ONO7475

Product Name: ONO7475
CAS No.: 1646839-59-9
Chemical Name: ONO7475
Synonyms: ONO7475;tamnorzatinib;ONO-7475 ，S8933;ONO-7475, 10 mM in DMSO;Tamnorzatinib (ONO-7475);N-(5-((6,7-Dimethoxyquinolin-4-yl)oxy)pyridin-2-yl)-2,5-dioxo-1-phenyl-1,2,5,6,7,8-hexahydroquinoline-3-carboxamide;3-Quinolinecarboxamide, N-[5-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-pyridinyl]-1,2,5,6,7,8-hexahydro-2,5-dioxo-1-phenyl-;N-(5-((6,7-Dimethoxyquinolin-4-yl)oxy)pyridin-2-yl)-2,5-dioxo-1-phenyl-1,2,5,6,7,8-hexahydroquinoline-3-carboxamide , Tamnorzatinib;lung,tumor,leukemia,inhibit,solid,Trk Receptor,tolerant,cancer,Mer,Tropomyosin related kinase receptor,NSCLC,TAM Receptor,EGFR,ONO 7475,Tyro3,advanced,ONO7475,mutunt,Inhibitor,Axl,TKI,acute,ONO-7475,metastatic
CBNumber: CB65867703
Molecular Formula: C32H26N4O6
Formula Weight: 562.57
MOL File: 1646839-59-9.mol

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ONO7475 Property

Boiling point:: 804.0±65.0 °C(Predicted)
Density: 1.43±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
form: A crystalline solid
pka: 8.50±0.20(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0083699
Product name: ONO-7475
Purity: 99.38%
Packaging: 5mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0083699
Product name: ONO-7475
Purity: 99.38%
Packaging: 10mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0083699
Product name: ONO-7475
Purity: 99.38%
Packaging: 50mg
Price: $780
Updated: 2021/12/16

DC Chemicals

Product number: 013318
Product name: ONO-7475
Packaging: 002
Price: $950
Updated: 2021/12/16

DC Chemicals

Product number: 013318
Product name: ONO-7475
Packaging: 003
Price: $1900
Updated: 2021/12/16

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ONO7475 Chemical Properties,Usage,Production

Uses

Tamnorzatinib (ONO-7475) is a potent, selective, and orally active Axl/Mer inhibitor with IC50 values of 0.7 nM and 1.0 nM, respectively. Tamnorzatinib sensitizes AXL-overexpressing EGFR-mutant NSCLC cells to the EGFR-TKIs, suppresses the emergence and maintenance of tolerant cells. Tamnorzatinib combines with Osimertinib (HY-15772) provides a bright promise for the study of EGFR-mutated non-small cell lung cancer (NSCLC).

in vivo

Tamnorzatinib (oral gavage; 10 mg/kg or combines with 5 mg/kg Osimertinib; 29 days) treatment alone has little effect on the tumor growth. Besides, Osimertinib alone causes tumor regression within one week, but the tumors reappear within three weeks. The combined initial treatment causes tumor regression and the size of tumors is maintained for 4 weeks. No apparent adverse events, including weight loss are observed during these treatments^[1].

Animal Model:	Mouse CDX model using high-AXL-expressing PC-9KGR cells (exon 19 deletion and the exon21-T790M mutation in EGFR)^[1]
Dosage:	10 mg/kg; once daily; 19 days
Administration:	oral gavage
Result:	Had little effects alone, but combined treatments significantly decreased tumor volume without reappear.

IC 50

TrkA; Axl; Tyro3; Mer

References

[1] Okura N, et al. ONO-7475, a Novel AXL Inhibitor, Suppresses the Adaptive Resistance to Initial EGFR-TKI Treatment in?EGFR-Mutated Non-Small Lung Cancer.Clin Cancer Res.?2020 Jan 17. DOI:10.1158/1078-0432.CCR-19-2321
[2] Ruvolo PP, et al. Anexelekto/MER tyrosine kinase?inhibitor?ONO-7475?arrests growth and kills FMS-like tyrosine kinase 3-internal tandem duplication mutant acute myeloid leukemia cells by diverse mechanisms.Haematologica.?2017 Dec;102(12):2048-2057. DOI:10.3324/haematol.2017.168856

ONO7475 Preparation Products And Raw materials

Raw materials

Preparation Products

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ONO7475 Suppliers

China 45 United States 6 Global 51

Sichuan Wei Keqi Biological Technology Co., Ltd.

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TargetMol Chemicals Inc.

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1646839-59-9, ONO7475Related Search:

ONO7475

3-Quinolinecarboxamide, N-[5-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-pyridinyl]-1,2,5,6,7,8-hexahydro-2,5-dioxo-1-phenyl-

tamnorzatinib

N-(5-((6,7-Dimethoxyquinolin-4-yl)oxy)pyridin-2-yl)-2,5-dioxo-1-phenyl-1,2,5,6,7,8-hexahydroquinoline-3-carboxamide

lung,tumor,leukemia,inhibit,solid,Trk Receptor,tolerant,cancer,Mer,Tropomyosin related kinase receptor,NSCLC,TAM Receptor,EGFR,ONO 7475,Tyro3,advanced,ONO7475,mutunt,Inhibitor,Axl,TKI,acute,ONO-7475,metastatic

N-(5-((6,7-Dimethoxyquinolin-4-yl)oxy)pyridin-2-yl)-2,5-dioxo-1-phenyl-1,2,5,6,7,8-hexahydroquinoline-3-carboxamide , Tamnorzatinib

ONO-7475, 10 mM in DMSO

Tamnorzatinib (ONO-7475)

ONO-7475 ，S8933

1646839-59-9

C32H26N4O6