ChemicalBook > CAS DataBase List > 2-(4-CHLOROPHENYL)-4-(4-FLUOROPHENYL)-5-PYRIDIN-4-YL-1,2-DIHYDROPYRAZOL-3-ONE

2-(4-CHLOROPHENYL)-4-(4-FLUOROPHENYL)-5-PYRIDIN-4-YL-1,2-DIHYDROPYRAZOL-3-ONE

Product Name
2-(4-CHLOROPHENYL)-4-(4-FLUOROPHENYL)-5-PYRIDIN-4-YL-1,2-DIHYDROPYRAZOL-3-ONE
CAS No.
219138-24-6
Chemical Name
2-(4-CHLOROPHENYL)-4-(4-FLUOROPHENYL)-5-PYRIDIN-4-YL-1,2-DIHYDROPYRAZOL-3-ONE
Synonyms
p38 MAPK Inhibitor;P38 MAP KINASE INHIBITOR;p-38 MAPK Inhibitor,p38 MAPK Inhibitor;p38 MAP Kinase Inhibitor, p38 MAPK inhibitor;2-(4-chlorophenyl)-4-(4-fluorophenyl)-5-pyridin-4-yl-1H-pyrazol-3-one;2-(4-CHLOROPHENYL)-4-(FLUOROPHENYL)-5-PYRIDIN-4-YL-1,2-DIHYDROPYRAZOL-3-ONE;2-(4-CHLOROPHENYL)-4-(4-FLUOROPHENYL)-5-PYRIDIN-4-YL-1,2-DIHYDROPYRAZOL-3-ONE;2-(4-Chlorophenyl)-4-(4-fluorophenyl)-5-(pyridin-4-yl)-1,2-dihydro-3H-pyrazol-3-one;3H-Pyrazol-3-one, 2-(4-chlorophenyl)-4-(4-fluorophenyl)-1,2-dihydro-5-(4-pyridinyl)-
CBNumber
CB6682024
Molecular Formula
C20H13ClFN3O
Formula Weight
365.79
MOL File
Mol file
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2-(4-CHLOROPHENYL)-4-(4-FLUOROPHENYL)-5-PYRIDIN-4-YL-1,2-DIHYDROPYRAZOL-3-ONE Property

Boiling point:
534.1±60.0 °C(Predicted)
Density 
1.388±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMF: 5 mg/ml; DMSO: 5 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml; Ethanol: 0.3 mg/ml
form 
A crystalline solid
pka
6.61±0.10(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17650
Product name
p38 MAPK Inhibitor
Purity
≥98%
Packaging
500μg
Price
$121
Updated
2024/03/01
Cayman Chemical
Product number
17650
Product name
p38 MAPK Inhibitor
Purity
≥98%
Packaging
1mg
Price
$230
Updated
2024/03/01
Cayman Chemical
Product number
17650
Product name
p38 MAPK Inhibitor
Purity
≥98%
Packaging
5mg
Price
$722
Updated
2024/03/01
AK Scientific
Product number
0527CA
Product name
p38MAPKinaseInhibitor
Packaging
5mg
Price
$901
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
KIN0000172
Product name
P-38 MAP KINASE INHIBITOR
Purity
95.00%
Packaging
1MG
Price
$316.05
Updated
2021/12/16
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2-(4-CHLOROPHENYL)-4-(4-FLUOROPHENYL)-5-PYRIDIN-4-YL-1,2-DIHYDROPYRAZOL-3-ONE Chemical Properties,Usage,Production

Uses

p38 MAPK-IN-4 (compound 6) is a p38 MAPK inhibitor with an 50 of 35 nM[1].

Biological Activity

Cell permeable: no', 'Product does not compete with ATP.', 'Reversible: no

IC 50

p38: 35 nM (IC50)

References

[1] S E de Laszlo, et al. Pyrroles and other heterocycles as inhibitors of p38 kinase. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2689-94. DOI:10.1016/s0960-894x(98)00495-8

2-(4-CHLOROPHENYL)-4-(4-FLUOROPHENYL)-5-PYRIDIN-4-YL-1,2-DIHYDROPYRAZOL-3-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(4-CHLOROPHENYL)-4-(4-FLUOROPHENYL)-5-PYRIDIN-4-YL-1,2-DIHYDROPYRAZOL-3-ONE Suppliers

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219138-24-6, 2-(4-CHLOROPHENYL)-4-(4-FLUOROPHENYL)-5-PYRIDIN-4-YL-1,2-DIHYDROPYRAZOL-3-ONERelated Search:

P38 Mapk Inhibitor

  • 2-(4-CHLOROPHENYL)-4-(4-FLUOROPHENYL)-5-PYRIDIN-4-YL-1,2-DIHYDROPYRAZOL-3-ONE
  • 2-(4-CHLOROPHENYL)-4-(FLUOROPHENYL)-5-PYRIDIN-4-YL-1,2-DIHYDROPYRAZOL-3-ONE
  • P38 MAP KINASE INHIBITOR
  • 2-(4-chlorophenyl)-4-(4-fluorophenyl)-5-pyridin-4-yl-1H-pyrazol-3-one
  • p38 MAPK Inhibitor
  • p-38 MAPK Inhibitor,p38 MAPK Inhibitor
  • 3H-Pyrazol-3-one, 2-(4-chlorophenyl)-4-(4-fluorophenyl)-1,2-dihydro-5-(4-pyridinyl)-
  • 2-(4-Chlorophenyl)-4-(4-fluorophenyl)-5-(pyridin-4-yl)-1,2-dihydro-3H-pyrazol-3-one
  • p38 MAP Kinase Inhibitor, p38 MAPK inhibitor
  • 219138-24-6