ChemicalBook > CAS DataBase List > N-(4-HYDROXYPHENYL)-5-METHYL-2-1H-PYRIDONE

N-(4-HYDROXYPHENYL)-5-METHYL-2-1H-PYRIDONE

Product Name
N-(4-HYDROXYPHENYL)-5-METHYL-2-1H-PYRIDONE
CAS No.
851518-71-3
Chemical Name
N-(4-HYDROXYPHENYL)-5-METHYL-2-1H-PYRIDONE
Synonyms
1-(4-Hydroxyphenyl)-5-Methylpyridin-2(1H)-one;F 351;Voxtalisib Hydrochloride;Hydronidone, 10 mM in DMSO;Pirfenidone N-(4-Hydroxyphenyl);N-(4-HYDROXYPHENYL)-5-METHYL-2-1H-PYRIDONE;1-(4-Hydroxyphenyl)-5-Methyl-2(1H)-pyridinone;2(1H)-Pyridinone, 1-(4-hydroxyphenyl)-5-methyl-;1-(4-Hydroxyphenyl)-5-methylpyridin-2(1H)-one , Hydronidone
CBNumber
CB6664017
Molecular Formula
C12H11NO2
Formula Weight
201.22
MOL File
Mol file
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N-(4-HYDROXYPHENYL)-5-METHYL-2-1H-PYRIDONE Property

Melting point:
161-162°C
Boiling point:
416.0±37.0 °C(Predicted)
Density 
1.248±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
solubility 
Chloroform (Slightly), Methanol
form 
Solid
pka
10.08±0.30(Predicted)
color 
White to Off-White
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
H949400
Product name
N-(4-Hydroxyphenyl)-5-methyl-2-1H-pyridone
Packaging
25mg
Price
$260
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
MTB0000160
Product name
N-(4-HYDROXYPHENYL)-5-METHYL-2-1H-PYRIDONE
Purity
95.00%
Packaging
5MG
Price
$756.25
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
10962
Product name
N-(4-Hydroxyphenyl)-5-methyl-2-1H-pyridone
Packaging
5mg
Price
$875
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
MTB0000160
Product name
N-(4-HYDROXYPHENYL)-5-METHYL-2-1H-PYRIDONE
Purity
95.00%
Packaging
50MG
Price
$1732.5
Updated
2021/12/16
Crysdot
Product number
CD11045992
Product name
1-(4-Hydroxyphenyl)-5-methylpyridin-2(1H)-one
Purity
95+%
Packaging
1g
Price
$772
Updated
2021/12/16
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N-(4-HYDROXYPHENYL)-5-METHYL-2-1H-PYRIDONE Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

A metabolite of Pirfenidone, a new drug to treat patients with kidney disease who have diabetes.

in vivo

Hydronidone (50-100 mg/kg; p.o.) ameliorates CCl4-induced and DDC-induced liver fibrosis and hepatic injury in mice[1].
Hydronidone significantly promotes apoptosis in activated hepatic stellate cells (aHSCs) in the CCl4- and DDC-induced liver fibrosis in mice[2].

Animal Model:Five-week-old male C57BL/6J mice (intraperitoneally injected with 10% carbon tetrachloride (CCl4) in corn oil at 5?μL/g of body weight, three times per week, for 6?weeks; or fed a diet containing 1% 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) for 4?weeks)[1]
Dosage:50, 100 mg/kg
Administration:Oral gavage (p.o.)
Result:The levels of hepatic inflammatory infiltration were improved.
Significantly reduced the collagen fibre content.
Decreased the hepatic hydroxyproline content.
Significantly reduced the mRNA levels of fibrosis-related genes, including Acta2, Col1a1, Col3a1, Mmp9 and Timp1.
Reduced the levels of α-SMA and collagen 1 (Col1) in liver tissues.
Upregulated Smad7 protein expression.

N-(4-HYDROXYPHENYL)-5-METHYL-2-1H-PYRIDONE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(4-HYDROXYPHENYL)-5-METHYL-2-1H-PYRIDONE Suppliers

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851518-71-3, N-(4-HYDROXYPHENYL)-5-METHYL-2-1H-PYRIDONERelated Search:


  • 1-(4-Hydroxyphenyl)-5-Methyl-2(1H)-pyridinone
  • F 351
  • 1-(4-Hydroxyphenyl)-5-Methylpyridin-2(1H)-one
  • Voxtalisib Hydrochloride
  • N-(4-HYDROXYPHENYL)-5-METHYL-2-1H-PYRIDONE
  • Pirfenidone N-(4-Hydroxyphenyl)
  • 2(1H)-Pyridinone, 1-(4-hydroxyphenyl)-5-methyl-
  • Hydronidone, 10 mM in DMSO
  • 1-(4-Hydroxyphenyl)-5-methylpyridin-2(1H)-one , Hydronidone
  • 851518-71-3
  • Aromatics Compounds
  • Aromatics
  • Metabolites