ChemicalBook > CAS DataBase List > [3-(4-METHOXY-PHENYL)-ISOXAZOL-5-YL]-METHANOL

[3-(4-METHOXY-PHENYL)-ISOXAZOL-5-YL]-METHANOL

Product Name: [3-(4-METHOXY-PHENYL)-ISOXAZOL-5-YL]-METHANOL
CAS No.: 206055-86-9
Chemical Name: [3-(4-METHOXY-PHENYL)-ISOXAZOL-5-YL]-METHANOL
Synonyms: (3-(4-methoxyphenyl)isoxazol-5;Methoxyphenylisoxazolylmethanol;5-Isoxazolemethanol, 3-(4-methoxyphenyl)-;[3-(4-METHOXYPHENYL)-5-ISOXAZOLYL]METHANOL;(3-(4-METHOXY PHENYL)ISOXAZOLE-5-YL)METHANOL;[3-(4-METHOXY-PHENYL)-ISOXAZOL-5-YL]-METHANOL;[3-(4-methoxyphenyl)-1,2-oxazol-5-yl]methanol;5-(Hydroxymethyl)-3-(4-methoxyphenyl)isoxazole;(3-(4-Methoxyphenyl)isoxazol-5-yl)methanol - [M89222];5-(Hydroxymethyl)-3-(4-methoxyphenyl)isoxazole, 4-[5-(Hydroxymethyl)isoxazol-3-yl]anisole
CBNumber: CB6680444
Molecular Formula: C11H11NO3
Formula Weight: 205.21
MOL File: 206055-86-9.mol

Less

[3-(4-METHOXY-PHENYL)-ISOXAZOL-5-YL]-METHANOL Property

Melting point:: 97-98°C
Boiling point:: 396.1±37.0 °C(Predicted)
Density: 1.217±0.06 g/cm3(Predicted)
storage temp.: Store at room temperature
pka: 13.32±0.10(Predicted)
form: solid
Appearance: White to off-white Solid
CAS DataBase Reference: 206055-86-9(CAS DataBase Reference)

Less

Safety

Hazard Codes: Xi,Xn
Risk Statements: 22
HazardClass: IRRITANT
HS Code: 2934999090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

TRC

Product number: M226495
Product name: [3-(4-Methoxyphenyl)isoxazol-5-yl]methanol
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Apolloscientific

Product number: OR14216
Product name: [3-(4-Methoxyphenyl)isoxazol-5-yl]methanol
Packaging: 250mg
Price: $21
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H07-1-Y2
Product name: 5-(Hydroxymethyl)-3-(4-methoxyphenyl)isoxazole
Packaging: 250mg
Price: $23
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H07-1-Y2
Product name: 5-(Hydroxymethyl)-3-(4-methoxyphenyl)isoxazole
Packaging: 1g
Price: $69
Updated: 2021/12/16

AK Scientific

Product number: W4332
Product name: [3-(4-Methoxyphenyl)isoxazol-5-yl]methanol
Packaging: 1g
Price: $197
Updated: 2021/12/16

Less

[3-(4-METHOXY-PHENYL)-ISOXAZOL-5-YL]-METHANOL Chemical Properties,Usage,Production

