THIOFANOX Property

Melting point:

57℃

Density 

1.1664 (rough estimate)

vapor pressure 

2.3×10^-2 Pa (25 °C)

refractive index 

1.6800 (estimate)

Flash point:

>100 °C

storage temp. 

0-6°C

Water Solubility 

5.2 g 1 l^-1 (22 °C)

pka

13.82±0.46(Predicted)

EPA Substance Registry System

Thiofanox (39196-18-4)

Safety

Hazard Codes 

T+,N

Risk Statements 

27/28-50/53

Safety Statements 

27-36/37-45-60-61

RIDADR 

2757

WGK Germany 

3

RTECS 

EL8200000

HazardClass 

6.1(a)

PackingGroup 

II

HS Code 

29309090

Hazardous Substances Data

39196-18-4(Hazardous Substances Data)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P262Do not get in eyes, on skin, or on clothing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

THIOFANOX Chemical Properties,Usage,Production

Chemical Properties

Thiofanox is a colorless solid with a pungent odor.

Uses

Thiofanox is a systemic soil insecticide used for the control of aphids, mites, thrips, plant bugs, leafhoppers and beetles in/on sugar beet and potatoes.

General Description

THIOFANOX is a colorless solid with a pungent odor. Used as a systemic insecticide and acaricide.

Air & Water Reactions

Thio and dithiocarbamates slowly decompose in aqueous solution to form carbon disulfide and methylamine or other amines. Such decompositions are accelerated by acids.

Reactivity Profile

THIOFANOX is a thiocarbamate. Flammable gases are generated by the combination of thiocarbamates and dithiocarbamates with aldehydes, nitrides, and hydrides. Thiocarbamates and dithiocarbamates are incompatible with acids, peroxides, and acid halides.

Health Hazard

THIOFANOX is a carbamate pesticide. Carbamate pesticides are moderately to highly toxic. It is a cholinesterase inhibitor.

Fire Hazard

(Non-Specific -- Carbamate Pesticide, Solid, n.o.s.) Container may explode in heat of fire. When heated to decomposition, THIOFANOX emits very toxic fumes of nitrogen and sulfur oxides. Stable at normal storage temperature; reasonably stable to hydrolysis at less than 86F at pH 5-9.

Pharmacology

The insecticidal carbamates are cholinergic. Poisoned insects and animals exhibit violent convulsions and other neuromuscular disturbances. These insecticides carbamylate acetylcholinesterase and may have a direct action on acetylcholine receptors. The mechanism of interaction with acetylcholinesterase is analogous to the normal three-step hydrolysis of acetylcholine. However, the third reaction step is much slower for the carbamylated enzyme than for the acetylated one. The importance of structural complementarity of the insecticidal carbamates to the active site of acetylcholinesterase is demonstrated by the pronounced difference in activities of D-2-(sec-butylphenyl) methylcarbamate and L-2-(sec-butylphenyl) methylcarbamate (the L isomer is five times more toxic) and of the 2-, 3-, and 4-substituted phenylmethylcarbamates, where the 4-isomers are virtually inactive.
Detoxification of carbamate insecticides occurs in vivo through microsomal hydroxylation, N-demethylation of carbamyl nitrogen, side chain oxidation, and ring hydroxylation. Methylenedioxyphenyl synergists prevent oxidation

Potential Exposure

A potential danger to those involved in the manufacture, formulation and application of this thiocarbamate systemic insecticide and acaricide.

Metabolic pathway

The hydrolytic degradation and metabolism of thiofanox in soils, plants and animals follow a common pathway. Oxidation of the S-methyl moiety is the primary reaction to yield the thiofanox sulfoxide and sulfone. Hydrolysis of the carbamate linkage to yield the oximes is only a minor pathway for thiofanox and its oxidation products (Scheme 1).

Shipping

UN2757 Carbamate pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Degradation

Thiofanox (1) is stable to hydrolysis at acidic and neutral pH levels, but readily degrades in alkaline solution (>pH 10). The major products resulted from the oxidation of the S-methyl moiety to yield thiofanox sulfoxide (2) and thiofanox sulfone (3). Hydrolysis of thiofanox and its oxidation products to the corresponding oximes (4, 5 and 6), and the further oxidation of thiofanox sulfone oxime (6) to the ketone (7) were minor reactions (Chin et al., 1976).

Incompatibilities

Thiocarbamate esters are combustible. They react violently with powerful oxidizers such as calcium hypochlorite. Poisonous gases are generated by the thermal decomposition of thiocarbamate compounds, including carbon disulfide, oxides of sulfur, oxides of nitrogen, hydrogen sulfide, ammonia, and methylamine. Many materials in this group slowly decompose in aqueous solution to form carbon disulfide and methylamine or other amines. Such decompositions are accelerated by acids. Flammable gases are generated by the combination of

Waste Disposal

In accordance with 40CFR 165 recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.