GNE-375

Product Name: GNE-375
CAS No.: 1926989-06-1
Chemical Name: GNE-375
Synonyms: GNE-375;GNE-375, 10 mM in DMSO;(E)-6-(But-2-en-1-yl)-4-(2,5-dimethoxy-4-(morpholine-4-carbonyl)phenyl)-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one;7H-Pyrrolo[2,3-c]pyridin-7-one, 6-(2E)-2-buten-1-yl-4-[2,5-dimethoxy-4-(4-morpholinylcarbonyl)phenyl]-1,6-dihydro-2-methyl-
CBNumber: CB65867440
Molecular Formula: C25H29N3O5
Formula Weight: 451.51
MOL File: 1926989-06-1.mol

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GNE-375 Property

Boiling point:: 720.8±60.0 °C(Predicted)
Density: 1.246±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 50 mg/mL (110.74 mM; Need ultrasonic)
pka: 16.34±0.40(Predicted)
form: Solid
color: Off-white to pink

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Hazard and Precautionary Statements (GHS)

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GNE-375 Chemical Properties,Usage,Production

Uses

GNE-375 is a potent and highly selective BRD9 inhibitor with an IC50 of 5 nM. GNE-375 shows >100-fold selective for BRD9 over BRD4, TAF1, and CECR2. GNE-375 decreases BRD9 binding to chromatin[1].

IC 50

BRD9: 5 nM (IC₅₀)

References

[1] Terry D Crawford, et al. Inhibition of bromodomain-containing protein 9 for the prevention of epigenetically-defined drug resistance. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3534-3541. DOI:10.1016/j.bmcl.2017.05.063

GNE-375 Preparation Products And Raw materials

Raw materials

Preparation Products

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GNE-375 Suppliers

China 13 United States 2 Global 15

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 52923
Advantage: 58

1926989-06-1, GNE-375Related Search:

GNE-375

7H-Pyrrolo[2,3-c]pyridin-7-one, 6-(2E)-2-buten-1-yl-4-[2,5-dimethoxy-4-(4-morpholinylcarbonyl)phenyl]-1,6-dihydro-2-methyl-

GNE-375, 10 mM in DMSO

(E)-6-(But-2-en-1-yl)-4-(2,5-dimethoxy-4-(morpholine-4-carbonyl)phenyl)-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one

1926989-06-1