2-[4-(6-AMINO-2-METHYLPYRIMIDIN-4-YL)PIPERAZIN-1-YL]ETHANOL

Product Name: 2-[4-(6-AMINO-2-METHYLPYRIMIDIN-4-YL)PIPERAZIN-1-YL]ETHANOL
CAS No.: 914347-48-1
Chemical Name: 2-[4-(6-AMINO-2-METHYLPYRIMIDIN-4-YL)PIPERAZIN-1-YL]ETHANOL
Synonyms: 1-Piperazineethanol, 4-(6-amino-2-methyl-4-pyrimidinyl)-;2-[4-(6-amino-2-methyl-4-pyrimidinyl)-1-piperazinyl]ethanol;2-[4-(6-AMINO-2-METHYLPYRIMIDIN-4-YL)PIPERAZIN-1-YL]ETHANOL;2-[4-(6-aMino-2-MethylpyriMidin-4-yl)piperazin-1-yl]ethan-1-ol
CBNumber: CB6695381
Molecular Formula: C11H19N5O
Formula Weight: 237.3
MOL File: 914347-48-1.mol

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2-[4-(6-AMINO-2-METHYLPYRIMIDIN-4-YL)PIPERAZIN-1-YL]ETHANOL Property

Melting point:: 187-188 °C
Boiling point:: 465.7±45.0 °C(Predicted)
Density: 1.230
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 14.96±0.10(Predicted)

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: A614775
Product name: 2-[4-(6-Amino-2-methylpyrimidin-4-yl)piperazin-1-yl]ethanol
Packaging: 50mg
Price: $100
Updated: 2021/12/16

TRC

Product number: A614775
Product name: 2-[4-(6-Amino-2-methylpyrimidin-4-yl)piperazin-1-yl]ethanol
Packaging: 250mg
Price: $275
Updated: 2021/12/16

AK Scientific

Product number: W9397
Product name: 2-[4-(6-Amino-2-methylpyrimidin-4-yl)piperazin-1-yl]ethanol
Packaging: 250mg
Price: $118
Updated: 2021/12/16

Matrix Scientific

Product number: 072007
Product name: 2-[4-(6-Amino-2-methylpyrimidin-4-yl)piperazin-1-yl]ethanol
Purity: 95+%
Packaging: 250mg
Price: $231
Updated: 2021/12/16

Matrix Scientific

Product number: 072007
Product name: 2-[4-(6-Amino-2-methylpyrimidin-4-yl)piperazin-1-yl]ethanol
Purity: 95+%
Packaging: 1g
Price: $500
Updated: 2021/12/16

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2-[4-(6-AMINO-2-METHYLPYRIMIDIN-4-YL)PIPERAZIN-1-YL]ETHANOL Chemical Properties,Usage,Production

Synthesis

103-76-4

1749-68-4

914347-48-1

General procedure for the synthesis of 2-(4-(6-amino-2-methylpyrimidin-4-yl)piperazin-1-yl)ethanol from N-hydroxyethylpiperazine and 2-methyl-4-amino-6-chloropyrimidine: 6-chloro-2-methylpyrimidin-4-ylamine (500 mg, 3.49 mmol), N-hydroxyethylpiperazine (500 mg, 3.84 mmol) and N,N-di isopropylethylamine (DIPEA, 541 mg, 4.19 mmol) were dissolved in 1,4-dioxane (5 mL). The reaction mixture was heated to reflux for 12 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, the reaction mixture was concentrated. The residue was washed with acetonitrile (MeCN) and subsequently recrystallized from methanol (MeOH) to afford the target compound 2-[4-(6-amino-2-methylpyrimidin-4-yl)piperazin-1-yl]ethanol (220 mg, 26.5% yield) as a white solid.1H NMR (400 MHz, MeOD) data were as follows: δ 5.61 (s, 1H, ArH), δ 3.74 (t, J = 6.0 Hz, 2H, OCH2), 3.64-3.61 (m, 4H, 2×CH2), 2.67-2.62 (m, 6H, 3×CH2), 2.31 (s, 3H, ArCH3).

References

[1] Tetrahedron Letters, 2009, vol. 50, # 41, p. 5729 - 5732
[2] Patent: WO2014/52365, 2014, A1. Location in patent: Page/Page column 174-175

2-[4-(6-AMINO-2-METHYLPYRIMIDIN-4-YL)PIPERAZIN-1-YL]ETHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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2-[4-(6-AMINO-2-METHYLPYRIMIDIN-4-YL)PIPERAZIN-1-YL]ETHANOL Suppliers

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