3-AMINO-6-(4-METHOXYPHENYL)PYRIDAZINE

Product Name: 3-AMINO-6-(4-METHOXYPHENYL)PYRIDAZINE
CAS No.: 4776-87-8
Chemical Name: 3-AMINO-6-(4-METHOXYPHENYL)PYRIDAZINE
Synonyms: 6-(4-Methoxyphenyl)-;6-(4-methoxyphenyl)pyridazin-3-amine;6-(4-Methoxyphenyl)-3-pyridazinamine;3-AMINO-6-(4-METHOXYPHENYL)PYRIDAZINE;3-Pyridazinamine, 6-(4-methoxyphenyl)-;Pyridazine, 3-amino-6-(p-methoxyphenyl)-;6 (4 Methoxyphenyl) 3 pyridazinamine,6(4Methoxyphenyl)3pyridazinamine
CBNumber: CB6669603
Molecular Formula: C11H11N3O
Formula Weight: 201.22
MOL File: 4776-87-8.mol

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3-AMINO-6-(4-METHOXYPHENYL)PYRIDAZINE Property

Melting point:: 180 °C(Solv: water (7732-18-5))
Boiling point:: 433.0±35.0 °C(Predicted)
Density: 1.201±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: DMSO, Methanol
form: crystalline solid
pka: 5.16±0.10(Predicted)
color: Light brown to brown

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Safety

Hazard Codes: Xi
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17588
Product name: 6-(4-Methoxyphenyl)-3-pyridazinamine
Purity: ≥98%
Packaging: 5mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 17588
Product name: 6-(4-Methoxyphenyl)-3-pyridazinamine
Purity: ≥98%
Packaging: 10mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 17588
Product name: 6-(4-Methoxyphenyl)-3-pyridazinamine
Purity: ≥98%
Packaging: 25mg
Price: $239
Updated: 2024/03/01

Cayman Chemical

Product number: 17588
Product name: 6-(4-Methoxyphenyl)-3-pyridazinamine
Purity: ≥98%
Packaging: 50mg
Price: $419
Updated: 2024/03/01

TRC

Product number: M266280
Product name: 6-(4-Methoxyphenyl)-3-pyridazinamine
Packaging: 250mg
Price: $925
Updated: 2021/12/16

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3-AMINO-6-(4-METHOXYPHENYL)PYRIDAZINE Chemical Properties,Usage,Production

Uses

An aminopyridazine derivative as selective GABA-A antagonist. Intermediate for the synthesis of the drug Gabazine.

Synthesis Reference(s)

Tetrahedron Letters, 42, p. 2115, 2001 DOI: 10.1016/S0040-4039(01)00134-4

Biological Activity

6-(4-methoxyphenyl)-3-pyridazinamine is a gabaa receptor antagonist.ionotropic gabaa receptors are ligand-gated ion channels that facilitate the passing of chloride ions across the cell membrane and promote an inhibitory influence on target neurons. these receptors are the major targets for benzodiazepines and related anxiolytic drugs.

in vitro

6-(4-methoxyphenyl)-3-pyridazinamine is an intermediate in the synthesis of sr 95103 [2-(3-carboxypropyl)-3-amino-4-methyl-6-phenylpyridazinium chloride]. sr 95103 was identified as a selective and competitive gaba-a receptor antagonist. moreover, sr 95103 was shown to be able to displace [3h]gaba from rat brain membranes with an apparent ki of 2.2 μm. in addition, sr 95103 was found, on the basis of biochemical, electrophysiological, and pharmacological results, to be a selective and competitive antagonist of gaba at the gaba-a receptor site [1].

in vivo

the behavioral effects of unilateral microinjections of sr 95103 into periventricular structures were studied. results showed that when injected into the medial hypothalamus (mh) or into the dorsal part of the mesencephalic central gray (cg), sr 95103 produced a dose-dependent behavioral activation together with jumps. the behavioral activation was found to be attenuated by pretreatment with thip, a gaba receptor agonist [2].

References

[1] wermuth, c. g.,bourguignon, j.j.,schlewer, g., et al. synthesis and structure-activity relationships of a series of aminopyridazine derivatives of γ-aminobutyric acid acting as selective gaba-a antagonists. journal of medicinal chemistry 30(2), 239-249 (1987).
[2] schmitt p, di scala g, brandao ml, karli p. behavioral effects of microinjections of sr 95103, a new gaba-a antagonist, into the medial hypothalamus or the mesencephalic central gray. eur j pharmacol. 1985 nov 5;117(2):149-58.

3-AMINO-6-(4-METHOXYPHENYL)PYRIDAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-AMINO-6-(4-METHOXYPHENYL)PYRIDAZINE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 6-(4-methoxyphenyl)pyridazin-3-amine 4776-87-8
Price: US $1.00-22.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100000KG
Release date: 2024-07-16

4776-87-8, 3-AMINO-6-(4-METHOXYPHENYL)PYRIDAZINERelated Search:

3-AMINO-6-(4-FLUOROPHENYL)PYRIDAZINE 6-(4-aMinophenyl)pyridazin-3-aMine 3-AMINO-6-(4-METHOXYPHENYL)PYRIDAZINE SR-95531 3-HYDRAZINO-6-(4-METHOXYPHENYL)PYRIDAZINE

Pyridazine, 3-amino-6-(p-methoxyphenyl)-

6-(4-Methoxyphenyl)-3-pyridazinamine

6-(4-methoxyphenyl)pyridazin-3-amine

6-(4-Methoxyphenyl)-

3-AMINO-6-(4-METHOXYPHENYL)PYRIDAZINE

3-Pyridazinamine, 6-(4-methoxyphenyl)-

6 (4 Methoxyphenyl) 3 pyridazinamine,6(4Methoxyphenyl)3pyridazinamine

4776-87-8

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