Boc-Val-Ala-PAB-PNP

ChemicalBook > CAS DataBase List > Boc-Val-Ala-PAB-PNP

Uses In vitro Storage

Product Name: Boc-Val-Ala-PAB-PNP
CAS No.: 1884578-00-0
Chemical Name: Boc-Val-Ala-PAB-PNP
Synonyms: Boc-Val-Ala-PAB-PNP;Boc-Val-Ala-PAB-PNP USP/EP/BP;6-Maleimidohexanoyl-valyl-alanyl-(4-aminobenzyl)-(4-nitrophenyl)-carbonate;4-[(S)-2-[(S)-2-(Boc-amino)-3-methylbutanamido]propanamido]benzyl (4-Nitrophenyl) Carbonate;L-Alaninamide, N-[(1,1-dimethylethoxy)carbonyl]-L-valyl-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-;tert-Butyl ((S)-3-methyl-1-(((S)-1-((4-((((4-nitrophenoxy)carbonyl)oxy)methyl)phenyl)amino)-1-oxopropan-2-yl)amino)-1-oxobutan-2-yl)carbamate
CBNumber: CB65864429
Molecular Formula: C27H34N4O9
Formula Weight: 558.58
MOL File: 1884578-00-0.mol

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Boc-Val-Ala-PAB-PNP Property

Boiling point:: 793.1±60.0 °C(Predicted)
Density: 1.269±0.06 g/cm3(Predicted)
form: Solid
pka: 11.26±0.46(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Iris Biotech GmbH

Product number: ADC1050
Product name: Boc-Val-Ala-PAB-PNP
Packaging: 100mg
Price: $168.75
Updated: 2021/12/16

Iris Biotech GmbH

Product number: ADC1050
Product name: Boc-Val-Ala-PAB-PNP
Packaging: 250mg
Price: $337.5
Updated: 2021/12/16

Iris Biotech GmbH

Product number: ADC1050
Product name: Boc-Val-Ala-PAB-PNP
Packaging: 1g
Price: $1012.5
Updated: 2021/12/16

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Boc-Val-Ala-PAB-PNP Chemical Properties,Usage,Production

Uses

Boc-Val-Ala-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

In vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Description

Boc-Val-Ala-PAB-PNP can be used to design cleavable ADC linkers. The Val-Ala, as shown in the ACD Zynlonta, is effectively cleaved by lysosomal proteolytic enzymes while being highly stable in human plasma. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Boc-Val-Ala-PAB-PNP Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Boc-Val-Ala-PAB-PNP manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Boc-Val-Ala-PAB-PNP 1884578-00-0
Price: US $0.00/g
Min. Order: 1g
Purity: >95.00%
Supply Ability: 1g
Release date: 2024-03-29

1884578-00-0, Boc-Val-Ala-PAB-PNPRelated Search:

Boc-Val-Ala-PAB-PNP

L-Alaninamide, N-[(1,1-dimethylethoxy)carbonyl]-L-valyl-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-

Boc-Val-Ala-PAB-PNP USP/EP/BP

4-[(S)-2-[(S)-2-(Boc-amino)-3-methylbutanamido]propanamido]benzyl (4-Nitrophenyl) Carbonate

tert-Butyl ((S)-3-methyl-1-(((S)-1-((4-((((4-nitrophenoxy)carbonyl)oxy)methyl)phenyl)amino)-1-oxopropan-2-yl)amino)-1-oxobutan-2-yl)carbamate

6-Maleimidohexanoyl-valyl-alanyl-(4-aminobenzyl)-(4-nitrophenyl)-carbonate

1884578-00-0

ADC LINKER

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