Synthesis

107-19-7

38435-51-7

206055-86-9

General procedure for the synthesis of [3-(4-methoxyphenyl)-5-isoxazolyl]methanol from 2-propyn-1-ol and α-chloro-4-methoxybenzaldehyde oxime: N-chlorosuccinimide (NCS) (in small amount) was slowly added to a solution of (E)-4-methoxybenzaldehyde oxime (790.0 mg, 5.3 mmol) in DMF (15.8 mL). If the reaction temperature did not increase, 1 N HCl (50.0 μL) was added to promote the reaction. Subsequently, NCS (774.2 mg, 5.8 mmol) was added. The reaction mixture was stirred at room temperature for 1 h and the progress of the reaction was monitored by TLC. Upon completion of the reaction, the reaction was quenched by the addition of ether (20.0 mL) and washed with NaCl solution (2 × 20.0 mL). The organic phase was dried with anhydrous Na2SO4 and the solvent was subsequently removed by rotary evaporation. The resulting carboxyiminocarbonyl chloride was dissolved in t-BuOH:H2O (1:1, 3.8 mL), followed by sequential addition of ethynyl alcohol (340.0 μL, 5.8 mmol), CuSO4 (7.5 mg, dissolved in 50.0 μL of water), sodium ascorbate (104.40 mg, 0.5 mmol) and NaHCO3 (1.3 g, 15.8 mmol). The reaction mixture was stirred for 4 h, after which it was diluted with ethyl acetate (20.0 mL) and washed with H2O (2 × 20.0 mL). The organic phase was dried with anhydrous Na2SO4 and the solvent was removed under reduced pressure. Purification by column chromatography [eluent: hexane:ethyl acetate, 8:2 (v/v)] afforded the target compound [3-(4-methoxyphenyl)-5-isoxazolyl]methanol (d1) as a pale yellow solid (890.0 mg, 4.3 mmol, 82% yield). Melting point: 90-92 °C. Rf value: 0.40 [Expanding agent: hexane:ethyl acetate, 60:40 (v/v)]. IR (KBr, cm-1): 3352, 2837, 1610, 1527, 1431, 1259, 1082, 840, 802. 1H NMR (400 MHz, CDCl3) δ: 7.74 (d, J = 8.5 Hz, 2H), 6.98 (d, J = 8.5 Hz, 2H), 6.52 (s, 1H), 4.81 (s, 2H), 3.86 (s, 3H).13C NMR (100 MHz, CDCl3) δ: 171.5, 162.1, 161.0, 128.2, 121.4, 114.3, 99.8, 56.7, 55.4. 55.4.

References

[1] Journal of the Iranian Chemical Society, 2014, vol. 11, # 2, p. 361 - 367
[2] Journal of the Chinese Chemical Society, 2007, vol. 54, # 3, p. 643 - 652
[3] Synthesis, 2002, # 12, p. 1663 - 1668
[4] Patent: EP2308838, 2011, A1. Location in patent: Page/Page column 79-80
[5] Letters in Organic Chemistry, 2011, vol. 8, # 4, p. 278 - 281

[3-(4-METHOXY-PHENYL)-ISOXAZOL-5-YL]-METHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

Less

[3-(4-METHOXY-PHENYL)-ISOXAZOL-5-YL]-METHANOL Suppliers

China 48 France 1 Germany 1 India 2 United Kingdom 4 United States 20 Global 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Shanghai Ennopharm Co., Ltd.

Tel: +86 (21) 6435-5022
Country: China
ProdList: 4267
Advantage: 65

Shanghai Litong Chemical Technology Co.,Ltd.

Tel: 13598610367 0373-7129549
Fax: 0373-8369699
Email: 2468833170@qq.com
Country: China
ProdList: 932
Advantage: 58

Shanghai Worldyang Chemical Co.,Ltd.

Tel: 021-021-56795766
Fax: +86-21-56795266
Email: sales@worldyachem.com
Country: China
ProdList: 9476
Advantage: 58

Shanghai YuLue Chemical Co., Ltd.

Tel: 021-60345187 13671753212
Fax: 021-34702061
Email: lzz841106@aliyun.com
Country: China
ProdList: 10263
Advantage: 55

Shanghai Na Qian Chemical Technology Co. Ltd.

Tel: 13598610367
Fax: QQ:2468833170
Email: 2841375912@qq.com
Country: China
ProdList: 2788
Advantage: 52

JW & Y Pharmlab Co., Ltd.

Tel: 021-64340559 13651849907;
Fax: 021- 64345308
Email: xinyu_shi@jwypharmlab.com.cn
Country: China
ProdList: 12000
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Shanghai Anmike Chemical Co. Ltd.

