ChemicalBook > CAS DataBase List > GNE-375

GNE-375

Product Name
GNE-375
CAS No.
1926989-06-1
Chemical Name
GNE-375
Synonyms
GNE-375;GNE-375, 10 mM in DMSO;(E)-6-(But-2-en-1-yl)-4-(2,5-dimethoxy-4-(morpholine-4-carbonyl)phenyl)-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one;7H-Pyrrolo[2,3-c]pyridin-7-one, 6-(2E)-2-buten-1-yl-4-[2,5-dimethoxy-4-(4-morpholinylcarbonyl)phenyl]-1,6-dihydro-2-methyl-
CBNumber
CB65867440
Molecular Formula
C25H29N3O5
Formula Weight
451.51
MOL File
1926989-06-1.mol
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GNE-375 Property

Boiling point:
720.8±60.0 °C(Predicted)
Density 
1.246±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 50 mg/mL (110.74 mM; Need ultrasonic)
pka
16.34±0.40(Predicted)
form 
Solid
color 
Off-white to pink
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Hazard and Precautionary Statements (GHS)

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GNE-375 Chemical Properties,Usage,Production

Uses

GNE-375 is a potent and highly selective BRD9 inhibitor with an IC50 of 5 nM. GNE-375 shows >100-fold selective for BRD9 over BRD4, TAF1, and CECR2. GNE-375 decreases BRD9 binding to chromatin[1].

IC 50

BRD9: 5 nM (IC50)

References

[1] Terry D Crawford, et al. Inhibition of bromodomain-containing protein 9 for the prevention of epigenetically-defined drug resistance. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3534-3541. DOI:10.1016/j.bmcl.2017.05.063

GNE-375 Preparation Products And Raw materials

Raw materials

Preparation Products

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GNE-375 Suppliers

China 13 United States 2 Global 15
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
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58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel
86-571-88216897,88216896 13588875226
Fax
86-571-88216895
Email
sales@hzclap.com
Country
CHINA
ProdList
6312
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58
Block Chemical Technology (Shanghai) Co., Ltd.
Tel
021-20432219 13918097649
Fax
QQ79021576
Email
li_jinfei@acblock-lab.com
Country
China
ProdList
10034
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58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd
Tel
15317229551
Fax
QQ:3607245178
Email
15151849396@163.com
Country
China
ProdList
989
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58
ShangHai ChuanQian Chemcial Technique Centre
Tel
15869524721
Email
3525679403@qq.com
Country
China
ProdList
4989
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58
Block Chemical Technology (Shanghai) Co., Ltd.
Tel
021-20432219 13918097649
Fax
QQ79021576
Email
li_jinfei@acblock-lab.com
Country
China
ProdList
11318
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58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
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58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
Tel
024-024-024-88590548 18341751992
Email
757984502@qq.com
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China
ProdList
942
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58
Shanghai Yifei Biotechnology Co. , Ltd.
Tel
021-65675885 18964387627
Email
customer_service@efebio.com
Country
China
ProdList
11973
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58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
025-85560043 15850508050
Fax
025-85563444
Email
cindy.huang@synzest.com
Country
China
ProdList
12000
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1926989-06-1, GNE-375Related Search:


  • GNE-375
  • 7H-Pyrrolo[2,3-c]pyridin-7-one, 6-(2E)-2-buten-1-yl-4-[2,5-dimethoxy-4-(4-morpholinylcarbonyl)phenyl]-1,6-dihydro-2-methyl-
  • GNE-375, 10 mM in DMSO
  • (E)-6-(But-2-en-1-yl)-4-(2,5-dimethoxy-4-(morpholine-4-carbonyl)phenyl)-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one
  • 1926989-06-1