BOC-(+/-)-CIS-3-AMINOCYCLOHEXANE-1-CARBOXYLIC ACID
- Product Name
- BOC-(+/-)-CIS-3-AMINOCYCLOHEXANE-1-CARBOXYLIC ACID
- CAS No.
- 334932-13-7
- Chemical Name
- BOC-(+/-)-CIS-3-AMINOCYCLOHEXANE-1-CARBOXYLIC ACID
- Synonyms
- BOC-1,3-CIS-ACHC-OH;3-(BOC-AMINO)CYCLOHEXANECARBOXYLIC ACID;BOC-CIS-3-AMINOCYCLOHEXANE CARBOXYLIC ACID;BOC-CIS-1,3-AMINOCYCLOHEXANE CARBOXYLIC ACID;3-(Boc-amino)cyclohexanecarboxylic acid 97%;3-(Boc-aMino)cyclohexanecarboxylic acid, 98+%;N-BOC-cis-3-Aminocyclohexane-1-carboxylic acid;BOC-(+/-)-CIS-3-AMINOCYCLOHEXANE-1-CARBOXYLIC ACID;3-((tert-Butoxycarbonyl)aMino)cyclohexanecarboxylic acid;CIS-3-TERT-BUTOXYCARBONYLAMINOCYCLOHEXANECARBOXYLIC ACID
- CBNumber
- CB6668929
- Molecular Formula
- C12H21NO4
- Formula Weight
- 243.3
- MOL File
- 334932-13-7.mol
BOC-(+/-)-CIS-3-AMINOCYCLOHEXANE-1-CARBOXYLIC ACID Property
- Boiling point:
- 396.7±31.0 °C(Predicted)
- Density
- 1.12±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 4.77±0.13(Predicted)
- Appearance
- White to off-white Solid
- Water Solubility
- Slightly soluble in water (2.1 g/L at 25°C).
Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- WGK Germany
- 3
- HS Code
- 2924297099
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B617660
- Product name
- 3-(Boc-amino)cyclohexanecarboxylicAcid
- Packaging
- 5g
- Price
- $385
- Updated
- 2021/12/16
- Product number
- CHM0149908
- Product name
- 3-(BOC-AMINO)CYCLOHEXANECARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $664.13
- Updated
- 2021/12/16
- Product number
- 4258-1-50
- Product name
- 3-(Boc-amino)cyclohexanecarboxylic acid
- Packaging
- 10g
- Price
- $815
- Updated
- 2021/12/16
- Product number
- CHM0149908
- Product name
- 3-(BOC-AMINO)CYCLOHEXANECARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1010.63
- Updated
- 2021/12/16
- Product number
- FB59791
- Product name
- 3-(Boc-amino)cyclohexanecarboxylic acid
- Packaging
- 250mg
- Price
- $50
- Updated
- 2021/12/16
BOC-(+/-)-CIS-3-AMINOCYCLOHEXANE-1-CARBOXYLIC ACID Chemical Properties,Usage,Production
Uses
3-(Boc-amino)cyclohexanecarboxylic acid is used as pharmaceutical intermediate.
Synthesis
24424-99-5
16636-51-4
334932-13-7
Step 1: Synthesis of 3-(tert-butoxycarbonylamino)-1-cyclohexanecarboxylic acid; 1 N NaOH (41.9 mL, 105 mmol) was added to a suspension of cis-3-aminocyclohexanecarboxylic acid (10 g, 69.8 mmol) in 1,3-dioxane (100.0 mL). After stirring for 10 min, the mixture became a clarified solution followed by the addition of di-tert-butyl dicarbonate (21.08 mL, 91 mmol). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the resulting solid was collected by vacuum filtration and then dissolved in water (150 mL). The aqueous phase was acidified to pH 4 with 3 N HCl and then extracted with dichloromethane (DCM, 2 × 100 mL). The organic phases were combined and dried over anhydrous sodium sulfate (Na2SO4) and subsequently concentrated under reduced pressure to afford 3-(tert-butoxycarbonylamino)-1-cyclohexanecarboxylic acid as a white powder (17.0 g, 100% yield).
References
[1] Patent: WO2009/49157, 2009, A1. Location in patent: Page/Page column 53
[2] Patent: WO2008/75196, 2008, A1. Location in patent: Page/Page column 83
[3] Patent: WO2015/196071, A1. Location in patent: Paragraph 0634
[3] Patent: , 2015, . Location in patent: Paragraph 0634
[5] Patent: WO2017/40606, 2017, A1. Location in patent: Paragraph 0583
BOC-(+/-)-CIS-3-AMINOCYCLOHEXANE-1-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
BOC-(+/-)-CIS-3-AMINOCYCLOHEXANE-1-CARBOXYLIC ACID Suppliers
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View Lastest Price from BOC-(+/-)-CIS-3-AMINOCYCLOHEXANE-1-CARBOXYLIC ACID manufacturers
- Product
- 3-(Boc-amino)cyclohexanecarboxylic acid 334932-13-7
- Price
- US $3.00-9.00/KG
- Min. Order
- 0.1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-06-24
- Product
- BOC-(+/-)-CIS-3-AMINOCYCLOHEXANE-1-CARBOXYLIC ACID 334932-13-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2019-12-31