Tel: 微信 17321281695 18019252918
Fax: 021-31261685
Email: sale@amkchem.com
Country: China
ProdList: 9405
Advantage: 55

Amatek Scientific Co. Ltd.

Tel: 0512-56316828
Fax: 0512-56316826
Email: info@amateksci.com
Country: China
ProdList: 28785
Advantage: 58

Biokitchen

Tel: 021-021-021-31663258 13795219287
Fax: 021-31663258
Email: donghuanwen@126.com
Country: China
ProdList: 8816
Advantage: 58

Capot Chemical Co.,Ltd.

Tel: +86-（0）57185586718; +8613336195806
Fax: +86-571-85864795
Email: sales@capot.com
Country: China
ProdList: 29735
Advantage: 60

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: (5)02557626880
Email: dt3@aikonchem.com
Country: China
ProdList: 15493
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 400821072
Fax: 021-58955996
Email: malulu@leyan.com
Country: China
ProdList: 25000
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Shanghai Maruhua Science and Technology Co. Ltd.

Tel: 021-57171708 18721745940
Fax: QQ1139783351
Email: sales@api-chem.com
Country: China
ProdList: 1968
Advantage: 58

Hefei Molake Biotechnology Co., Ltd.

Tel: 0551-66336380 18956014586
Fax: 055166336380
Email: 983438788@qq.com
Country: China
ProdList: 2297
Advantage: 58

Nanjing Meihao Pharmaceutical Technology Co., Ltd.

Tel: meitaochem@126.com
Email: meitaochem@126.com
Country: China
ProdList: 19103
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: +86-0571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52846
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30229
Advantage: 58

Taizhou Nanfeng Pharmaceutical Research Institute

Tel: nanfengdrug@163.com; 18616377689
Email: nanfengdrug@163.com
Country: China
ProdList: 20009
Advantage: 58

Shanghai Fine Biotech Co.，Ltd

Tel: 18717800556
Email: sales@finebiotech.com
Country: China
ProdList: 2182
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 13675144456
Fax: 025-85563444
Email: sean.lv@synzest.com
Country: China
ProdList: 11438
Advantage: 58

Zhengzhou convergence chemical co., LTD

Tel: 0371-0371-55153829 18003835034
Email: 2853979819@qq.com
Country: China
ProdList: 9998
Advantage: 58

Merck KGaA

Tel: 21-20338288
Email: ordercn@merckgroup.com
Country: China
ProdList: 6394
Advantage: 58

Santa Cruz Biotechnology Inc

Tel: 021-60936350
Email: scbt@scbt.com
Country: China
ProdList: 6594
Advantage: 58

GIHI CHEMICALS CO.,LIMITED

Tel: +8618058761490
Email: info@gihichemicals.com
Country: China
ProdList: 49934
Advantage: 58

PT CHEM GROUP LIMITED

Tel: +86-85511178;
Email: peter68@ptchemgroup.com
Country: China
ProdList: 35425
Advantage: 58

Absin Bioscience Inc.

Tel: --
Fax: --
Email: chenjw@absin.cn
Country: CHINA
ProdList: 6208
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

Beijing Luyuan Bird Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 15810802415@139.com
Country: CHINA
ProdList: 6750
Advantage: 58

Xiamen Research Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1562893815@qq.com
Country: CHINA
ProdList: 6936
Advantage: 58

Shanghai Caiyou Industrial Co., Ltd.

Tel: --
Fax: --
Email: 15821073967@163.com
Country: CHINA
ProdList: 6748
Advantage: 58

Xiamen Huijia Biological Technology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6973
Advantage: 58

Shenyang longbang international Trading Co.Ltd

Tel: --
Fax: --
Email: chemexper@163.com
Country: China
ProdList: 1689
Advantage: 30

CHANGZHOU LON CHEMICAL CO.,LTD

Tel: --
Fax: --
Country: China
ProdList: 828
Advantage: 34

DSL Chemicals Co.，Ltd

Tel: --
Fax: --
Email: info@DSLChem.com
Country: China
ProdList: 6983
Advantage: 65

