induces apoptosis and has neuroprotective effect[1][2]. (R)-CR8 trihydrochloride acts as a molecular glue degrader that depletes cyclin K[3].

in vivo

(R)-CR8 trihydrochloride (5mg/Kg; i.p.) results in a significant reduction in lesion size at 28 days in histological assessment[2].

Animal Model:Adult (10 to 12 weeks old) male Sprague-Dawley rats (310 to 330g)[2]
Dosage:5mg/Kg
Administration:i.p.
Result:Resulted in a significant reduction in lesion size.

IC 50

CDK1/cyclinB1: 0.09 μM (IC50); cdk2/cyclin A: 0.072 μM (IC50); CDK2/cyclinE: 0.041 μM (IC50); Cdk5/p25: 0.11 μM (IC50); CDK7/cyclin H: 1.1 μM (IC50); CDK9/Cyclin T: 0.18 μM (IC50); CK1δ/ε: 0.4 μM (IC50)

storage

Store at +4°C

References

[1] Bettayeb K, et al. CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases. Oncogene. 2008 Oct 2;27(44):5797-807. DOI:10.1038/onc.2008.191
[2] Kabadi SV, et al. CR8, a novel inhibitor of CDK, limits microglial activation, astrocytosis, neuronal loss, and neurologic dysfunction after experimental traumatic brain injury. J Cereb Blood Flow Metab. 2014 Mar;34(3):502-13. DOI:10.1038/jcbfm.2013.228
[3] Sabicki M, et al. The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K [published online ahead of print, 2020 Jun 3]. Nature. 2020;10.1038/s41586-020-2374-x. DOI:10.1038/s41586-020-2374-x

(R)-CR8 (trihydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-CR8 (trihydrochloride) Suppliers

China 32 United States 5 Global 37
BOC Sciences
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1-631-485-4226; 16314854226
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InvivoChem
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Shanghai hongqu biomedical technology co. LTD
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1786438-30-9, (R)-CR8 (trihydrochloride)Related Search:


  • (R)?-?CR8 (trihydrochloride)
  • CR8, (R)-Isomer trihydrochloride
  • (R)?-?CR8 triHCl
  • (R)-Isomer trihydrochloride
  • (R) CR8 trihydrochloride,(R)-CR-8 trihydrochloride,(R)CR8 trihydrochloride
  • (R)-2-((9-Isopropyl-6-((4-(pyridin-2-yl)benzyl)amino)-9H-purin-2-yl)amino)butan-1-ol trihydrochloride
  • (R)-CR8 trihydrochloride, 10 mM in DMSO
  • 1786438-30-9