SR12343
- Product Name
- SR12343
- CAS No.
- 2055101-86-3
- Chemical Name
- SR12343
- Synonyms
- SR12343;N-[2-(3-bromophenyl)ethyl]-2-[(5-chloro-2-pyridinyl)amino]-acetamide;Acetamide, N-[2-(3-bromophenyl)ethyl]-2-[(5-chloro-2-pyridinyl)amino]-
- CBNumber
- CB65867455
- Molecular Formula
- C15H15BrClN3O
- Formula Weight
- 368.66
- MOL File
- 2055101-86-3.mol
SR12343 Property
- Boiling point:
- 603.4±55.0 °C(Predicted)
- Density
- 1.496±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml
- form
- A crystalline solid
- pka
- 14.86±0.46(Predicted)
SR12343 Chemical Properties,Usage,Production
Biological Activity
SR 12343 is a mimetic of the IκB kinase β (IKKβ) NEMO/IKKγ-binding domain (NBD) that inhibits the protein-protein interaction between the IKK complex subunits NF-κB essential modulator (NEMO/IKKγ) and IKKβ.1 It selectively disrupts the association of NEMO/IKKγ with IKKβ over TNF receptor-associated factor 2 (TRAF2), IκBα, and IKKα in co-immunoprecipitation assays using RAW 264.7 cells at concentrations ranging from 25 to 150 μM. SR 12343 inhibits TNF-α-induced NF-κB activation in a reporter assay. It reduces increased serum IL-6 levels in a mouse model of LPS-induced endotoxemia when administered at a dose of 10 mg/kg. SR 12343 (30 mg/kg) improves grip strength and reduces muscle fibrosis in the mdx mouse model of Duchenne muscular dystrophy.
References
1.Zhao, J., Zhang, L., Mu, X., et al.Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-kB activationPLoS Biol.16(6)e2004663(2018)
SR12343 Preparation Products And Raw materials
Raw materials
Preparation Products
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