ChemicalBook > CAS DataBase List > DOTA di(tBu)ester
DOTA di(tBu)ester
- Product Name
- DOTA di(tBu)ester
- CAS No.
- 913542-71-9
- Chemical Name
- DOTA di(tBu)ester
- Synonyms
- DOTA di(tBu)ester;Zaterol impurity 3;Gadobutrol Impurity 91;Gadobutrol Impurity 243;DOTA-bis(tert-butyl)ester;1,7-Bis(1,1-dimethylethyl) 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate;1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1,7-bis(1,1-dimethylethyl) ester;2,2'-(4,10-Bis(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetic acid;1,7-Bis(1,1-dimethylethyl) 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate or DOTA-bis(tert-butyl)ester
- CBNumber
- CB65857245
- Molecular Formula
- C24H44N4O8
- Formula Weight
- 516.63
- MOL File
- 913542-71-9.mol
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DOTA di(tBu)ester Property
- Boiling point:
- 644.7±55.0 °C(Predicted)
- Density
- 1.133±0.06 g/cm3(Predicted)
- pka
- 3.94±0.10(Predicted)
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DOTA di(tBu)ester Chemical Properties,Usage,Production
Uses
DOTA-bis(tert-butyl)ester is a DOTA-based metal chelator that can bind to radionuclides and is used to prepare radionuclide conjugates (RDCs). DOTA-bis(tert-butyl)ester can be conjugated with different salts to form different metal chelators, such as (HY-B1244) hydrochloride to obtain DOTA-MN2. DOTA-MN2 can be reacted with [67]Ga-citrate to obtain radiolabeling. When (67)Ga-DOTA-MN2 is incubated in phosphate buffer solution or mouse plasma for 24 hours, it does not undergo significant decomposition. In the biodistribution experiment of NFSa tumor mice, it has high tumor uptake and rapid plasma clearance, and is a good material for SPECT and PET studies.
IC 50
RDC Bifunctional Chelator
DOTA di(tBu)ester Preparation Products And Raw materials
Raw materials
Preparation Products
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