ChangChem Co., Ltd

Tel: --
Fax: --
Email: info@changchem.com
Country: China
ProdList: 5525
Advantage: 64

Suzhou Rovathin Foreign Trade Co.,Ltd

Tel: --
Fax: --
Email: sales@rovathin.com
Country: China
ProdList: 4395
Advantage: 58

Lanospharma Laboratories Co.,Ltd

Tel: --
Fax: --
Email: sales@lanospharma.com
Country: China
ProdList: 6329
Advantage: 56

Shanghai Fchemicals Technology Co., Ltd

Tel: --
Fax: --
Email: hqliang@fchemicals.com
Country: China
ProdList: 4375
Advantage: 47

Shanghai PI Chemicals Ltd.

Tel: --
Fax: --
Email: sales@pipharm.com
Country: China
ProdList: 6344
Advantage: 56

Shanghai ChemVia Co., Ltd

Tel: --
Fax: --
Email: chemvia@chemvia.com
Country: China
ProdList: 434
Advantage: 67

Shanghai ChemVia Co., Ltd

Tel: --
Fax: --
Email: chemvia@chemnet.com
Country: China
ProdList: 187
Advantage: 38

206055-86-9, [3-(4-METHOXY-PHENYL)-ISOXAZOL-5-YL]-METHANOLRelated Search:

[3-(4-METHOXY-PHENYL)-ISOXAZOL-5-YL]-METHANOL 3-(4-METHOXYPHENYL)-5-ISOXAZOLECARBOXYLIC ACID (3-BENZO[1,3]DIOXOL-5-YL-ISOXAZOL-5-YL)-METHANOL 3-(4-ethoxyphenyl)-1,2-oxazole-5-carboxylic acid 3-(4-METHOXY-PHENYL)-ISOXAZOLE-5-CARBOXYLIC ACID METHYL ESTER [3-(2-METHOXY-PHENYL)-ISOXAZOL-5-YL]-METHANOL [3-(3-METHOXY-PHENYL)-ISOXAZOL-5-YL]-METHANOL CBI-BB ZERO/004847 [3-(4-ETHOXYPHENYL)-5-ISOXAZOLYL]METHANOL 4-(5-[(3,4-DICHLOROPHENOXY)METHYL]-3-ISOXAZOLYL)PHENYL METHYL ETHER 3-(4-METHOXYPHENYL)-5-[(2,4,5-TRICHLOROPHENOXY)METHYL]ISOXAZOLE ETHYL 3-(4-METHOXYPHENYL)ISOXAZOLE-5-CARBOXYLATE 3-(4-METHOXYPHENYL)-5-(PHENOXYMETHYL)ISOXAZOLE CBI-BB ZERO/004875 4-(5-[(4-CHLORO-2-METHYLPHENOXY)METHYL]-3-ISOXAZOLYL)PHENYL METHYL ETHER CBI-BB ZERO/004972 CBI-BB ZERO/004971 AKOS B024786

5-(Hydroxymethyl)-3-(4-methoxyphenyl)isoxazole

5-(Hydroxymethyl)-3-(4-methoxyphenyl)isoxazole, 4-[5-(Hydroxymethyl)isoxazol-3-yl]anisole

[3-(4-METHOXYPHENYL)-5-ISOXAZOLYL]METHANOL

[3-(4-METHOXY-PHENYL)-ISOXAZOL-5-YL]-METHANOL

(3-(4-methoxyphenyl)isoxazol-5

Methoxyphenylisoxazolylmethanol

[3-(4-methoxyphenyl)-1,2-oxazol-5-yl]methanol

5-Isoxazolemethanol, 3-(4-methoxyphenyl)-

(3-(4-METHOXY PHENYL)ISOXAZOLE-5-YL)METHANOL

(3-(4-Methoxyphenyl)isoxazol-5-yl)methanol - [M89222]

206055-86-9

API intermediates

pharmacetical