BVD 10
- Product Name
- BVD 10
- CAS No.
- 262418-00-8
- Chemical Name
- BVD 10
- Synonyms
- BVD 10;INPIYRLRY (MODIFICATIONS: TYR-9 = TYR-OME);L-Tyrosine, L-isoleucyl-L-asparaginyl-L-prolyl-L-isoleucyl-L-tyrosyl-L-arginyl-L-leucyl-L-arginyl-, methyl ester (9CI)
- CBNumber
- CB6668499
- Molecular Formula
- C58H92N16O13
- Formula Weight
- 1221.45
- MOL File
- 262418-00-8.mol
BVD 10 Property
- Density
- 1.39±0.1 g/cm3(Predicted)
- storage temp.
- Desiccate at -20°C
- solubility
- Soluble to 1 mg/ml in H2O
- form
- solid
- pka
- 9.75±0.15(Predicted)
- color
- White
- Water Solubility
- Soluble to 1 mg/ml in water
N-Bromosuccinimide Price
- Product number
- B5267
- Product name
- BVD10
- Packaging
- 1mg
- Price
- $313
- Updated
- 2021/12/16
- Product number
- PEP0004458
- Product name
- BVD 10
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.13
- Updated
- 2021/12/16
BVD 10 Chemical Properties,Usage,Production
Biological Activity
ki: 25.7 nm for y1neuropeptide y (npy), a 36-residue peptide amide isolated originally from porcine brain, is a member of homologous hormone family including peptide yy (pyy) and pancreatic polypeptide (pp). it is the most abundant peptide in the mammalian brain and has been shown to exhibit a wide spectrum of central and peripheral activities. these actions are mediated by at least six g-protein coupled receptor subtypes denoted as y1, y2, y3, y4, y5, and y6. bvd 10 is a highly selective and potent neuropeptide y (npy) y1 receptor antagonists.
in vitro
the inability to form such hydrogen bonding in bvd 10 may prevent or perturb the c-terminus reverse turn, which may contribute, at least in part, to the increased y1 selectivity [1]. moreover, bvd 10 and its npy analogue peptide bvd15 were characterized conformationally. the two peptides exhibit different secondary structure characteristics in trifluoroethanol. molecular modeling studies suggested that the c-terminus tyr9 is oriented in different directions in the two peptides. the difference in the structures observed may contribute to the y1 selectivity of bvd 10 relative to bvd 15 [2].
References
[1] balasubramaniam a, dhawan vc, mullins de, chance wt, sheriff s, guzzi m, prabhakaran m, parker em. highly selective and potent neuropeptide y (npy) y1 receptor antagonists based on [pro(30), tyr(32), leu(34)]npy(28-36)-nh2 (bw1911u90). j med chem. 2001 may 10;44(10):1479-82.
[2] jois sd, balasubramaniam a. conformation of neuropeptide y receptor antagonists: structural implications in receptor selectivity. peptides. 2003 jul;24(7):1035-43.
BVD 10 Preparation Products And Raw materials
Raw materials
Preparation Products
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